-
1
-
-
71749108117
-
Competitive collaboration in the pharmaceutical and biotechnology industry
-
Bingham A., Ekins S. Competitive collaboration in the pharmaceutical and biotechnology industry. Drug Discov. Today 2009, 14:1079-1081.
-
(2009)
Drug Discov. Today
, vol.14
, pp. 1079-1081
-
-
Bingham, A.1
Ekins, S.2
-
2
-
-
43049159565
-
The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients
-
Hunter A.J. The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients. Drug Discov. Today 2008, 13:371-373.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 371-373
-
-
Hunter, A.J.1
-
3
-
-
70049099472
-
Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery
-
Barnes M.R., et al. Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat. Rev. Drug Discov. 2009, 8:701-708.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 701-708
-
-
Barnes, M.R.1
-
4
-
-
52049085009
-
Drug discovery in the era of Facebook - new tools for scientific networking
-
Bailey D.S., Zanders E.D. Drug discovery in the era of Facebook - new tools for scientific networking. Drug Discov. Today 2008, 13:863-868.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 863-868
-
-
Bailey, D.S.1
Zanders, E.D.2
-
5
-
-
77949269509
-
Reaching out to collaborators: crowdsourcing for pharmaceutical research
-
Ekins S., Williams A.J. Reaching out to collaborators: crowdsourcing for pharmaceutical research. Pharm. Res. 2010, 27:393-395.
-
(2010)
Pharm. Res.
, vol.27
, pp. 393-395
-
-
Ekins, S.1
Williams, A.J.2
-
6
-
-
61449194131
-
Neglected disease research and development: how much are we really spending?
-
Moran M., et al. Neglected disease research and development: how much are we really spending?. PLoS Med. 2009, 6:e30.
-
(2009)
PLoS Med.
, vol.6
-
-
Moran, M.1
-
7
-
-
22244433853
-
Health innovation networks to help developing countries address neglected diseases
-
Morel C.M., et al. Health innovation networks to help developing countries address neglected diseases. Science 2005, 309:401-404.
-
(2005)
Science
, vol.309
, pp. 401-404
-
-
Morel, C.M.1
-
8
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser M.J., et al. Predicting new molecular targets for known drugs. Nature 2009, 462:175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
-
9
-
-
33644668387
-
Finding new tricks for old drugs: an efficient route for public-sector drug discovery
-
O'Connor K.A., Roth B.L. Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat. Rev. Drug Discov. 2005, 4:1005-1014.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 1005-1014
-
-
O'Connor, K.A.1
Roth, B.L.2
-
10
-
-
2542477991
-
Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery
-
Roth B.L., et al. Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacol. Ther. 2004, 102:99-110.
-
(2004)
Pharmacol. Ther.
, vol.102
, pp. 99-110
-
-
Roth, B.L.1
-
11
-
-
70449108128
-
Antituberculosis activity of the molecular libraries screening center network library
-
Maddry J.A., et al. Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb.) 2009, 89:354-363.
-
(2009)
Tuberculosis (Edinb.)
, vol.89
, pp. 354-363
-
-
Maddry, J.A.1
-
12
-
-
70350765485
-
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
-
Ananthan S., et al. High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb.) 2009, 89:334-353.
-
(2009)
Tuberculosis (Edinb.)
, vol.89
, pp. 334-353
-
-
Ananthan, S.1
-
13
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Payne D.J., et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 2007, 6:29-40.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
-
14
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
Gamo F.-J., et al. Thousands of chemical starting points for antimalarial lead identification. Nature 2010, 465:305-310.
-
(2010)
Nature
, vol.465
, pp. 305-310
-
-
Gamo, F.-J.1
-
15
-
-
18344396568
-
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
-
Brazma A., et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 2001, 29:365-371.
-
(2001)
Nat. Genet.
, vol.29
, pp. 365-371
-
-
Brazma, A.1
-
16
-
-
33845620001
-
The ToxCast program for prioritizing toxicity testing of environmental chemicals
-
Dix D.J., et al. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol. Sci. 2007, 95:5-12.
-
(2007)
Toxicol. Sci.
, vol.95
, pp. 5-12
-
-
Dix, D.J.1
-
17
-
-
77952326917
-
A collaborative database and computational models for tuberculosis drug discovery
-
Ekins S., et al. A collaborative database and computational models for tuberculosis drug discovery. Mol. BioSyst. 2010, 6:840-851.
-
(2010)
Mol. BioSyst.
, vol.6
, pp. 840-851
-
-
Ekins, S.1
-
18
-
-
76749147365
-
Free online resources enabling crowdsourced drug discovery
-
Williams A.J., et al. Free online resources enabling crowdsourced drug discovery. Drug Discovery World, Winter 2009, 10:33-39.
-
(2009)
Drug Discovery World, Winter
, vol.10
, pp. 33-39
-
-
Williams, A.J.1
-
19
-
-
0033194752
-
Strategic pooling of compounds for high-throughput screening
-
Hann M., et al. Strategic pooling of compounds for high-throughput screening. J. Chem. Inf. Comput. Sci. 1999, 39:897-902.
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 897-902
-
-
Hann, M.1
-
20
-
-
11844253252
-
ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens
-
Huth J.R., et al. ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens. J. Am. Chem. Soc. 2005, 127:217-224.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 217-224
-
-
Huth, J.R.1
-
21
-
-
38149108462
-
Toxicological evaluation of thiol-reactive compounds identified using a La assay to detect reactive molecules by nuclear magnetic resonance
-
Huth J.R., et al. Toxicological evaluation of thiol-reactive compounds identified using a La assay to detect reactive molecules by nuclear magnetic resonance. Chem. Res. Toxicol. 2007, 20:1752-1759.
-
(2007)
Chem. Res. Toxicol.
, vol.20
, pp. 1752-1759
-
-
Huth, J.R.1
-
22
-
-
33947194049
-
Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups
-
Metz J.T., et al. Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups. J. Comput. Aided Mol. Des. 2007, 21:139-144.
-
(2007)
J. Comput. Aided Mol. Des.
, vol.21
, pp. 139-144
-
-
Metz, J.T.1
-
23
-
-
77950571108
-
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
-
Baell J.B., Holloway G.A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 2010, 53:2719-2740.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2719-2740
-
-
Baell, J.B.1
Holloway, G.A.2
-
24
-
-
60549111040
-
Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds
-
Axerio-Cilies P., et al. Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds. Eur. J. Med. Chem. 2009, 44:1128-1134.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 1128-1134
-
-
Axerio-Cilies, P.1
-
25
-
-
77957680455
-
Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis
-
In Press
-
Ekins, S. et al. (2010) Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis, Mol. BioSyst. In Press, doi:10.1039/c0mb00104j.
-
(2010)
Mol. BioSyst.
-
-
Ekins, S.1
-
26
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46:3-26.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
-
27
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Method 2000, 44:235-249.
-
(2000)
J. Pharmacol. Toxicol. Method
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
28
-
-
0036589285
-
Current trends in lead discovery: are we looking for the appropriate properties?
-
Oprea T.I. Current trends in lead discovery: are we looking for the appropriate properties?. J. Comput. Aided Mol. Des. 2002, 16:325-334.
-
(2002)
J. Comput. Aided Mol. Des.
, vol.16
, pp. 325-334
-
-
Oprea, T.I.1
-
29
-
-
0035438391
-
Is there a difference between leads and drugs? A historical perspective
-
Oprea T.I., et al. Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 2001, 41:1308-1315.
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1315
-
-
Oprea, T.I.1
-
30
-
-
64549160613
-
Novel chemical space exploration via natural products
-
Rosen J., et al. Novel chemical space exploration via natural products. J. Med. Chem. 2009, 52:1953-1962.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1953-1962
-
-
Rosen, J.1
-
31
-
-
66149156440
-
Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?
-
Ritchie T.J., et al. Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?. J. Chem. Inf. Model. 2009, 49:1025-1032.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 1025-1032
-
-
Ritchie, T.J.1
-
32
-
-
0141923641
-
Identification and prediction of promiscuous aggregating inhibitors among known drugs
-
Seidler J., et al. Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 2003, 46:4477-4486.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4477-4486
-
-
Seidler, J.1
-
33
-
-
49949151887
-
Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
-
Rishton G.M. Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening. Curr. Opin. Chem. Biol. 2008, 12:340-351.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 340-351
-
-
Rishton, G.M.1
-
34
-
-
27944441154
-
Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
-
Rishton G.M. Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations. Med. Chem. 2005, 1:519-527.
-
(2005)
Med. Chem.
, vol.1
, pp. 519-527
-
-
Rishton, G.M.1
-
35
-
-
67650308267
-
A crowdsourcing evaluation of the NIH chemical probes
-
Oprea T.I., et al. A crowdsourcing evaluation of the NIH chemical probes. Nat. Chem. Biol. 2009, 5:441-447.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 441-447
-
-
Oprea, T.I.1
-
36
-
-
47749106894
-
Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors
-
Coan K.E., Shoichet B.K. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J. Am. Chem. Soc. 2008, 130:9606-9612.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 9606-9612
-
-
Coan, K.E.1
Shoichet, B.K.2
-
37
-
-
34249000046
-
A high-throughput screen for aggregation-based inhibition in a large compound library
-
Feng B.Y., et al. A high-throughput screen for aggregation-based inhibition in a large compound library. J. Med. Chem. 2007, 50:2385-2390.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2385-2390
-
-
Feng, B.Y.1
-
38
-
-
74849118854
-
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease
-
Jadhav A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J. Med. Chem. 2010, 53:37-51.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 37-51
-
-
Jadhav, A.1
-
39
-
-
77952733763
-
Colloid formation by drugs in simulated intestinal fluid
-
Doak A.K., et al. Colloid formation by drugs in simulated intestinal fluid. J. Med. Chem. 2010, 53:4259-4265.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4259-4265
-
-
Doak, A.K.1
-
40
-
-
77749317552
-
GSK/Sirtris compounds dogged by assay artifacts
-
Schmidt C. GSK/Sirtris compounds dogged by assay artifacts. Nat. Biotechnol. 2010, 28:185-186.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 185-186
-
-
Schmidt, C.1
|