Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism

Brain Research Bulletin

Volumn 83, Issue 5, 2010, Pages 292-296

  Hagenacker, Tim ^a   Hillebrand, Imke ^a   Büsselberg, Dietrich ^b   Schäfers, Maria ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

Flavonoids; Myricetin; Neuropathic pain; Patch clamp; Voltage activated potassium channels

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MYRICETIN; POTASSIUM CHANNEL;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; ENZYME INHIBITORS; FLAVONOIDS; GANGLIA, SPINAL; IMIDAZOLES; ION CHANNEL GATING; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; RATS; RATS, WISTAR;

EID: 77957662526     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.07.010     Document Type: Article

References (46)

1. Agullo G., Gamet-Payrastre L., Manenti S., Viala C., Remesy C., Chap H., Payrastre B. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem. Pharmacol. 1997, 53:1649-1657.
2. Birt D.F., Hendrich S., Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001, 90:157-177.
3. Blackburn-Munro G., Jensen B.S. The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur. J. Pharmacol. 2003, 460:109-116.
4. Calixto J.B., Campos M.M., Otuki M.F., Santos A.R. Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med. 2004, 70:93-103.
5. Calixto J.B., Otuki M.F., Santos A.R. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB). Planta Med. 2003, 69:973-983.
6. Chen Y., Yang L., Lee T.J., Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem. Pharmacol. 2000, 59:1445-1457.
7. Cheng J.K., Ji R.R. Intracellular signaling in primary sensory neurons and persistent pain. Neurochem. Res. 2008, 33:1970-1978.
8. Corzo ., Papp F., Varga Z., Barraza O., Espino-Solis P.G., Rodriguez de la Vega R.C., Gaspar R., Panyi G., Possani L.D. selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus. Biochem. Pharmacol. 2008, 76:1142-1154.
9. Dost R., Rostock A., Rundfeldt C. The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation. Naunyn Schmiedebergs Arch. Pharmacol. 2004, 369:382-390.
10. Edenharder R., Grunhage D. Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutat. Res. 2003, 540:1-18.
11. Everill B., Kocsis J.D. Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy. J. Neurophysiol. 1999, 82:700-708.
12. Ferreira A.C., Neto J.C., da Silva A.C., Kuster R.M., Carvalho D.P. Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids. Chem. Res. Toxicol. 2006, 19:351-355.
13. Gamet-Payrastre L., Manenti S., Gratacap M.P., Tulliez J., Chap H., Payrastre B. Flavonoids and the inhibition of PKC and PI 3-kinase. Gen. Pharmacol. 1999, 32:279-286.
14. Hagenacker T., Splettstoesser F., Greffrath W., Treede R.D., Busselberg D. Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats. Brain Res. 2005, 1062:74-85.
15. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 2002, 96:67-202.
16. Hudmon A., Choi J.S., Tyrrell L., Black J.A., Rush A.M., Waxman S.G., Dib-Hajj S.D. Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons. J. Neurosci. 2008, 28:3190-3201.
17. Ishikawa K., Tanaka M., Black J.A., Waxman S.G. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy. Muscle Nerve 1999, 22:502-507.
18. Ji R.R., Samad T.A., Jin S.X., Schmoll R., Woolf C.J. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002, 36:57-68.
19. Jin X., Gereau R.W.T. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. J. Neurosci. 2006, 26:246-255.
20. Kaczorowski G.J., Garcia M.L. Pharmacology of voltage-gated and calcium-activated potassium channels. Curr. Opin. Chem. Biol. 1999, 3:448-458.
21. Kumamoto T., Fujii M., Hou D.X. Akt is a direct target for myricetin to inhibit cell transformation. Mol. Cell. Biochem. 2009.
22. Mathie A., Wooltorton J.R., Watkins C.S. Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen. Pharmacol. 1998, 30:13-24.
23. 2+ channels. Eur. J. Pharmacol. 2007, 567:198-205.
24. Meotti F.C., Luiz A.P., Pizzolatti M.G., Kassuya C.A., Calixto J.B., Santos A.R. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the l-arginine-nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther. 2006, 316:789-796.
25. Meotti F.C., Missau F.C., Ferreira J., Pizzolatti M.G., Mizuzaki C., Nogueira C.W., Santos A.R. Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice. Biochem. Pharmacol. 2006, 72:1707-1713.
26. Meotti F.C., Posser T., Missau F.C., Pizzolatti M.G., Leal R.B., Santos A.R. Involvement of p38MAPK on the antinociceptive action of myricitrin in mice. Biochem. Pharmacol. 2007, 74:924-931.
27. Meotti F.C., Senthilmohan R., Harwood D.T., Missau F.C., Pizzolatti M.G., Kettle A.J. Myricitrin as a substrate and inhibitor of myeloperoxidase: implications for the pharmacological effects of flavonoids. Free Radic. Biol. Med. 2008, 44:109-120.
28. 2+ channel expression in neonatal rat cardiomyocytes. Eur. J. Pharmacol. 2009, 609:105-112.
29. Nielsen A.N, Mathiesen C., Blackburn-Munro G. Pharmacological characterisation of acid-induced muscle allodynia in rats. Eur. J. Pharmacol. 2004, 487:93-103.
30. Obata K., Noguchi K. MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci. 2004, 74:2643-2653.
31. Ocana M., Cendan C.M., Cobos E.J., Entrena J.M., Baeyens J.M. Potassium channels and pain: present realities and future opportunities. Eur. J. Pharmacol. 2004, 500:203-219.
32. Ramelet A.A. Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. Angiology 2000, 51:19-23.
33. Redman P.T., Hartnett K.A., Aras M.A., Levitan E.S., Aizenman E. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. J. Physiol. 2009, 587:4393-4404.
34. Redman P.T., Jefferson B.S., Ziegler C.B., Mortensen O.V., Torres G.E., Levitan E.S., Aizenman E. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience 2006, 143:1-6.
35. Schafers M., Geis C., Svensson C.I., Luo Z.D., Sommer C. Selective increase of tumour necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve. Eur. J. Neurosci. 2003, 17:791-804.
36. Schafers M., Svensson C.I., Sommer C., Sorkin L.S. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 2003, 23:2517-2521.
37. Shih Y.W., Wu P.F., Lee Y.C., Shi M.D., Chiang T.A. Myricetin suppresses invasion and migration of human lung adenocarcinoma A549 cells: possible mediation by blocking the ERK signaling pathway. J. Agric. Food Chem. 2009, 57:3490-3499.
38. Siegelin M.D., Gaiser T., Habel A., Siegelin Y. Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. Cancer Lett. 2009.
39. Suter M.R., Wen Y.R., Decosterd I., Ji R.R. Do glial cells control pain?. Neuron Glia Biol. 2007, 3:255-268.
40. Svensson C.I., Fitzsimmons B., Azizi S., Powell H.C., Hua X.Y., Yaksh T.L. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J. Neurochem. 2005, 92:1508-1520.
41. Teos L.Y., Zhao A., Alvin Z., Laurence G.G., Li C., Haddad G.E. Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 2008, 295:H1834-1845.
42. Valerio D.A., Georgetti S.R., Magro D.A., Casagrande R., Cunha T.M., Vicentini F.T., Vieira S.M., Fonseca M.J., Ferreira S.H., Cunha F.Q., Verri W.A. Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production. J. Nat. Prod. 2009, 72:1975-1979.
43. Wilk-Blaszczak M.A., Stein B., Xu S., Barbosa M.S., Cobb M.H., Belardetti F. The mitogen-activated protein kinase p38-2 is necessary for the inhibition of N-type calcium current by bradykinin. J. Neurosci. 1998, 18:112-118.
44. Wittmack E.K., Rush A.M., Hudmon A., Waxman S.G., Dib-Hajj S.D. Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. J. Neurosci. 2005, 25:6621-6630.
45. Wray D. The roles of intracellular regions in the activation of voltage-dependent potassium channels. Eur. Biophys. J. 2004, 33:194-200.
46. Wu J., Ding W.G., Matsuura H., Tsuji K., Zang W.J., Horie M. Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. Br. J. Pharmacol. 2009, 156:377-387.