Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells

European Journal of Pharmacology

Volumn 605, Issue 1-3, 2009, Pages 15-22

  Iwata, Susumu ^a   Ito, Satoru ^a   Iwaki, Mai ^a   Kondo, Masashi ^a   Sashio, Toyokazu ^a   Takeda, Naoya ^a   Sokabe, Masahiro ^a,b,c   Hasegawa, Yoshinori ^a   Kume, Hiroaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Airway smooth muscle; Asthma; Bronchial smooth muscle; Calcium channel; Cytokine; Fura 2

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM ION; CYTOKINE; EGTAZIC ACID; ENDOTHELIN 1; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NIFEDIPINE; STRESS ACTIVATED PROTEIN KINASE; UO 126;

ARTICLE; ASTHMA; BRONCHUS MUSCLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; UPREGULATION;

CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; HUMANS; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 60349129192     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.045     Document Type: Article

References (46)

1. q-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells. Mol. Pharmacol. 58 (2000) 946-953
2. Ammit A.J., Hastie A.T., Edsall L.C., Hoffman R.K., Amrani Y., Krymskaya V.P., Kane S.A., Peters S.P., Penn R.B., Spiegel S., and Panettieri Jr. R.A. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J. 15 (2001) 1212-1214
3. Ammit A.J., Lazaar A.L., Irani C., O'Neill G.M., Gordon N.D., Amrani Y., Penn R.B., and Panettieri Jr. R.A. Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and β-agonist. Am. J. Respir. Cell Mol. Biol. 26 (2002) 465-474
4. Ammit A.J., Moir L.M., Oliver B.G., Hughes J.M., Alkhouri H., Ge Q., Burgess J.K., Black J.L., and Roth M. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 (2007) L199-L206
5. Amrani Y., and Panettieri Jr. R.A. Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma. Curr. Opin. Allergy Clin. Immunol. 2 (2002) 39-45
6. Amrani Y., Ammit A.J., and Panettieri Jr. R.A. Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-α-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases. Mol. Pharmacol. 60 (2001) 646-655
7. Broide D.H., Lotz M., Cuomo A.J., Coburn D.A., Federman E.C., and Wasserman S.I. Cytokines in symptomatic asthma airways. J. Allergy Clin. Immunol. 89 (1992) 958-967
8. Burgess J.K., Oliver B.G., Poniris M.H., Ge Q., Boustany S., Cox N., Moir L.M., Johnson P.R., and Black J.L. A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. J. Allergy Clin. Immunol. 118 (2006) 649-657
9. Chalmers G.W., Little S.A., Patel K.R., and Thomson N.C. Endothelin-1-induced bronchoconstriction in asthma. Am. J. Respir. Crit. Care Med. 156 (1997) 382-388
10. Chin D., and Means A.R. Calmodulin: a prototypical calcium sensor. Trends Cell Biol. 10 (2000) 322-328
11. Corteling R.L., Li S., Giddings J., Westwick J., Poll C., and Hall I.P. Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. Am. J. Respir. Cell Mol. Biol. 30 (2004) 145-154
12. Elias J.A., Zhu Z., Chupp G., and Homer R.J. Airway remodeling in asthma. J. Clin. Invest. 104 (1999) 985-999
13. Goldie R.G., Henry P.J., Knott P.G., Self G.J., Luttmann M.A., and Hay D.W.P. Endothelin-1 receptor density, distribution and function in human isolated asthmatic airways. Am. J. Respir. Crit. Care Med. 152 (1995) 1653-1658
14. He L.P., Hawavitharana T., Soboloff J., Spassova M.A., and Gill D.L. A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J. Biol. Chem. 280 (2005) 10997-11006
15. Hedges J.C., Singer C.A., and Gerthoffer W.T. Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes. Am. J. Respir. Cell Mol. Biol. 23 (2000) 86-94
16. Huang C.D., Tliba O., Panettieri Jr. R.A., and Amrani Y. Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am. J. Respir. Cell Mol. Biol. 28 (2003) 330-338
17. Huang C.D., Ammit A.J., Tliba O., Kuo H.P., Penn R.B., Panettieri Jr. R.A., and Amrani Y. G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-α-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. J. Biomed. Sci. 12 (2005) 763-776
18. 2+ influx and IL-2 production in T lymphocytes. J. Immunol. 170 (2003) 4441-4449
19. 2+ concentration in guinea pig trachealis. Eur. J. Pharmacol. 486 (2004) 325-333
20. 2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 38 (2008) 407-413
21. 2+ entry by Rho-kinase in tracheal smooth muscle. Am. J. Respir. Cell Mol. Biol. 26 (2002) 491-498
22. Johnson S.R., and Knox A.J. Synthetic functions of airway smooth muscle in asthma. Trends Pharmacol. Sci. 18 (1997) 288-292
23. Konishi M., Olson A., Hollingworth S., and Baylor S.M. Myoplasmic binding of fura-2 investigated by steady-state fluorescence and absorbance measurements. Biophys. J. 54 (1988) 1089-1104
24. Kume H., Takeda N., Oguma T., Ito S., Kondo M., Ito Y., and Shimokata K. Sphingosine 1-phosphate causes airway hyper-reactivity by Rho-mediated myosin phosphatase inactivation. J. Pharmacol. Exp. Ther. 320 (2007) 766-773
25. Lewis R.S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19 (2001) 497-521
26. Mattoli S., Soloperto M., Maurini M., and Fasoli A. Levels of endothelin-1 in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J. Allergy Clin. Immunol. 88 (1991) 376-384
27. 2+ signaling by endothelin receptors in rat and human cultured airway smooth muscle cells. Br. J. Pharmacol. 125 (1998) 1768-1778
28. McKay S., Hirst S.J., Bertrand-de Haas M., de Jongste J.C., Hoogsteden H.C., Saxena P.R., and Sharma H.S. Tumor necrosis factor-α enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 23 (2000) 103-111
29. McWhinnie R., Pechkovsky D.V., Zhou D., Lane D., Halayko A.J., Knight D.A., and Bai T.R. Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 (2007) L278-L286
30. Michael J., and Markewitz B. Endothelins and the lung. Am. J. Respir. Crit. Care Med. 154 (1996) 555-581
31. Murray R.K., and Kotlikoff M.I. Receptor-activated calcium influx in human airway smooth muscle cells. J. Physiol. 435 (1991) 123-144
32. Oonuma H., Nakajima T., Nagata T., Iwasawa K., Wang Y., Hazama H., Morita Y., Wang Y., Yamamoto K., Nagai R., and Omata M. Endothelin-1 is a potent activator of nonselective cation currents in human bronchial smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 23 (2000) 213-221
33. Panettieri Jr. R.A., Goldie R.G., Rigby P.J., Eszterhas A.J., and Hay D.W. Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon. Br. J. Pharmacol. 118 (1996) 191-197
34. Peel S.E., Liu B., and Hall I.P. A key role for STIM1 in store operated calcium channel activation in airway smooth muscle. Respir. Res. 7 (2006) 119
35. Pegorier S., Arouche N., Dombret M.C., Aubier M., and Pretolani M. Augmented epithelial endothelin-1 expression in refractory asthma. J. Allergy Clin. Immunol. 120 (2007) 1301-1307
36. 2+ sensitization. Am. J. Physiol. Lung Cell. Mol. Physiol. 293 (2007) L1000-L1111
37. Perez-Zoghbi, J.F., Karner, C., Ito, S., Alrashdan, Y.A., Shepherd, M., Sanderson, M., in press. Ion channel regulation of intracellular calcium and airway smooth muscle function. Pulm. Pharmacol. Ther. doi:10.1016/j.pupt.2008.09.006.
38. Pollock D.M., Keith T.L., and Highsmith R.F. Endothelin receptors and calcium signaling. FASEB J. 9 (1995) 1196-1204
39. Redington A.E., Springall D.R., Ghatei M.A., Lau L.C., Bloom S.R., Holgate S.T., Polak J.M., and Howarth P.H. Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am. J. Respir. Crit. Care Med. 151 (1995) 1034-1039
40. Rubanyi G.M., and Polokoff M.A. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46 (1994) 325-415
41. Schaafsma D., Gosens R., Zaagsma J., Halayko A.J., and Meurs H. Rho kinase inhibitors: a novel therapeutical intervention in asthma? Eur, J. Pharmacol. 585 (2008) 398-406
42. 2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells. Biochem. Biophys. Res. Commun. 359 (2007) 747-751
43. Takeda N., Kondo M., Ito S., Ito Y., Shimokata K., and Kume H. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am. J. Respir. Cell Mol. Biol. 35 (2006) 722-729
44. 2+-dependent mechanisms. Am. J. Physiol. Cell Physiol. 293 (2007) C1139-C1147
45. Yadav M., Clark L., and Schorey J.S. Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase. J. Immunol. 176 (2006) 5494-5503
46. 2+ sensitization. Am. J. Respir. Cell Mol. Biol. 20 (1999) 1190-1200