A unified statistical approach for determining significant signals in images of cerebral activation

Human Brain Mapping

Volumn 4, Issue 1, 1996, Pages 58-73

  Worsley, K J ^a   Marrett, S ^b   Neelin, P ^b   Vandal, A C ^a   Friston, K J ^c   Evans, A C ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c WELLCOME TRUST CENTRE FOR NEUROIMAGING   (United Kingdom)

Author keywords

Euler characteristic; fMRI; PET; random fields

Indexed keywords

ARTICLE; BRAIN; FUNCTIONAL ASSESSMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL MODEL; THEORY;

EID: 0029931242     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O     Document Type: Article

References (19)

1. Adler RJ (1981). The Geometry of Random Fields. New York: Wiley.
2. Evans AC, Marrett S, Torrescorzo J, Ku S, Collins L (1991): MRI-PET correlative analysis using a volume of interest (VOI) atlas. J Cereb Blood Flow Metab 11(2):A69-A78.
3. Evans AC, Marrett S, Neelin P, Collins L, Worsley KJ, Dai W, Milot S, Meyer E, Bub D (1992): Anatomical mapping of functional activation in stereotactic coordinate space. Neurolmage 1:43-53.
4. Fox PT, Perlmutter JS, Raichle ME (1985): A stereotactic method of anatomical localization for positron emission tomography. J Comput Assisted Tomogr 9(1):141-153.
5. Fox FT, Mintun MA, Reiman EM, Raichle ME (1988): Enhanced detection of focal brain responses using intersubject averaging and distribution analysis of subtracted PET images. J Cereb Blood Flow Metab 8:642-653.
6. Friston KJ, Frith CD, Liddle PF, Lammertsma AA, Dolan RD, Frackowiak RSJ (1990): The relationship between local and global changes in PET scans. J Cereb Blood Flow Metab 10:458-466.
7. Friston KJ, Frith CD, Liddle PF, Frackowiak RSJ (1991): Comparing functional (PET) images: The assessment of significant change. J Cereb Blood Flow Metab 11:690-699.
8. Friston KJ, Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans AC (1994). Assessing the significance of focal activations using their spatial extent. Hum Brain Mapping 1:214-220.
9. Friston KJ, Holmes AP, Worsley KJ, Poline J-B, Frith CD, Frackowiak RSJ (1995a): Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapping 2:189-210.
10. Friston KJ, Holmes AP, Poline J-B, Grasby BJ, Williams CR, Frackowiak RSJ, Turner R (1995b): Analysis of fMRI time-series revisited. Neurolmage 2:45-53.
11. Santaló LA (1976): Integral geometry and geometric probability. In: Rota G-C (ed): Encyclopedia of Mathematics and its Applications, Volume 1. Reading, Massachusetts: Addison-Wesley.
12. Siegmund DO, Worsley KJ (1995): Testing for a signal with unknown location and scale in a stationary Gaussian random field. Ann Statistics 23:608-639.
13. 2, F and t fields. Adv Appl Probability 26:13-42.
14. Worsley KJ (1995a): Estimating the number of peaks in a random field using the Hadwiger characteristic of excursion sets with applications to medical images. Ann Statistics 23:640-669.
15. Worsley KJ (1995b): Boundary corrections for the expected Euler characteristic of excursion sets of random fields, with an application to astrophysics. Adv Appl Probability 27:943-959.
16. Worsley KJ (1996): The geometry of random images. Chance 9(1):27-40.
17. Worsley KJ, Friston KJ (1995) : Analysis of fMRI time-series revisited-again. Neurolmage 2:173-181.
18. Worsley KJ, Evans AC, Marrett S, Neelin P (1992): A three dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 12:900-918.
19. Worsley KJ, Evans AC, Marrett S, Neelin P (1993): Detecting and estimating the regions of activation in CBF activation studies in human brain. In: Uemura K, Lassen NA, Jones T, Kanno I (eds): Quantification of Brain Function: Tracer kinetics and image analysis in brain PET. Tokyo: Excerpta Medica, pp 535-548.