메뉴 건너뛰기




Volumn 15, Issue 19-20, 2010, Pages 812-815

When pharmaceutical companies publish large datasets: An abundance of riches or fool's gold?

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

EID: 77957676467     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.08.010     Document Type: Short Survey
Times cited : (36)

References (40)
  • 1
    • 71749108117 scopus 로고    scopus 로고
    • Competitive collaboration in the pharmaceutical and biotechnology industry
    • Bingham A., Ekins S. Competitive collaboration in the pharmaceutical and biotechnology industry. Drug Discov. Today 2009, 14:1079-1081.
    • (2009) Drug Discov. Today , vol.14 , pp. 1079-1081
    • Bingham, A.1    Ekins, S.2
  • 2
    • 43049159565 scopus 로고    scopus 로고
    • The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients
    • Hunter A.J. The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients. Drug Discov. Today 2008, 13:371-373.
    • (2008) Drug Discov. Today , vol.13 , pp. 371-373
    • Hunter, A.J.1
  • 3
    • 70049099472 scopus 로고    scopus 로고
    • Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery
    • Barnes M.R., et al. Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat. Rev. Drug Discov. 2009, 8:701-708.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 701-708
    • Barnes, M.R.1
  • 4
    • 52049085009 scopus 로고    scopus 로고
    • Drug discovery in the era of Facebook - new tools for scientific networking
    • Bailey D.S., Zanders E.D. Drug discovery in the era of Facebook - new tools for scientific networking. Drug Discov. Today 2008, 13:863-868.
    • (2008) Drug Discov. Today , vol.13 , pp. 863-868
    • Bailey, D.S.1    Zanders, E.D.2
  • 5
    • 77949269509 scopus 로고    scopus 로고
    • Reaching out to collaborators: crowdsourcing for pharmaceutical research
    • Ekins S., Williams A.J. Reaching out to collaborators: crowdsourcing for pharmaceutical research. Pharm. Res. 2010, 27:393-395.
    • (2010) Pharm. Res. , vol.27 , pp. 393-395
    • Ekins, S.1    Williams, A.J.2
  • 6
    • 61449194131 scopus 로고    scopus 로고
    • Neglected disease research and development: how much are we really spending?
    • Moran M., et al. Neglected disease research and development: how much are we really spending?. PLoS Med. 2009, 6:e30.
    • (2009) PLoS Med. , vol.6
    • Moran, M.1
  • 7
    • 22244433853 scopus 로고    scopus 로고
    • Health innovation networks to help developing countries address neglected diseases
    • Morel C.M., et al. Health innovation networks to help developing countries address neglected diseases. Science 2005, 309:401-404.
    • (2005) Science , vol.309 , pp. 401-404
    • Morel, C.M.1
  • 8
    • 70449634957 scopus 로고    scopus 로고
    • Predicting new molecular targets for known drugs
    • Keiser M.J., et al. Predicting new molecular targets for known drugs. Nature 2009, 462:175-181.
    • (2009) Nature , vol.462 , pp. 175-181
    • Keiser, M.J.1
  • 9
    • 33644668387 scopus 로고    scopus 로고
    • Finding new tricks for old drugs: an efficient route for public-sector drug discovery
    • O'Connor K.A., Roth B.L. Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat. Rev. Drug Discov. 2005, 4:1005-1014.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 1005-1014
    • O'Connor, K.A.1    Roth, B.L.2
  • 10
    • 2542477991 scopus 로고    scopus 로고
    • Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery
    • Roth B.L., et al. Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacol. Ther. 2004, 102:99-110.
    • (2004) Pharmacol. Ther. , vol.102 , pp. 99-110
    • Roth, B.L.1
  • 11
    • 70449108128 scopus 로고    scopus 로고
    • Antituberculosis activity of the molecular libraries screening center network library
    • Maddry J.A., et al. Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb.) 2009, 89:354-363.
    • (2009) Tuberculosis (Edinb.) , vol.89 , pp. 354-363
    • Maddry, J.A.1
  • 12
    • 70350765485 scopus 로고    scopus 로고
    • High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
    • Ananthan S., et al. High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb.) 2009, 89:334-353.
    • (2009) Tuberculosis (Edinb.) , vol.89 , pp. 334-353
    • Ananthan, S.1
  • 13
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: confronting the challenges of antibacterial discovery
    • Payne D.J., et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 2007, 6:29-40.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1
  • 14
    • 77952704258 scopus 로고    scopus 로고
    • Thousands of chemical starting points for antimalarial lead identification
    • Gamo F.-J., et al. Thousands of chemical starting points for antimalarial lead identification. Nature 2010, 465:305-310.
    • (2010) Nature , vol.465 , pp. 305-310
    • Gamo, F.-J.1
  • 15
    • 18344396568 scopus 로고    scopus 로고
    • Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
    • Brazma A., et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 2001, 29:365-371.
    • (2001) Nat. Genet. , vol.29 , pp. 365-371
    • Brazma, A.1
  • 16
    • 33845620001 scopus 로고    scopus 로고
    • The ToxCast program for prioritizing toxicity testing of environmental chemicals
    • Dix D.J., et al. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol. Sci. 2007, 95:5-12.
    • (2007) Toxicol. Sci. , vol.95 , pp. 5-12
    • Dix, D.J.1
  • 17
    • 77952326917 scopus 로고    scopus 로고
    • A collaborative database and computational models for tuberculosis drug discovery
    • Ekins S., et al. A collaborative database and computational models for tuberculosis drug discovery. Mol. BioSyst. 2010, 6:840-851.
    • (2010) Mol. BioSyst. , vol.6 , pp. 840-851
    • Ekins, S.1
  • 18
    • 76749147365 scopus 로고    scopus 로고
    • Free online resources enabling crowdsourced drug discovery
    • Williams A.J., et al. Free online resources enabling crowdsourced drug discovery. Drug Discovery World, Winter 2009, 10:33-39.
    • (2009) Drug Discovery World, Winter , vol.10 , pp. 33-39
    • Williams, A.J.1
  • 19
    • 0033194752 scopus 로고    scopus 로고
    • Strategic pooling of compounds for high-throughput screening
    • Hann M., et al. Strategic pooling of compounds for high-throughput screening. J. Chem. Inf. Comput. Sci. 1999, 39:897-902.
    • (1999) J. Chem. Inf. Comput. Sci. , vol.39 , pp. 897-902
    • Hann, M.1
  • 20
    • 11844253252 scopus 로고    scopus 로고
    • ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens
    • Huth J.R., et al. ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens. J. Am. Chem. Soc. 2005, 127:217-224.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 217-224
    • Huth, J.R.1
  • 21
    • 38149108462 scopus 로고    scopus 로고
    • Toxicological evaluation of thiol-reactive compounds identified using a La assay to detect reactive molecules by nuclear magnetic resonance
    • Huth J.R., et al. Toxicological evaluation of thiol-reactive compounds identified using a La assay to detect reactive molecules by nuclear magnetic resonance. Chem. Res. Toxicol. 2007, 20:1752-1759.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1752-1759
    • Huth, J.R.1
  • 22
    • 33947194049 scopus 로고    scopus 로고
    • Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups
    • Metz J.T., et al. Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups. J. Comput. Aided Mol. Des. 2007, 21:139-144.
    • (2007) J. Comput. Aided Mol. Des. , vol.21 , pp. 139-144
    • Metz, J.T.1
  • 23
    • 77950571108 scopus 로고    scopus 로고
    • New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
    • Baell J.B., Holloway G.A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 2010, 53:2719-2740.
    • (2010) J. Med. Chem. , vol.53 , pp. 2719-2740
    • Baell, J.B.1    Holloway, G.A.2
  • 24
    • 60549111040 scopus 로고    scopus 로고
    • Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds
    • Axerio-Cilies P., et al. Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds. Eur. J. Med. Chem. 2009, 44:1128-1134.
    • (2009) Eur. J. Med. Chem. , vol.44 , pp. 1128-1134
    • Axerio-Cilies, P.1
  • 25
    • 77957680455 scopus 로고    scopus 로고
    • Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis
    • In Press
    • Ekins, S. et al. (2010) Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis, Mol. BioSyst. In Press, doi:10.1039/c0mb00104j.
    • (2010) Mol. BioSyst.
    • Ekins, S.1
  • 26
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46:3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1
  • 27
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Method 2000, 44:235-249.
    • (2000) J. Pharmacol. Toxicol. Method , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 28
    • 0036589285 scopus 로고    scopus 로고
    • Current trends in lead discovery: are we looking for the appropriate properties?
    • Oprea T.I. Current trends in lead discovery: are we looking for the appropriate properties?. J. Comput. Aided Mol. Des. 2002, 16:325-334.
    • (2002) J. Comput. Aided Mol. Des. , vol.16 , pp. 325-334
    • Oprea, T.I.1
  • 29
    • 0035438391 scopus 로고    scopus 로고
    • Is there a difference between leads and drugs? A historical perspective
    • Oprea T.I., et al. Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 2001, 41:1308-1315.
    • (2001) J. Chem. Inf. Comput. Sci. , vol.41 , pp. 1308-1315
    • Oprea, T.I.1
  • 30
    • 64549160613 scopus 로고    scopus 로고
    • Novel chemical space exploration via natural products
    • Rosen J., et al. Novel chemical space exploration via natural products. J. Med. Chem. 2009, 52:1953-1962.
    • (2009) J. Med. Chem. , vol.52 , pp. 1953-1962
    • Rosen, J.1
  • 31
    • 66149156440 scopus 로고    scopus 로고
    • Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?
    • Ritchie T.J., et al. Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?. J. Chem. Inf. Model. 2009, 49:1025-1032.
    • (2009) J. Chem. Inf. Model. , vol.49 , pp. 1025-1032
    • Ritchie, T.J.1
  • 32
    • 0141923641 scopus 로고    scopus 로고
    • Identification and prediction of promiscuous aggregating inhibitors among known drugs
    • Seidler J., et al. Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 2003, 46:4477-4486.
    • (2003) J. Med. Chem. , vol.46 , pp. 4477-4486
    • Seidler, J.1
  • 33
    • 49949151887 scopus 로고    scopus 로고
    • Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    • Rishton G.M. Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening. Curr. Opin. Chem. Biol. 2008, 12:340-351.
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 340-351
    • Rishton, G.M.1
  • 34
    • 27944441154 scopus 로고    scopus 로고
    • Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
    • Rishton G.M. Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations. Med. Chem. 2005, 1:519-527.
    • (2005) Med. Chem. , vol.1 , pp. 519-527
    • Rishton, G.M.1
  • 35
    • 67650308267 scopus 로고    scopus 로고
    • A crowdsourcing evaluation of the NIH chemical probes
    • Oprea T.I., et al. A crowdsourcing evaluation of the NIH chemical probes. Nat. Chem. Biol. 2009, 5:441-447.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 441-447
    • Oprea, T.I.1
  • 36
    • 47749106894 scopus 로고    scopus 로고
    • Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors
    • Coan K.E., Shoichet B.K. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J. Am. Chem. Soc. 2008, 130:9606-9612.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 9606-9612
    • Coan, K.E.1    Shoichet, B.K.2
  • 37
    • 34249000046 scopus 로고    scopus 로고
    • A high-throughput screen for aggregation-based inhibition in a large compound library
    • Feng B.Y., et al. A high-throughput screen for aggregation-based inhibition in a large compound library. J. Med. Chem. 2007, 50:2385-2390.
    • (2007) J. Med. Chem. , vol.50 , pp. 2385-2390
    • Feng, B.Y.1
  • 38
    • 74849118854 scopus 로고    scopus 로고
    • Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease
    • Jadhav A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J. Med. Chem. 2010, 53:37-51.
    • (2010) J. Med. Chem. , vol.53 , pp. 37-51
    • Jadhav, A.1
  • 39
    • 77952733763 scopus 로고    scopus 로고
    • Colloid formation by drugs in simulated intestinal fluid
    • Doak A.K., et al. Colloid formation by drugs in simulated intestinal fluid. J. Med. Chem. 2010, 53:4259-4265.
    • (2010) J. Med. Chem. , vol.53 , pp. 4259-4265
    • Doak, A.K.1
  • 40
    • 77749317552 scopus 로고    scopus 로고
    • GSK/Sirtris compounds dogged by assay artifacts
    • Schmidt C. GSK/Sirtris compounds dogged by assay artifacts. Nat. Biotechnol. 2010, 28:185-186.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 185-186
    • Schmidt, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.