The neuronal-specific SGK1.1 kinase regulates δ-epithelial Na + channel independently of PY motifs and couples it to phospholipase C signaling

American Journal of Physiology - Cell Physiology

Volumn 299, Issue 4, 2010, Pages

  Wesch, Diana ^a,b   Miranda, Pablo ^a,b   Afonso Oramas, Domingo ^b   Althaus, Mike ^c   Castro Hernández, Javier ^b   Dominguez, Jaime ^a   Morty, Rory E ^d   Clauss, Wolfgang ^c   González Hernández, Tomás ^b   De La Rosa, Diego Alvarez ^b   Giraldez, Teresa ^a  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

Serum and glucocorticoid induced kinase 1; Voltage independent Na + channel

Indexed keywords

AMILORIDE; DELTA EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMALL CYTOPLASMIC RNA; UNCLASSIFIED DRUG; IMMEDIATE EARLY PROTEIN; ISOPROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL HYPOXIA; CELL MEMBRANE; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME SPECIFICITY; EPITHELIUM CELL; FEMALE; HETEROLOGOUS EXPRESSION; IN SITU HYBRIDIZATION; INFLAMMATION; KIDNEY EPITHELIUM; MACACA; MALE; MOLECULAR CLONING; MUTAGENESIS; NERVE CELL; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PYRAMIDAL NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; GENETICS; HUMAN; MACACA FASCICULARIS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CEREBRAL CORTEX; EPITHELIAL SODIUM CHANNEL; HUMANS; IMMEDIATE-EARLY PROTEINS; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; OOCYTES; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES; XENOPUS LAEVIS; EPITHELIAL SODIUM CHANNELS;

MACACA FASCICULARIS;

EID: 77957666791     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00184.2010     Document Type: Article

References (43)

1. Almeida RD, Manadas BJ, Melo CV, Gomes JR, Mendes CS, Graos MM, Carvalho RF, Carvalho AP, Duarte CB. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ 12: 1329-1343, 2005.
2. Alvarez de la Rosa D, Canessa CM. Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells. Am J Physiol Cell Physiol 284: C404-C414, 2003.
3. Alvarez de la Rosa D, Canessa CM, Fyfe GK, Zhang P. Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol 62: 573-594, 2000.
4. Alvarez de la Rosa D, Paunescu TG, Els WJ, Helman SI, Canessa CM. Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells. J Gen Physiol 124: 395-407, 2004.
5. Alvarez de la Rosa D, Zhang P, Naray-Fejes-Toth A. Fejes-Toth G, Canessa CM. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem 274: 37834-37839, 1999. (Pubitemid 30026848)
6. Arteaga MF, Alvarez de la Rosa D, Alvarez JA, Canessa CM. Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell 18: 2072-2080, 2007.
7. Arteaga MF, Coric T, Straub C, Canessa CM. A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. Proc Natl Acad Sci USA 105: 4459-4464, 2008. (Pubitemid 351754402)
8. Bird MK, Lawrence AJ. Group I metabotropic glutamate receptors: involvement in drug-seeking and drug-induced plasticity. Curr Mol Pharmacol 2: 83-94, 2009.
9. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76: 99-125, 2005.
10. + channel is made of three homologous subunits. Nature 367: 463-467, 1994.
11. Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Munster C, Chraibi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20: 7052-7059, 2001.
12. Giraldez T, Afonso-Oramas D, Cruz-Muros I, Garcia-Marin V, Pagel P, Gonzalez-Hernandez T, Alvarez de la Rosa D. Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon. J Neurochem 102: 1304-1315, 2007. (Pubitemid 47174233)
13. 2+ oscillations in GH3 rat anterior pituitary cells. Cell Calcium 31: 65-78, 2002.
14. Giraldez T, Hughes TE, Sigworth FJ. Generation of functional fluorescent BK channels by random insertion of GFP variants. J Gen Physiol 126: 429-438, 2005. (Pubitemid 41565859)
15. Gonzalez MC, Abreu P, Barroso-Chinea P, Cruz-Muros I, Gonzalez- Hernandez T. Effect of intracerebroventricular injection of lipopolysaccharide on the tuberoinfundibular dopaminergic system of the rat. Neuroscience 127: 251-259, 2004. (Pubitemid 38829170)
16. Gulledge AT, Bucci DJ, Zhang SS, Matsui M, Yeh HH. M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. J Neurosci 29: 9888-9902, 2009.
17. Haerteis S, Krueger B, Korbmacher C, Rauh R. The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. J Biol Chem 284: 29024-29040, 2009.
18. 2+ requirement, and regulation of M current. J Gen Physiol 126: 243-262, 2005.
19. Ji HL, Benos DJ. Degenerin sites mediate proton activation of delta-beta-gamma-ENaC. J Biol Chem 279: 26939-26947, 2004.
20. Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ. Delta-subunit confers novel biophysical features to alpha beta gammahuman epithelial sodium channel (ENaC) via a physical interaction. J Biol Chem 281: 8233-8241, 2006. (Pubitemid 43847444)
21. + channel. FASEB J 15: 204-214, 2001.
22. Kaufer D, Ogle WO, Pincus ZS, Clark KL, Nicholas AC, Dinkel KM, Dumas TC, Ferguson D, Lee AL, Winters MA, Sapolsky RM. Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci 7: 947-953, 2004. (Pubitemid 39129503)
23. 2. FASEB J 19: 142-143, 2005.
24. Lang F, Artunc F, Vallon V. The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 18: 439-448, 2009.
25. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006. (Pubitemid 44521650)
26. Lassmann T, Sonnhammer EL. Kalign, Kalignvu and Mumsa: web servers for multiple sequence alignment. Nucleic Acids Res 34: W596-W599, 2006.
27. Liu W, Yuen EY, Yan Z. The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex. J Biol Chem 285: 6101-6108, 2010.
28. Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129: 371-383, 2007. (Pubitemid 46574966)
29. McNicholas CM, Canessa CM. Diversity of channels generated by different combinations of epithelial sodium channel subunits. J Gen Physiol 109: 681-692, 1997.
30. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18: 3024-3033, 1999. (Pubitemid 29255611)
31. Pearce D. SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem 13: 13-20, 2003. (Pubitemid 36359377)
32. Pochynyuk O, Bugaj V, Stockand JD. Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 17: 533-540, 2008.
33. Raikwar NS, Snyder PM, Thomas CP. An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function. Am J Physiol Renal Physiol 295: F1440-F1448, 2008.
34. Ruffieux-Daidie D, Poirot O, Boulkroun S, Verrey F, Kellenberger S, Staub O. Deubiquitylation regulates activation and proteolytic cleavage of ENaC. J Am Soc Nephrol 19: 2170-2180, 2008.
35. + channel. J Biol Chem 277: 5-8, 2002.
36. + channel deleted in Liddle's syndrome. EMBO J 15: 2371-2380, 1996.
37. Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol 565: 391-401, 2005. (Pubitemid 40872470)
38. Van-Ham I, Lupu-Meiri M, Tayer M, Shapira H, Oron Y. Response to lysophosphatidic acid in Xenopus oocytes and its rapid desensitization: the role of Gq and Go G-protein families. J Cell Physiol 200: 125-133, 2004. (Pubitemid 38720628)
39. Vuagniaux G, Vallet V, Jaeger NF, Hummler E, Rossier BC. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes. J Gen Physiol 120: 191-201, 2002. (Pubitemid 34857968)
40. Waldegger S, Barth P, Raber G, Lang F. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 94: 4440-4445, 1997. (Pubitemid 27194260)
41. Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M. Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem 270: 27411-27414, 1995.
42. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13: 2031-2040, 1993.
43. + channel delta-subunit in the human brain. Biochem Biophys Res Commun 349: 317-321, 2006.