메뉴 건너뛰기




Volumn 663, Issue , 2010, Pages 157-179

Novel anticoagulant therapy: Principle and practice

Author keywords

Anticoagulants; direct thrombin inhibitors; factor IXa inhibitors; factor Xa inhibitors; pentasaccharide; tissue factor factor VIIa complex inhibitors; venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; THROMBIN;

EID: 77957669137     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-803-4_5     Document Type: Article
Times cited : (18)

References (73)
  • 1
    • 0038042011 scopus 로고    scopus 로고
    • Risk factors for venous thromboembolism
    • Anderson, F.A., Jr., and Spencer, F.A. (2003) Risk factors for venous thromboembolism Circulation 107, I9-16.
    • (2003) Circulation , vol.107
    • Anderson Jr., F.A.1    Spencer, F.A.2
  • 2
    • 0037704209 scopus 로고    scopus 로고
    • Natural history of venous thromboembolism
    • Kearon, C. (2003) Natural history of venous thromboembolism Circulation 107, I22-30.
    • (2003) Circulation , vol.107
    • Kearon, C.1
  • 3
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with lowmolecular- weight heparin or unfractionated heparin
    • Warkentin, T.E., Levine, M.N., Hirsh, J., Horsewood, P., Roberts, R.S., Gent, M., and Kelton, J.G. (1995) Heparin-induced thrombocytopenia in patients treated with lowmolecular- weight heparin or unfractionated heparin N Engl J Med 332, 1330-5.
    • (1995) N Engl J Med , vol.332 , pp. 1330-5
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3    Horsewood, P.4    Roberts, R.S.5    Gent, M.6    Kelton, J.G.7
  • 4
    • 32544447350 scopus 로고    scopus 로고
    • Managing oral anticoagulation requires expert experience and clinical evidence
    • Spyropoulos, A.C. (2006) Managing oral anticoagulation requires expert experience and clinical evidence J Thromb Thromboly 21, 91-4.
    • (2006) J Thromb Thromboly , vol.21 , pp. 91-4
    • Spyropoulos, A.C.1
  • 6
    • 0033850037 scopus 로고    scopus 로고
    • Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: A retrospective analysis
    • Hutten, B.A., Prins, M.H., Gent, M., Ginsberg, J., Tijssen, J.G., and Buller, H.R. (2000) Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: A retrospective analysis J Clin Oncol 18, 3078-83.
    • (2000) J Clin Oncol , vol.18 , pp. 3078-83
    • Hutten, B.A.1    Prins, M.H.2    Gent, M.3    Ginsberg, J.4    Tijssen, J.G.5    Buller, H.R.6
  • 7
    • 0033708930 scopus 로고    scopus 로고
    • A comparison of the safety and efficacy of oral anticoagulation for the treatment of venous thromboembolic disease in patients with or without malignancy
    • Palareti, G., Legnani, C., Lee, A., Manotti, C., Hirsh, J., D'Angelo, A., Pengo, V., Moia, M., and Coccheri, S. (2000) A comparison of the safety and efficacy of oral anticoagulation for the treatment of venous thromboembolic disease in patients with or without malignancy Thromb Haemost 84, 805-10.
    • (2000) Thromb Haemost , vol.84 , pp. 805-10
    • Palareti, G.1    Legnani, C.2    Lee, A.3    Manotti, C.4    Hirsh, J.5    D'Angelo, A.6    Pengo, V.7    Moia, M.8    Coccheri, S.9
  • 8
    • 4644258310 scopus 로고    scopus 로고
    • Use of antithrombotic agents during pregnancy. The seventh ACCP conference on antithrombotic and thrombolytic therapy
    • Bates, S., Greer, I., Hirsch, J., and Ginsberg, J. (2004) Use of antithrombotic agents during pregnancy. The seventh ACCP conference on antithrombotic and thrombolytic therapy Chest 126, 627S-44S.
    • (2004) Chest , vol.126
    • Bates, S.1    Greer, I.2    Hirsch, J.3    Ginsberg, J.4
  • 9
    • 22144466236 scopus 로고    scopus 로고
    • Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: A systematic review of safety and efficacy
    • Greer, I.A., and Nelson-Piercy, C. (2005) Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: A systematic review of safety and efficacy Blood 106, 401-7.
    • (2005) Blood , vol.106 , pp. 401-7
    • Greer, I.A.1    Nelson-Piercy, C.2
  • 11
    • 4644248591 scopus 로고    scopus 로고
    • New anticoagulant drugs. The seventh ACCP conference on antithrombotic and thrombolytic therapy
    • Weitz, J.I., Hirsh, J., and Samama, M. (2004) New anticoagulant drugs. The seventh ACCP conference on antithrombotic and thrombolytic therapy Chest 126, 265S- 86S.
    • (2004) Chest , vol.126
    • Weitz, J.I.1    Hirsh, J.2    Samama, M.3
  • 12
    • 0032719688 scopus 로고    scopus 로고
    • Mechanisms of hypercoagulability
    • Dahl, O.E. (1999) Mechanisms of hypercoagulability Thromb Haemost 82, 902-6.
    • (1999) Thromb Haemost , vol.82 , pp. 902-6
    • Dahl, O.E.1
  • 14
    • 0035321911 scopus 로고    scopus 로고
    • The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation
    • Girard, T.J., and Nicholson, N.S. (2001) The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation Curr Opin Pharmacol 1, 159-63.
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 159-63
    • Girard, T.J.1    Nicholson, N.S.2
  • 17
    • 4544370585 scopus 로고    scopus 로고
    • Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor
    • Mousa, S.A., and Mohamed, S. (2004) Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor Thromb Haemost 92, 627-33.
    • (2004) Thromb Haemost , vol.92 , pp. 627-33
    • Mousa, S.A.1    Mohamed, S.2
  • 18
    • 0035800075 scopus 로고    scopus 로고
    • Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
    • Lee, A., Agnelli, G., Buller, H., Ginsberg, J., Heit, J., Rote, W., Vlasuk, G., Costantini, L., Julian, J., Comp, P., van Der Meer, J., Piovella, F., Raskob, G., and Gent, M. (2001) Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement Circulation 104, 74-8.
    • (2001) Circulation , vol.104 , pp. 74-8
    • Lee, A.1    Agnelli, G.2    Buller, H.3    Ginsberg, J.4    Heit, J.5    Rote, W.6    Vlasuk, G.7    Costantini, L.8    Julian, J.9    Comp, P.10    Van Der Meer, J.11    Piovella, F.12    Raskob, G.13    Gent, M.14
  • 20
    • 0037971568 scopus 로고    scopus 로고
    • Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty
    • Moons, A.H., Peters, R.J., Bijsterveld, N.R., Piek, J.J., Prins, M.H., Vlasuk, G.P., Rote, W.E., and Buller, H.R. (2003) Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty J Am Coll Cardiol 41, 2147-53.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2147-53
    • Moons, A.H.1    Peters, R.J.2    Bijsterveld, N.R.3    Piek, J.J.4    Prins, M.H.5    Vlasuk, G.P.6    Rote, W.E.7    Buller, H.R.8
  • 21
    • 0025875990 scopus 로고
    • The structural biology of expression and function of tissue factor
    • Edgington, T.S., Mackman, N., Brand, K., and Ruf, W. (1991) The structural biology of expression and function of tissue factor Thromb Haemost 66, 67-79.
    • (1991) Thromb Haemost , vol.66 , pp. 67-79
    • Edgington, T.S.1    Mackman, N.2    Brand, K.3    Ruf, W.4
  • 22
    • 29244487521 scopus 로고    scopus 로고
    • The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor
    • Arnold, C.S., Parker, C., Upshaw, R., Prydz, H., Chand, P., Kotian, P., Bantia, S., and Babu, Y.S. (2006) The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor Thromb Res 117, 343-9.
    • (2006) Thromb Res , vol.117 , pp. 343-9
    • Arnold, C.S.1    Parker, C.2    Upshaw, R.3    Prydz, H.4    Chand, P.5    Kotian, P.6    Bantia, S.7    Babu, Y.S.8
  • 23
    • 4444282406 scopus 로고    scopus 로고
    • Inhibitors of tissue factor. Factor VIIa for anticoagulant therapy
    • Lazarus, R.A., Olivero, A.G., Eigenbrot, C., and Kirchhofer, D. (2004) Inhibitors of tissue factor. Factor VIIa for anticoagulant therapy Curr Med Chem 11, 2275-90.
    • (2004) Curr Med Chem , vol.11 , pp. 2275-90
    • Lazarus, R.A.1    Olivero, A.G.2    Eigenbrot, C.3    Kirchhofer, D.4
  • 25
    • 0041932150 scopus 로고    scopus 로고
    • Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: Comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model
    • Suleymanov, O.D., Szalony, J.A., Salyers, A.K., LaChance, R.M., Parlow, J.J., South, M.S., Wood, R.S., and Nicholson, N.S. (2003) Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: Comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model J Pharmacol Exp Ther 306, 1115-21.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 1115-21
    • Suleymanov, O.D.1    Szalony, J.A.2    Salyers, A.K.3    LaChance, R.M.4    Parlow, J.J.5    South, M.S.6    Wood, R.S.7    Nicholson, N.S.8
  • 26
    • 0030745177 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor: Potential therapeutic applications
    • Bajaj, M.S., and Bajaj, S.P. (1997) Tissue factor pathway inhibitor: Potential therapeutic applications Thromb Haemost 78, 471-7.
    • (1997) Thromb Haemost , vol.78 , pp. 471-7
    • Bajaj, M.S.1    Bajaj, S.P.2
  • 27
    • 1842828919 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor in thrombosis and beyond
    • Mousa, S.A., Fareed, J., Iqbal, O., and Kaiser, B. (2004) Tissue factor pathway inhibitor in thrombosis and beyond Methods Mol Med 93, 133-55.
    • (2004) Methods Mol Med , vol.93 , pp. 133-55
    • Mousa, S.A.1    Fareed, J.2    Iqbal, O.3    Kaiser, B.4
  • 28
    • 0023778170 scopus 로고
    • Heparin induces release of extrinsic coagulation pathway inhibitor (EPI
    • Sandset, P.M., Abildgaard, U., and Larsen, M.L. (1988) Heparin induces release of extrinsic coagulation pathway inhibitor (EPI) Thromb Res 50, 803-13.
    • (1988) Thromb Res , vol.50 , pp. 803-13
    • Sandset, P.M.1    Abildgaard, U.2    Larsen, M.L.3
  • 30
    • 33845357884 scopus 로고    scopus 로고
    • Anti-metastatic effect of a non-anticoagulant low-molecularweight heparin versus the standard lowmolecular- weight heparin, enoxaparin
    • Mousa, S.A., Linhardt, R., Francis, J.L., and Amirkhosravi, A. (2006) Anti-metastatic effect of a non-anticoagulant low-molecularweight heparin versus the standard lowmolecular- weight heparin, enoxaparin Thromb Haemost 96, 816-21.
    • (2006) Thromb Haemost , vol.96 , pp. 816-21
    • Mousa, S.A.1    Linhardt, R.2    Francis, J.L.3    Amirkhosravi, A.4
  • 31
    • 36349029749 scopus 로고    scopus 로고
    • The role of tissue factor pathway inhibitor-2 in cancer biology
    • Sierko, E., Wojtukiewicz, M.Z., and Kisiel, W. (2007) The role of tissue factor pathway inhibitor-2 in cancer biology Semin Thromb Hemost 33, 653-9.
    • (2007) Semin Thromb Hemost , vol.33 , pp. 653-9
    • Sierko, E.1    Wojtukiewicz, M.Z.2    Kisiel, W.3
  • 32
    • 0030022915 scopus 로고    scopus 로고
    • Comparison of sustained antithrombotic effects of inhibitors of thrombin and factor Xa in experimental thrombosis
    • Biemond, B.J., Friederich, P.W., Levi, M., Vlasuk, G.P., Buller, H.R., and ten Cate, J.W. (1996) Comparison of sustained antithrombotic effects of inhibitors of thrombin and factor Xa in experimental thrombosis Circulation 93, 153-60.
    • (1996) Circulation , vol.93 , pp. 153-60
    • Biemond, B.J.1    Friederich, P.W.2    Levi, M.3    Vlasuk, G.P.4    Buller, H.R.5    Ten Cate, J.W.6
  • 40
    • 11244325810 scopus 로고    scopus 로고
    • A phase II randomized, doubleblind, five-arm, parallel group, dose-response study of a new oral directly-acting factor Xa inhibitor, razaxaban, foe the prevention of deep vein thrombosis in knee replacement surgery
    • Abstract 41
    • Lassen, M., Davidson, B., Gallus, A., Pineo, G., Ansell, J., and Deitchman, D.B.a.A. (2003) A phase II randomized, doubleblind, five-arm, parallel group, dose-response study of a new oral directly-acting factor Xa inhibitor, razaxaban, foe the prevention of deep vein thrombosis in knee replacement surgery Blood 102, Abstract 41.
    • (2003) Blood , vol.102
    • Lassen, M.1    Davidson, B.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.B.A.A.6
  • 41
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen, M.R., Davidson, B.L., Gallus, A., Pineo, G., Ansell, J., and Deitchman, D. (2007) The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement J Thromb Haemost 5, 2368-75.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-75
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 42
  • 43
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza, D., Becka, M., Voith, B., Zuehlsdorf, M., and Wensing, G. (2005) Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor Clin Pharmacol Ther 78, 412-21.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-21
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 44
    • 33644867218 scopus 로고    scopus 로고
    • Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement
    • Eriksson, B.I., Borris, L., Dahl, O.E., Haas, S., Huisman, M.V., Kakkar, A.K., Misselwitz, F., and Kalebo, P. (2006) Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement J Thromb Haemost 4, 121-8.
    • (2006) J Thromb Haemost , vol.4 , pp. 121-8
    • Eriksson, B.I.1    Borris, L.2    Dahl, O.E.3    Haas, S.4    Huisman, M.V.5    Kakkar, A.K.6    Misselwitz, F.7    Kalebo, P.8
  • 45
    • 28444474155 scopus 로고    scopus 로고
    • BAY 59- 7939: An oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study
    • Turpie, A.G., Fisher, W.D., Bauer, K.A., Kwong, L.M., Irwin, M.W., Kalebo, P., Misselwitz, F., and Gent, M. (2005) BAY 59- 7939: An oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study J Thromb Haemost 3, 2479-86.
    • (2005) J Thromb Haemost , vol.3 , pp. 2479-86
    • Turpie, A.G.1    Fisher, W.D.2    Bauer, K.A.3    Kwong, L.M.4    Irwin, M.W.5    Kalebo, P.6    Misselwitz, F.7    Gent, M.8
  • 46
    • 34547106820 scopus 로고    scopus 로고
    • Preclinical and clinical characteristics of rivaroxaban: A novel, oral, direct factor Xa inhibitor
    • Laux, V., Perzborn, E., Kubitza, D., and Misselwitz, F. (2007) Preclinical and clinical characteristics of rivaroxaban: A novel, oral, direct factor Xa inhibitor Semin Thromb Hemost 33, 515-23.
    • (2007) Semin Thromb Hemost , vol.33 , pp. 515-23
    • Laux, V.1    Perzborn, E.2    Kubitza, D.3    Misselwitz, F.4
  • 47
    • 0034871011 scopus 로고    scopus 로고
    • A systematic review of the associations between dose regimens and medication compliance
    • Claxton, A.J., Cramer, J., and Pierce, C. (2001) A systematic review of the associations between dose regimens and medication compliance Clin Ther 23, 1296-310.
    • (2001) Clin Ther , vol.23 , pp. 1296-310
    • Claxton, A.J.1    Cramer, J.2    Pierce, C.3
  • 48
    • 0041384468 scopus 로고    scopus 로고
    • The impact of reducing dose frequency on health outcomes
    • Discussion 6
    • Richter, A., Anton, S.E., Koch, P., and Dennett, S.L. (2003) The impact of reducing dose frequency on health outcomes Clin Ther 25, 2307-35, Discussion 6.
    • (2003) Clin Ther , vol.25 , pp. 2307-35
    • Richter, A.1    Anton, S.E.2    Koch, P.3    Dennett, S.L.4
  • 50
    • 34447639584 scopus 로고    scopus 로고
    • A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
    • Eriksson, B.I., Turpie, A.G., Lassen, M.R., Prins, M.H., Agnelli, G., Kalebo, P., Gaillard, M.L., and Meems, L. (2007) A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery J Thromb Haemost 5, 1660-5.
    • (2007) J Thromb Haemost , vol.5 , pp. 1660-5
    • Eriksson, B.I.1    Turpie, A.G.2    Lassen, M.R.3    Prins, M.H.4    Agnelli, G.5    Kalebo, P.6    Gaillard, M.L.7    Meems, L.8
  • 51
    • 33744813185 scopus 로고    scopus 로고
    • YM150, an oral direct factor Xa inhibitor, as prophylaxis for venous thromboembolism in patients with elective primary hip replacement surgery. A dose escalation study
    • Eriksson, B.I., Turpie, A., Lassen, M., Prins, M., Agnelli, G., Gaillard, M., and Meems, B. (2005) YM150, an oral direct factor Xa inhibitor, as prophylaxis for venous thromboembolism in patients with elective primary hip replacement surgery. A dose escalation study Bood 106, 1865.
    • (2005) Bood , vol.106 , pp. 1865
    • Eriksson, B.I.1    Turpie, A.2    Lassen, M.3    Prins, M.4    Agnelli, G.5    Gaillard, M.6    Meems, B.7
  • 52
    • 34249326422 scopus 로고    scopus 로고
    • Impact of antithrombin deficiency on efficiencies of DU-176b, a novel orally active direct factor Xa inhibitor, and antithrombin dependent anticoagulants, fondaparinux, and heparin
    • Fukuda, F., Honda, Y., Matsumoto, C., Sugiyama, N., Matsushita, T., Yanada, M., Morishima, Y., and Shibano, T. (2005) Impact of antithrombin deficiency on efficiencies of DU-176b, a novel orally active direct factor Xa inhibitor, and antithrombin dependent anticoagulants, fondaparinux, and heparin Blood 106, 1874.
    • (2005) Blood , vol.106 , pp. 1874
    • Fukuda, F.1    Honda, Y.2    Matsumoto, C.3    Sugiyama, N.4    Matsushita, T.5    Yanada, M.6    Morishima, Y.7    Shibano, T.8
  • 53
    • 33744787541 scopus 로고    scopus 로고
    • A phase II study of the safety and efficacy of a novel oral fXa inhibitor (LY517717) for the prevention of venous thromboembolism following TKR or THR
    • Agnelli, G., Haas, S., Krueger, K., Bedding, A., and Brandt, J. (2005) A phase II study of the safety and efficacy of a novel oral fXa inhibitor (LY517717) for the prevention of venous thromboembolism following TKR or THR Blood 106, 85a.
    • (2005) Blood , vol.106
    • Agnelli, G.1    Haas, S.2    Krueger, K.3    Bedding, A.4    Brandt, J.5
  • 54
    • 34247219508 scopus 로고    scopus 로고
    • TTP889, a novel orally active partial inhibitor of FIXa inhibits clotting in two A/V shunt models without prolonged bleeding
    • Rothlein, R., Shen, J., Naser, N., Gohimukkula, D., Caligan, T., Andrews, R., Schmidt, A., Rose, E., and Mjalli, A. (2005) TTP889, a novel orally active partial inhibitor of FIXa inhibits clotting in two A/V shunt models without prolonged bleeding Blood 106, 1886.
    • (2005) Blood , vol.106 , pp. 1886
    • Rothlein, R.1    Shen, J.2    Naser, N.3    Gohimukkula, D.4    Caligan, T.5    Andrews, R.6    Schmidt, A.7    Rose, E.8    Mjalli, A.9
  • 57
    • 0032552897 scopus 로고    scopus 로고
    • Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans
    • Baughman, R.A., Kapoor, S.C., Agarwal, R.K., Kisicki, J., Catella-Lawson, F., and FitzGerald, G.A. (1998) Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans Circulation 98, 1610-5.
    • (1998) Circulation , vol.98 , pp. 1610-5
    • Baughman, R.A.1    Kapoor, S.C.2    Agarwal, R.K.3    Kisicki, J.4    Catella-Lawson, F.5    FitzGerald, G.A.6
  • 58
    • 0141765275 scopus 로고    scopus 로고
    • PROTECT trial: Oral SNAC-heparin vs enoxaparin for preventing venous thromboembolism following total hip replacement
    • Hull, D., Kakkar, A., Marder, V., Pineo, G.F., Goldberg, M., and Raskob, G. (2001) PROTECT trial: Oral SNAC-heparin vs enoxaparin for preventing venous thromboembolism following total hip replacement. Blood 100, 148-9a.
    • (2001) Blood , vol.100
    • Hull, D.1    Kakkar, A.2    Marder, V.3    Pineo, G.F.4    Goldberg, M.5    Raskob, G.6
  • 59
    • 34249914210 scopus 로고    scopus 로고
    • Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anticoagulant
    • Kim, S.K., Lee, D.Y., Lee, E., Lee, Y.K., Kim, C.Y., Moon, H.T., and Byun, Y. (2007) Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anticoagulant J Control Release 120, 4-10.
    • (2007) J Control Release , vol.120 , pp. 4-10
    • Kim, S.K.1    Lee, D.Y.2    Lee, E.3    Lee, Y.K.4    Kim, C.Y.5    Moon, H.T.6    Byun, Y.7
  • 61
    • 13544261745 scopus 로고    scopus 로고
    • The pathophysiology of heparin-induced thrombocytopenia: Biological basis for treatment
    • Kelton, J.G. (2005) The pathophysiology of heparin-induced thrombocytopenia: Biological basis for treatment Chest 127, 9-20S.
    • (2005) Chest , vol.127
    • Kelton, J.G.1
  • 62
    • 0025146426 scopus 로고
    • Clotbound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin IIIindependent inhibitors
    • Weitz, J.I., Hudoba, M., Massel, D., Maraganore, J., and Hirsh, J. (1990) Clotbound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin IIIindependent inhibitors J Clin Invest 86, 385-91.
    • (1990) J Clin Invest , vol.86 , pp. 385-91
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3    Maraganore, J.4    Hirsh, J.5
  • 63
    • 0035894619 scopus 로고    scopus 로고
    • Effect of different types of thrombin inhibitors on thrombin/ thrombomodulin modulated activation of protein C in vitro
    • Mattsson, C., Menschik-Lundin, A., Nylander, S., Gyzander, E., and Deinum, J. (2001) Effect of different types of thrombin inhibitors on thrombin/thrombomodulin modulated activation of protein C in vitro Thromb Res 104, 475-86.
    • (2001) Thromb Res , vol.104 , pp. 475-86
    • Mattsson, C.1    Menschik-Lundin, A.2    Nylander, S.3    Gyzander, E.4    Deinum, J.5
  • 64
    • 0742284689 scopus 로고    scopus 로고
    • The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: The EXPRESS study
    • Eriksson, B.I., Agnelli, G., Cohen, A.T., Dahl, O.E., Lassen, M.R., Mouret, P., Rosencher, N., Kalebo, P., Panfilov, S., Eskilson, C., Andersson, M., and Freij, A. (2003) The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: The EXPRESS study J Thromb Haemost 1, 2490-6.
    • (2003) J Thromb Haemost , vol.1 , pp. 2490-6
    • Eriksson, B.I.1    Agnelli, G.2    Cohen, A.T.3    Dahl, O.E.4    Lassen, M.R.5    Mouret, P.6    Rosencher, N.7    Kalebo, P.8    Panfilov, S.9    Eskilson, C.10    Andersson, M.11    Freij, A.12
  • 65
    • 0037329702 scopus 로고    scopus 로고
    • Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement
    • Eriksson, B.I., Agnelli, G., Cohen, A.T., Dahl, O.E., Mouret, P., Rosencher, N., Eskilson, C., Nylander, I., Frison, L., and Ogren, M. (2003) Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement Thromb Haemost 89, 288-96.
    • (2003) Thromb Haemost , vol.89 , pp. 288-96
    • Eriksson, B.I.1    Agnelli, G.2    Cohen, A.T.3    Dahl, O.E.4    Mouret, P.5    Rosencher, N.6    Eskilson, C.7    Nylander, I.8    Frison, L.9    Ogren, M.10
  • 69
    • 0142182558 scopus 로고    scopus 로고
    • Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran
    • Schulman, S., Wahlander, K., Lundstrom, T., Clason, S.B., and Eriksson, H. (2003) Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran N Engl J Med 349, 1713-21.
    • (2003) N Engl J Med , vol.349 , pp. 1713-21
    • Schulman, S.1    Wahlander, K.2    Lundstrom, T.3    Clason, S.B.4    Eriksson, H.5
  • 70
    • 0141737813 scopus 로고    scopus 로고
    • Pharmacokinetics of BIBR 953 ZW, a novel low molecular weight direct thrombin inhibitor in healthy volunteers. Abstract
    • Stangier, J., Rathgen, K., Gansser, D., Kohlbrenner, V., and Stassen, J. (2001) Pharmacokinetics of BIBR 953 ZW, a novel low molecular weight direct thrombin inhibitor in healthy volunteers. Abstract Thromb Haemost 86, OC2347.
    • (2001) Thromb Haemost , vol.86
    • Stangier, J.1    Rathgen, K.2    Gansser, D.3    Kohlbrenner, V.4    Stassen, J.5
  • 71
    • 17644409026 scopus 로고    scopus 로고
    • A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: The BISTRO II randomized trial
    • Eriksson, B.I., Dahl, O.E., Buller, H.R., Hettiarachchi, R., Rosencher, N., Bravo, M.L., Ahnfelt, L., Piovella, F., Stangier, J., Kalebo, P., and Reilly, P. (2005) A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: The BISTRO II randomized trial J Thromb Haemost 3, 103-11.
    • (2005) J Thromb Haemost , vol.3 , pp. 103-11
    • Eriksson, B.I.1    Dahl, O.E.2    Buller, H.R.3    Hettiarachchi, R.4    Rosencher, N.5    Bravo, M.L.6    Ahnfelt, L.7    Piovella, F.8    Stangier, J.9    Kalebo, P.10    Reilly, P.11
  • 73
    • 33744817832 scopus 로고    scopus 로고
    • A phase I double-blind, ascending dose study of an oral synthetic direct thrombin inhibitor, TGN167
    • Coombe, S., Allen, G., and Kennedy, A. (2005) A phase I double-blind, ascending dose study of an oral synthetic direct thrombin inhibitor, TGN167 Blood 106, 530a.
    • (2005) Blood , vol.106
    • Coombe, S.1    Allen, G.2    Kennedy, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.