Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population

Journal of Human Genetics

Volumn 53, Issue 10, 2008, Pages 929-935

  Shiota, Sae ^a   Tochigi, Mamoru ^a   Shimada, Hiroko ^a   Ohashi, Jun ^a   Kasai, Kiyoto ^a   Kato, Nobumasa ^a   Tokunaga, Katsushi ^a   Sasaki, Tsukasa ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chromosome 8; Epistasis; ERBB4; Neuregulin 1 (NRG1); Schizophrenia

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ERBB4 GENE; FEMALE; GENE; GENE FREQUENCY; GENE INTERACTION; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NRG1 GENE; SCHIZOPHRENIA;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SCHIZOPHRENIA;

EID: 52649146975     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-008-0332-9     Document Type: Article

References (31)

1. JA Badner ES Gershon 2002 Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia Mol Psychiatry 7 405 411
2. JC Barrett B Fry J Maller MJ Daly 2005 Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 263 265
3. I Benzel A Bansal BL Browning NW Galwey PR Maycox R McGinnis D Smart D St. Clair P Yates I Purvis 2007 Interactions among genes in the ErbB-Neuregulin signaling network are associated with increased susceptibility to schizophrenia Behav Brain Funct 3 31
4. HJ Cordell 2002 Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans Hum Mol Genet 11 2463 2468
5. G Corfas K Roy JD Buxbaum 2004 Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia Nat Neurosci 7 575 580
6. L Excoffier M Slatkin 1995 Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population Mol Biol Evol 12 921 927
7. D Fallin A Cohen L Essioux I Chumakov M Blumenfeld D Cohen NJ Schork 2001 Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease Genome Res 11 143 151
8. DL Falls 2003 Neuregulins: functions, forms, and signaling strategies Exp Cell Res 284 14 30
9. N Fukui T Muratake N Kaneko H Amagane T Someya 2006 Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population Neurosci Lett 396 117 120
10. SB Gabriel SF Schaffner H Nguyen JM Moore J Roy B Blumenstiel J Higgins M DeFelice A Lochner M Faggart SN Liu-Cordero C Rotimi A Adeyemo R Cooper R Ward ES Lander MJ Daly D Altshuler 2002 The structure of haplotype blocks in the human genome Science 296 2225 2229
11. M Gardner A Gonzalez-Neira O Lao F Calafell J Bertranpetit D Comas 2006 Extreme population differences across neuregulin 1 gene, with implications for association studies Mol Psychiatry 11 66 75
12. M Ikeda N Takahashi S Saito B Aleksic Y Watanabe A Nunokawa Y Yamanouchi T Kitajima Y Kinoshita T Kishi K Kawashima R Hashimoto H Ujike T Inada T Someya M Takeda N Ozaki N Iwata 2008 Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample Schizophr Res 101 1 8
13. N Iwata T Suzuki M Ikeda T Kitajima Y Yamanouchi T Inada N Ozaki 2004 No association with the neuregulin 1 haplotype to Japanese schizophrenia Mol Psychiatry 9 126 127
14. T Kanazawa SJ Glatt A Tsutsumi H Kikuyama J Koh H Yoneda MT Tsuang 2007 Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study Am J Med Genet B Neuropsychiatr Genet 144 113 116
15. AJ Law JE Kleinman DR Weinberger CS Weickert 2007 Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia Hum Mol Genet 16 129 141
16. CM Lewis DF Levinson LH Wise LE DeLisi RE Straub I Hovatta NM Williams SG Schwab AE Pulver SV Faraone LM Brzustowicz CA Kaufmann DL Garver HM Gurling E Lindholm H Coon HW Moises W Byerley SH Shaw A Mesen R Sherrington FA O'Neill D Walsh KS Kendler J Ekelund T Paunio J Lonnqvist L Peltonen MC O'Donovan MJ Owen DB Wildenauer W Maier G Nestadt JL Blouin SE Antonarakis BJ Mowry JM Silverman RR Crowe CR Cloninger MT Tsuang D Malaspina JM Harkavy-Friedman DM Svrakic AS Bassett J Holcomb G Kalsi A McQuillin J Brynjolfson T Sigmundsson H Petursson E Jazin T Zoega T Helgason 2003 Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia Am J Hum Genet 73 34 48
17. RC Lewontin 1964 The interaction of selection and linkage.I. General considerations; heterotic models Genetics 120 849 852
18. D Li DA Collier L He 2006 Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia Hum Mol Genet 15 1995 2002
19. MR Munafo AS Attwood J Flint 2008 Neuregulin 1 genotype and schizophrenia Schizophr Bull 34 9 12
20. KK Nicodemus A Luna R Vakkalanka T Goldberg M Egan RE Straub DR Weinberger 2006 Further evidence for association between ERBB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls Mol Psychiatry 11 1062 1069
21. N Norton V Moskvina DW Morris NJ Bray S Zammit NM Williams HJ Williams AC Preece S Dwyer JC Wilkinson G Spurlock G Kirov P Buckland JL Waddington M Gill AP Corvin MJ Owen MC O'Donovan 2006 Evidence that interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia Am J Med Genet B Neuropsychiatr Genet 141 96 101
22. TL Petryshen FA Middleton A Kirby KA Aldinger S Purcell AR Tahl CP Morley L McGann KL Gentile GN Rockwell HM Medeiros C Carvalho A Macedo A Dourado J Valente CP Ferreira NJ Patterson MH Azevedo MJ Daly CN Pato MT Pato P Sklar 2005 Support for involvement of neuregulin 1 in schizophrenia pathophysiology Mol Psychiatry 10 366 374
23. S Purcell SS Cherny PC Sham 2003 Genetic power calculator: design of linkage and association genetic mapping studies of complex traits Bioinformatics 19 149 150
24. G Silberberg A Darvasi R Pinkas-Kramarski R Navon 2006 The involvement of ERBB4 with schizophrenia: association and expression studies Am J Med Genet B Neuropsychiatr Genet 141 142 148
25. SPSS Inc. (1999) SPSS base system: syntax reference guide. Release 10.0. SPSS Inc., Chicago
26. H Stefansson E Sigurdsson V Steinthorsdottir S Bjornsdottir T Sigmundsson S Ghosh J Brynjolfsson S Gunnarsdottir O Ivarsson TT Chou O Hjaltason B Birgisdottir H Jonsson VG Gudnadottir E Gudmundsdottir A Bjornsson B Ingvarsson A Ingason S Sigfusson H Hardardottir RP Harvey D Lai M Zhou D Brunner V Mutel A Gonzalo G Lemke J Sainz G Johannesson T Andresson D Gudbjartsson A Manolescu ML Frigge ME Gurney A Kong JR Gulcher H Petursson K Stefansson 2002 Neuregulin 1 and susceptibility to schizophrenia Am J Hum Genet 71 877 892
27. H Stefansson J Sarginson A Kong P Yates V Steinthorsdottir E Gudfinnsson S Gunnarsdottir N Walker H Petursson C Crombie A Ingason JR Gulcher K Stefansson D St Clair 2003 Association of neuregulin 1 with schizophrenia confirmed in a Scottish population Am J Hum Genet 72 83 87
28. S Tosato P Dazzan D Collier 2005 Association between the neuregulin 1 gene and schizophrenia: a systemic review Schizophr Bull 31 613 617
29. N Wang JM Akey K Zhang R Chakraborty L Jin 2002 Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation Am J Hum Genet 71 1227 1234
30. Y Watanabe N Fukui A Nunokawa T Muratake N Kaneko H Kitamura T Someya 2007 No association between the ERBB3 gene and schizophrenia in a Japanese population Neurosci Res 57 574 578
31. JZ Yang TM Si Y Ruan YS Ling YH Han XL Wang M Zhou HY Zhang QM Kong C Liu DR Zhang YQ Yu SZ Liu GZ Ju L Shu DL Ma D Zhang 2003 Association study of neuregulin 1 gene with schizophrenia Mol Psychiatry 8 706 709