Linkage Disequilibrium Mapping of Schizophrenia Susceptibility to the CAPON Region of Chromosome 1q22

American Journal of Human Genetics

Volumn 74, Issue 5, 2004, Pages 1057-1063

  Brzustowicz, Linda M ^a,b,d   Simone, Jaime ^a   Mohseni, Paria ^a   Hayter, Jared E ^a   Hodgkinson, Kathleen A ^c   Chow, Eva W C ^c   Bassett, Anne S ^c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MICROSATELLITE DNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE;

ARTICLE; CAPON REGION; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 1Q; CLINICAL ARTICLE; DISEASE MARKER; FAMILIAL DISEASE; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC SUSCEPTIBILITY; HUMAN; PATHOGENESIS; PEDIGREE; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 2342625339     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/420774     Document Type: Article

References (39)

1. AbdelMalik P, Husted J, Chow EW, Bassett AS (2003) Childhood head injury and expression of schizophrenia in multiply affected families. Arch Gen Psychiatry 60:231-236
2. Abecasis GR, Cookson WO (2000) GOLD-graphical overview of linkage disequilibrium. Bioinformatics 16:182-183
3. Ahmadian A, Gharizadeh B, Gustafsson AC, Sterky F, Nyren P, Uhlen M, Lundeberg J (2000) Single-nucleotide polymorphism analysis by pyrosequencing. Anal Biochem 280:103-110
4. Bassett AS, Chow EW, O'Neill S, Brzustowicz LM (2001a) Genetic insights into the neurodevelopmental hypothesis of schizophrenia. Schizophr Bull 27:417-430
5. Bassett AS, Chow EW, Waterworth DM, Brzustowicz L (2001b) Genetic insights into schizophrenia. Can J Psychiatry 46:131-137
6. Bassett AS, Collins EJ, Nuttall SE, Honer WG (1993) Positive and negative symptoms in families with schizophrenia. Schizophr Res 11:9-19
7. Bassett AS, Honer WG (1994) Evidence for anticipation in schizophrenia. Am J Hum Genet 54:864-870
8. Bassett AS, Husted J (1997) Anticipation or ascertainment bias in schizophrenia? Penrose's familial mental illness sample. Am J Hum Genet 60:630-637
9. Boehning D, Snyder SH (2003) Novel neural modulators. Ann Rev Neurosci 26:105-131
10. Brzustowicz LM, Hayter JE, Hodgkinson KA, Chow EW, Bassett AS (2002) Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. Hum Hered 54:199-209
11. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288:678-682
12. Brzustowicz LM, Simone J, Mohseni P, Hayter JE, Chow EWC, Bassett AS (2003) Linkage disequilibrium mapping of a schizophrenia susceptibility locus on 1q22. Am J Hum Genet suppl 73:183
13. Clinton SM, Haroutunian V, Davis KL, Meador-Woodruff JH (2003) Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia. Am J Psychiatry 160:1100-1109
14. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (2000) Dexrasl: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28:183-193
15. Ferreira A, Rapoport M (2002) The synapsins: beyond the regulation of neurotransmitter release. Cell Mol Life Sci 59:589-595
16. Goring HH, Terwilliger JD (2000) Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am J Hum Genet 66:1310-1327
17. Graham TE, Prossnitz ER, Dorin RI (2002) Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. J Biol Chem 277:10876-10882
18. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D (2001) Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68:661-673
19. Harrison PJ (1999) The neuropathology of schizophrenia: a critical review of the data and their interpretation. Brain 122:593-624
20. Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361:417-419
21. Hata Y, Takai Y (1999) Roles of postsynaptic density-95/synapse-associated protein 90 and its interacting proteins in the organization of synapses. Cell Mol Life Sci 56:461-472
22. Horvath S, Xu X, Laird NM (2001) The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-306
23. Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF (2003) Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 8:445-452
24. Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH (2002a) Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc Natl Acad Sci USA 99:3199-3204
25. Jaffrey SR, Fang M, Snyder SH (2002b) Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexrasl on a single cysteine residue. Chem Biol 9:1329-1335
26. Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (1998) CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20:115-124
27. Laird NM, Horvath S, Xu X (2000) Implementing a unified approach to family-based tests of association. Genet Epidemiol 19:S36-S42
28. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, et al (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 73:34-48
29. Margolis RL, McInnis MG, Rosenblatt A, Ross CA (1999) Trinucleotide repeat expansion and neuropsychiatric disease. Arch Gen Psychiatry 56:1019-1031
30. Martin ER, Bass MP, Kaplan NL (2001) Correcting for a potential bias in the pedigree disequilibrium test. Am J Hum Genet 68:1065-1067
31. Martin ER, Monks SA, Warren LL, Kaplan NL (2000) A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet 67:146-154
32. McGuffin P, Asherson P, Owen M, Farmer A (1994) The strength of the genetic effect: is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 164:593-599
33. Ronaghi M, Uhlen M, Nyren P (1998) A sequencing method based on real-time pyrophosphate. Science 281:363, 365
34. Rosa A, Fañanás L, Cuesta MJ, Peralta V, Sham P (2002) 1q21-q22 locus is associated with susceptibility to the reality-distortion syndrome of schizophrenia spectrum disorders. Am J Med Genet 114:516-518
35. Sawa A, Snyder SH (2003) Schizophrenia: neural mechanisms for novel therapies. Mol Med 9:3-9
36. Shaw SH, Kelly M, Smith AB, Shields G, Hopkins PJ, Loftus J, Laval SH, Vita A, De Hert M, Cardon LR, Crow TJ, Sherrington R, DeLisi LE (1998) A genomewide search for schizophrenia susceptibility genes. Am J Med Genet 81:364-376
37. Sobel E, Lange K (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 58:1323-1337
38. Sobel E, Sengul H, Weeks DE (2001) Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum Hered 52:121-131
39. Zornberg GL, Buka SL, Tsuang MT (2000) Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study. Am J Psychiatry 157:196-202