A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 11, 2008, Pages 4459-4464

  Arteaga, Maria F ^a   Coric, Tatjana ^a   Straub, Christoph ^a   Canessa, Cecilia M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative promoter; Proton activated channel; Serum and glucocorticoid induced kinase

Indexed keywords

ACID SENSING ION CHANNEL; BRAIN PROTEIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1.1; ASIC CHANNEL; IMMEDIATE EARLY PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; PHOSPHATIDYLINOSITOL PHOSPHATE, PTDINS(4,5)P2; POLYPHOSPHOINOSITIDE; PROTEIN SERINE THREONINE KINASE; SERUM GLUCOCORTICOID REGULATED KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DAMAGE; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CELL LINE; CELL MEMBRANE; CHEMISTRY; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CELL LINE; CELL MEMBRANE; CRICETINAE; IMMEDIATE-EARLY PROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; ORGAN SPECIFICITY; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SODIUM CHANNELS;

EID: 41949134496     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800958105     Document Type: Article

References (31)

1. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031-2040.
2. Waldegger S, Barth P, Raber G, Lang F (1997) Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 94:4440-4445.
3. Chen SY, et al. (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96:2514-2595.
4. + retention in the sgk1-knockout mouse. J Clin Invest 110:1263-1268.
5. Brunet A, et al. (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21:952-965.
6. Hertweck M, Gobel C, Baumeister R (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6:577-588.
7. Nishida Y, et al. (2004) Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res Mol Brain Res 123:121-125.
8. Imaizumi K, Tsuda M, Wanaka A, Tohyama M, Takagi T (1994) Differential expression of sgk mRNA, amember of the Ser/Thr protein kinase gene family, in rat brain after CNS injury. Brain Res Mol Brain Res 26:189-196.
9. Iwata S, Nomoto M, Morioka H, Miyata A (2004) Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse 51:279-286.
10. Stichel CC, et al. (2005) sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson's disease. Eur J Neurosci 21:301-316.
11. Schoenebeck B, Bader V, Zhu XR, Schmitz B, Lubbert H (2005) Sgk1, a cell survival response in neurodegenerative diseases. Mol Cell Neurosci 30:249-264.
12. Tudor M, Akbarian S, Chen RZ, Jaenisch R (2002) Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci USA 99:15536-15541.
13. Nuber UA, et al. (2005) Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet 14:2247-2256.
14. Rangone H, et al. (2004) The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. Eur J Neurosci 19:273-279.
15. Géranton SM, Morenilla-Palao C, Hunt SP (2007) A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoidinducible kinase 1 in the induction of inflammatory pain states. J Neurosci 27:6163-6173.
16. Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH (2002) sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc Natl Acad Sci USA 99:3990-3995.
17. Chao CC, Ma YM, Lee EH (2007) Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1. J Neurosci 27:6243-6248.
18. Von Hertzen LS, Giese K (2006) Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. J Neurosci 25:1935-1942.
19. Ma YL, Tsai MC, Hsu WL, Lee EH (2006) SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. Learn Mem 13:114-118.
20. Lang F, et al. (2006) (Patho)physiological significance of the serum- and glucocorticoidinducible kinase isoforms. Physiol Rev 86:1151-1178.
21. Firestone GL, Giampaolo JR, O'Keeffe BA (2003) Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12.
22. Arteaga MF, Wang L, Ravid T, Hochstrasser M, Canessa CM (2006) An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci USA 103:11178-11183.
23. Arteaga MF, Alvarez de la Rosa D, Alvarez JA, Canessa CM (2007) Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell 18:2072-2078.
24. Heo WD, et al. (2006) PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314:1458-1460.
25. Kobayashi T, Cohen P (1999) Activation of serum- and glucocorticoid- regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339:319-328.
26. + transport. Am J Physiol Renal Physiol 283:F377-F387.
27. Náray-Fejes-Tóth A, Helms MN, Stokes JB, Fejes-Tóth G (2004) Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: Structure/function studies. Mol Cell Endocrinol 217:197-202.
28. West AE, et al. (2001) Calcium regulation of neuronal gene expression. Proc Natl Acad Sci USA 98:11024-11031.
29. Bogusz AM, Brickley DR, Pew T, Conzen SD (2006) A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS J 273:2913-2928.
30. Xu J, Liu D, Gill G, Songyang Z (2001) Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositid. J Cell Biol 154:699-705.
31. Coric T, Zhang P, Todorovic N, Canessa CM (2003) The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J Biol Chem 278:45240-45247.