The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the prpsc-like form

Biochemistry

Volumn 49, Issue 40, 2010, Pages 8729-8738

  Hosszu, Laszlo L P ^a,b   Tattum, M Howard ^a   Jones, Samantha ^a   Trevitt, Clare R ^a,b   Wells, Mark A ^b   Waltho, Jonathan P ^b   Collinge, John ^a   Jackson, Graham S ^a   Clarke, Anthony R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL SWITCHES; HISTIDINE RESIDUES; HUMAN PRION PROTEIN; INTRINSIC INSTABILITY; POSITIVE CHARGES; POSITIVELY CHARGED; PRION DISEASE; PRION PROTEIN; PROTONATED; PROTONATION STATE; SIDE-CHAIN INTERACTIONS;

AMINO ACIDS; PROTEINS; PROTONATION; SCANDIUM; STABILITY;

CONFORMATIONS;

ARGININE; HISTIDINE; PRION PROTEIN; PROTEINASE; RECOMBINANT PROTEIN;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; DISULFIDE BOND; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; INFRARED SPECTROSCOPY; MUTATION; OLIGOMERIZATION; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTON TRANSPORT;

CIRCULAR DICHROISM; DISULFIDES; HUMANS; HYDROGEN-ION CONCENTRATION; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE HYDROLASES; PRION DISEASES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PRPC PROTEINS; PRPSC PROTEINS; RECOMBINANT PROTEINS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; ULTRACENTRIFUGATION;

EID: 77957669973     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100572j     Document Type: Article

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