Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls

Archives of General Psychiatry

Volumn 67, Issue 10, 2010, Pages 991-1001

  Nicodemus, Kristin K ^a,b,c   Law, Amanda J ^a,c   Radulescu, Eugenia ^a   Luna, Augustin ^a   Kolachana, Bhaskar ^a   Vakkalanka, Radhakrishna ^a   Rujescu, Dan ^d   Giegling, Ina ^d   Straub, Richard E ^a   McGee, Kate ^e   Gold, Bert ^e   Dean, Michael ^e   Muglia, Pierandrea ^f   Callicott, Joseph H ^a   Tan, Hao Yang ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e NATIONAL CANCER INSTITUTE   (United States)

^f GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NEU DIFFERENTIATION FACTOR; AKT1 PROTEIN, HUMAN; DLG4 PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERBB4 PROTEIN, HUMAN; GENETIC MARKER; MEMBRANE PROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, HUMAN; NOS1AP PROTEIN, HUMAN; NRG1 PROTEIN, HUMAN; OXYGEN; PROTEIN KINASE B; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PATHOGENESIS; RISK; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; VALIDATION STUDY; WORKING MEMORY; ALGORITHM; ALLELE; ARTIFICIAL INTELLIGENCE; BLOOD; EPISTASIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE DETECTION; IMAGE PROCESSING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; REFERENCE VALUE; SHORT TERM MEMORY; STATISTICAL MODEL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALGORITHMS; ALLELES; ARTIFICIAL INTELLIGENCE; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MEMBRANE PROTEINS; MEMORY, SHORT-TERM; NEUREGULIN-1; NITRIC OXIDE SYNTHASE TYPE I; OXYGEN; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-4; REFERENCE VALUES; SCHIZOPHRENIA;

EID: 77957719415     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2010.117     Document Type: Article

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