The anti-hyperalgesic activfty of retigabine is mediated by KCNQ potassium channel activation

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 369, Issue 4, 2004, Pages 382-390

  Dost, R ^a   Rostock, A ^a   Rundfeldt, C ^a  

^a Elbion AG   (Germany)

Author keywords

Allodynia; Analgesia; Anticonvulsant; Linopirdine; Neuropathic pain; Potassium channel

Indexed keywords

ANALGESIC AGENT; GABAPENTIN; LINOPIRDINE; POTASSIUM CHANNEL KCNQ1; RETIGABINE; TRAMADOL; 4 AMINOBUTYRIC ACID; AMINE; CARBAMIC ACID DERIVATIVE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; INDOLE DERIVATIVE; KCNQ2 PROTEIN, RAT; KCNQ3 PROTEIN, MOUSE; KCNQ3 PROTEIN, RAT; NARCOTIC ANALGESIC AGENT; PHENYLENEDIAMINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; PYRIDINE DERIVATIVE; VOLTAGE GATED POTASSIUM CHANNEL;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; HYPERALGESIA; LATENT PERIOD; MOUSE; NERVE STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PHARMACOLOGICAL BLOCKING; RAT; SPECIES COMPARISON; TACTILE STIMULATION; TAIL FLICK TEST; THERMAL STIMULATION; WITHDRAWAL REFLEX; ACUTE DISEASE; ANIMAL; CHANNEL GATING; COMPARATIVE STUDY; DISEASE MODEL; MALE; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHYSIOLOGY; SPINAL NERVE; STIMULATION; TOUCH; WISTAR RAT;

ACUTE DISEASE; AMINES; ANALGESICS, OPIOID; ANIMALS; CARBAMATES; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; INDOLES; ION CHANNEL GATING; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MALE; MICE; PERIPHERAL NERVOUS SYSTEM DISEASES; PHENYLENEDIAMINES; PHYSICAL STIMULATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; RATS; RATS, WISTAR; SPINAL NERVES; TOUCH; TRAMADOL;

EID: 2142701447     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-004-0881-1     Document Type: Article

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