Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 141 B, Issue 3, 2006, Pages 281-286

  Kim, Jong Won ^a   Lee, Yu Sang ^b   Cho, Eun Young ^a   Jang, Yong Lee ^c   Park, Dong Yeon ^a   Choi, Kyeong Sook ^a   Jeun, Hyun Ok ^a   Cho, Seung Hee ^a   Jang, Sue Yon ^a   Hong, Kyung Sue ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Yongin Mental Hospital   (South Korea)

^c Chuncheon National Hospital   (South Korea)

Author keywords

Association; Chromosome 8p12; Linkage; Neuregulin 1; Schizophrenia

Indexed keywords

NEU DIFFERENTIATION FACTOR;

ADULT; ARTICLE; AUDITORY HALLUCINATION; CHROMOSOME 8P; CONTROLLED STUDY; FEMALE; GENE; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; NRG1 GENE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; KOREA; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MALE; MICROSATELLITE REPEATS; NERVE TISSUE PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; VARIATION (GENETICS);

EID: 33645971936     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30209     Document Type: Article

References (26)

1. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Press.
2. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SE, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis SE, Pulver AE. 1998. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20(1):70-73.
3. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS, 1999. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 65(4):1096-1103.
4. Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M. 1998. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry 55(1):67-74.
5. Cardno AG, Gottesman II. 2000. Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 97(1):12-17.
6. Corfas G, Roy K, Buxbaum JD. 2004. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci 7(6):575-580.
7. Corvin AP, Morris DW, McGhee K, Schwaiger S, Scully P, Quinn J, Meagher D, St. Glair D, Waddington JL, Gill M. 2004. Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the neuregulin-1 locus. Mol Psychiatry 9(2):208-213.
8. Falls DL. 2003. Neuregulins: Functions, forms, and signaling strategies. Exp Cell Res 284(1):14-30.
9. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D. 2001. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes Hq23.3-24 and 20q12.1-11.23. Am J Hum Genet 68(3):661-673.
10. Iwata N, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Ozaki N, 2004. No association with the neuregulin 1 haplotype to Japanese schizophrenia. Mol Psychiatry 9(2):126-127.
11. Joo EJ, Joo YH, Hong JP, Hwang S, Maeng SJ, Han JH, Yang BH, Lee YS, Kim YS. 2004. Korean version of the diagnostic interview for genetic studies: Validity and reliability. Compr Psychiatry 45(3):225-229.
12. Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, Meyer J, Zambuto CT, Schmitt K, Matise TC, Friedman JMH, Hampe C, Lee H, Shore D, Wynne D, Faraone SV, Tsuang MT, Cloninger CR. 1998. NIMH Genetics Initiative Millenium Schizophrenia Consortium: Linkage analysis of African-American pedigrees. Am J Med Genet 81(4):282-289.
13. Kendler KS, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE. 1996. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia families. Am J Psychiatry 153(12):1534-1540.
14. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58(6):1347-1363.
15. Levinson DF, Wildenauer DB, Schwab SG, Albus M, Hallmayer J, Lerer B, Maier W, Blackwood D, Muir W, St. Glair D, Morris S, Moises HW, Yang L, Kristbjarnarson H, Helgason T, Wiese C, Collier DA, Holmans P, Daniels J, Rees M, Asherson P, Roberts Q, Cardno A, Arranz MJ, Vallada H, Ball D, Kunugi H, Murray RM, Powell JF, Nanko S, Sham P, Gill M, McGuffin P, Owen MJ, Pulver AE, Antonarakis SE, Babb R, Blouin J-L, DeMarchi N, Dombroski B, Housman D, Karayiorgou M, Ott J, Kasch L, Kazazian H, Lasseter VK, Loetscher E, Luebbert H, Nestadt G, Ton C, Wolyniec PS, Laurent C, deChaldee M, Thibaut F, Jay M, Samolyk D, Petit M, Campion D, Mallet J, Straub RE, MacLean CJ, Easter SM, O'Neill FA, Walsh D, Kendler KS, Gejman PV, Cao Q, Gershon E, Badner J, Beshah E, Zhang J, Riley BP, Rajagopalan S, Mogudi-Carter M, Jenkins T, Williamson R, DeLisi LE, Garner C, Kelly M, LeDuc C, Cardon L, Lichter J, Harris T, Loftus J, Shields G, Comasi M, Vita A, Smith A, Dann J, Oslyn G, Gurling H, Kalsi G, Brynjolfsson J, Curtis D, Sigmundsson T, Butler R, Read T, Murphy P, Chen AC, Petursson H, Byerley B, Hoff M, Holik J, Coon H, Levinson DF, N1ancarrow DJ, Crowe RR, Andreasen N, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Walters MK, Lennon DP, Hayward NK, Sandkuijl LA, Mowry BJ, Aschauer HN, Meszaros K, Lenzinger E, Fuchs K, Yang L, Heiden AM, Moises HW, Kruglyak L, Daly MJ, Matise TC. 1996. Additional support for schizophrenia linkage on chromosome 6 and 8: A multicenter study. Am J Med Genet 67:580-594.
16. Li T, Stefansson H, Gudfinnsson E, Cai G, Liu X, Murray RM, Steinthorsdottir V, Januel D, Gudnadottir VG, Petursson H, Ingason A, Gulcher JR, Stefansson K, Collier DA. 2004. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Mol Psychiatry 9(7):698-704.
17. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, Kimberland M, Babb R, Vourlis S, Chen Laioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonarakis SE, Housman D, Kazazian HH. 1995. Schizophrenia: A genome scan targets chromosomes 3p and Sp as potential sites of susceptibility genes. Am J Med Genet 60(3):252-260.
18. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6, and 8. 1996. Additional support for schizophrenia linkage on chromosomes 6 and 8: Amulticenter study. Am J Med Genet 67:580-594.
19. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. 2002. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71(4):877-892.
20. Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E, Gunnarsdottir S, Walker N, Petursson H, Crombie C, Ingason A, Gulcher JR, Stefansson K, St. Clair D. 2003. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 72(1):83-87.
21. Stefansson H, Steinthorsdottir V, Thorgeirsson TE, Gulcher JR, Stefansson K. 2004. Neuregulin 1 and schizophrenia. Ann Med 36(1):62-71.
22. Tang JX, Chen WY, He G, Zhou J, Gu NF, Feng GY, He L. 2004. Polymorphisms within 5′ end of the neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. Mol Psychiatry 9(1):11-12.
23. Thiselton DL, Webb BT, Neale BM, Ribble RC, O'Neill FA, Walsh D, Riley BP, Kendler KS. 2004. No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). Mol Psychiatry 9(8):777-783; image 729.
24. Williams NM, Preece A, Spurlock G, Norton N, Williams HJ, Zammit S, O'Donovan MC, Owen MJ. 2003. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol Psychiatry 8(5):485-487.
25. Yang JZ, Si TM, Ruan Y, Ling YS, Han YH, Wang XL, Zhou M, Zhang HY, Kong QM, Liu C, Zhang DR, Yu YQ, Liu SZ, Ju GZ, Shu L, Ma DL, Zhang D. 2003. Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry 8(7):706-709.
26. Zhao X, Shi Y, Tang J, Tang R, Yu L, Gu N, Feng G, Zhu S, Liu H, Xing Y, Zhao S, Sang H, Guan Y, St. Clair D, He L. 2004. A case control and family based association study of the neuregulin1 gene and schizophrenia. J Med Genet 41(1):31-34.