Receptors for protons or lipid messengers or both?

Journal of Receptors and Signal Transduction

Volumn 26, Issue 5-6, 2006, Pages 599-610

  Seuwen, Klaus ^a   Ludwig, Marie Gabrielle ^a   Wolf, Romain M ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Acidosis; Bone metabolism; Endothelium; Hypoxia; T cell

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 4; LIPID; LYSOPHOSPHATIDYLCHOLINE; OVARIAN CANCER G PROTEIN COUPLED RECEPTOR 1; PROTON; PSYCHOSINE; RECEPTOR; RECEPTOR G2A; SPHINGOSYLPHOSPHORYLCHOLINE; T CELL DEATH ASSOCIATED GENE 8 PROTEIN; UNCLASSIFIED DRUG;

ACIDITY; ACIDOSIS; AGONIST; BONE METABOLISM; CONCENTRATION RESPONSE; CONFERENCE PAPER; ENDOTHELIUM; HUMAN; HYPOXIA; NONHUMAN; PH; PROTEIN FAMILY; RECEPTOR DOWN REGULATION; SECOND MESSENGER; SENSOR; T LYMPHOCYTE;

HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; PROTONS; RECEPTORS, G-PROTEIN-COUPLED; SECOND MESSENGER SYSTEMS;

EID: 33845207031     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1080/10799890600932220     Document Type: Conference Paper

References (38)

1. Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG. Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. Genomics 1995, 30, 84-88.
2. An S, Tsai C, Goetzl EJ. Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. FEBS Lett 1995, 375, 121-124.
3. Xu Y, Casey G. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics 1996, 35, 397-402.
4. Choi JW, Lee SY, Choi Y. Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol 1996, 168, 78-84.
5. Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, Fernal AA, Le Beau MM, Witte ON. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci USA 1998, 95, 12334-12339.
6. Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y, Damron DS. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol 2000, 2, 261-267.
7. Retraction in: Nat Cell Biol 2006, 8, 299.
8. Zhu K, Baudhuin LM, Hong G, Williams FS, Cristina KL, Kabarowski JH, Witte ON, Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. J Biol Chem 2001, 276, 41325-41335.
9. Retraction in: J Biol Chem 2005, 280, 43280.
10. Kabarowski JH, Zhu K, Le LQ, Witte ON, Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science 2001, 293, 702-705.
11. Retraction in: Science 2005, 307, 206.
12. Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. J Cell Biol 2001, 153, 429-434.
13. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Lysophospholipids-receptor revelations. Science 2001, 294, 1875-1878.
14. Chun J, Rosen H. Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Curr Pharm Des 2006, 12, 161-171.
15. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Proton-sensing G-protein-coupled receptors. Nature 2003, 425, 93-98.
16. Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Kuwabara A, Wakamatsu K, Koizumi H, Uede T, Tsujimoto G, Kurose H, Sato T, Harada A, Misawa N, Tomura H, Okajima F. TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem 2004, 279, 45626-45633.
17. Ishii S, Kihara Y, Shimizu T. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J Biol Chem 2005, 280, 9083-9087.
18. Murakami N, Yokomizo T, Okuno T, Shimizu T. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 2004, 279, 42484-42491.
19. Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci USA 2005, 102, 1632-1637.
20. Obinata H, Hattori T, Nakane S, Tatei K, Izumi T. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. J Biol Chem 2005, 280, 40676-40683.
21. Mogi C, Tomura H, Tobo M, Wang JQ, Damirin A, Kon J, Komachi M, Hashimoto K, Sato K, Okajima F. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J Pharmacol Sci 2005, 99, 160-167.
22. Tomura H, Mogi C, Sato K, Okajima F. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 2005, 17, 1466-1476.
23. Im DS. Two ligands for a GPCR, proton vs lysolipid. Acta Pharmacol Sin 2005, 26, 1435-1441.
24. Meyer zu Heringdorf D, Himmel HM, Jakobs KH. Sphingosylphosphorylcholine- biological functions and mechanisms of action. Biochim Biophys Acta 2002, 1582, 178-189.
25. Alewijnse AE, Michel MC. Sphingosine-1-phosphate and sphingosylphosphorylcholine: Two of a kind? Br J Pharmacol 2006, 147, 347-348.
26. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 2006, 3, 167-175.
27. Komarova SV, Pereverzev A, Shum JW, Sims SM, Dixon SJ. Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc Natl Acad Sci USA 2005, 102, 2643-2648.
28. 2 production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells. J Biol Chem 2005, 280, 34458-34464.
29. Arnett T. Regulation of bone cell function by acid-base balance. Proc Nutr Soc 2003, 62, 511-520.
30. Frick KK, Bushinsky DA. Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. J Bone Miner Res 2003, 18, 1317-1325.
31. Brandao-Burch A, Utting JC, Orriss IR, Arnett TR. Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization. Calcif Tissue Int 2005, 77, 167-174.
32. Aalkjaer C, Peng HL. pH and smooth muscle. Acta Physiol Scand 1997, 161, 557-66.
33. Wray S, Smith RD. Mechanisms of action of pH-induced effects on vascular smooth muscle. Mol Cell Biochem 2004, 263, 163-72.
34. Lum H, Qiao J, Walter RJ, Huang F, Subbaiah PV, Kim KS, Holian O. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol Heart Circ Physiol 2003, 285, H1786-H1789.
35. Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL, Lum H, Anand-Apte B, Xu Y. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J 2005, 19, 819-821.
36. Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Mol Cell Biol 2006, 26, 668-677.
37. Nattie E, Li A. Central chemoreception 2005: A brief review. Auton Neurosci 2006, 126, 332-338.
38. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 1997, 386, 173-177.