Dynamic control of yeast MAP kinase network by induced association and dissociation between the ste50 scaffold and the Opy2 membrane anchor

Molecular Cell

Volumn 40, Issue 1, 2010, Pages 87-98

  Yamamoto, Katsuyoshi ^a   Tatebayashi, Kazuo ^a   Tanaka, Keiichiro ^a   Saito, Haruo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN FUS3; PROTEIN HOG1; PROTEIN KSS1; PROTEIN OPY2; PROTEIN STE11; PROTEIN STE50; PROTEIN YCK1; PROTIN YCK2; UNCLASSIFIED DRUG; CASEIN KINASE I; FUS3 PROTEIN, S CEREVISIAE; HOG1 PROTEIN, S CEREVISIAE; KSS1 PROTEIN, S CEREVISIAE; OPY2 PROTEIN, S CEREVISIAE; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN; SHO1 PROTEIN, S CEREVISIAE; STE50 PROTEIN, S CEREVISIAE; YCK1 PROTEIN, S CEREVISIAE; YCK2 PROTEIN, S CEREVISIAE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DISSOCIATION; MOLECULAR DYNAMICS; NONHUMAN; OSMOREGULATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; YEAST; AMINO ACID SEQUENCE; CYTOPLASM; ENZYMOLOGY; FEEDBACK SYSTEM; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; TIME;

AMINO ACID SEQUENCE; BINDING SITES; CASEIN KINASE I; CYTOPLASM; FEEDBACK, PHYSIOLOGICAL; GLUCOSE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS;

EID: 77957360802     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.09.011     Document Type: Article

References (35)

1. Brewster J.L., de Valoir T., Dwyer N.D., Winter E., Gustin M.C. An osmosensing signal transduction pathway in yeast. Science 1993, 259:1760-1763.
2. Chen R.E., Thorner J. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 2007, 1773:1311-1340.
3. Cullen P.J., Sabbagh W., Graham E., Irick M.M., van Olden E.K., Neal C., Delrow J., Bardwell L., Sprague G.F. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev. 2004, 18:1695-1708.
4. Davenport K.D., Williams K.E., Ullmann B.D., Gustin M.C. Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants. Genetics 1999, 153:1091-1103.
5. Doi K., Gartner A., Ammerer G., Errede B., Shinkawa H., Sugimoto K., Matsumoto K. MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J. 1994, 13:61-70.
6. Drogen F., O'Rourke S.M., Stucke V.M., Jaquenoud M., Neiman A.M., Peter M. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr. Biol. 2000, 10:630-639.
7. Ekiel I., Sulea T., Jansen G., Kowalik M., Minailiuc O., Cheng J., Harcus D., Cygler M., Whiteway M., Wu C. Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway. Mol. Biol. Cell 2009, 20:5117-5126.
8. Escoté X., Zapater M., Clotet J., Posas F. Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1. Nat. Cell Biol. 2004, 6:997-1002.
9. Flotow H., Roach P.J. Role of acidic residues as substrate determinants for casein kinase I. J. Biol. Chem. 1991, 266:3724-3727.
10. Hao N., Zeng Y., Elston T.C., Dohlman H.G. Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J. Biol. Chem. 2008, 283:33798-33802.
11. Hohmann S. Osmotic stress signaling and osmoadaptation in yeasts. Microbiol. Mol. Biol. Rev. 2002, 66:300-372.
12. Koshland D.E., Goldbeter A., Stock J.B. Amplification and adaptation in regulatory and sensory systems. Science 1982, 217:220-225.
13. Lamson R.E., Winters M.J., Pryciak P.M. Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20. Mol. Cell. Biol. 2002, 22:2939-2951.
14. Maeda T., Wurgler-Murphy S.M., Saito H. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 1994, 369:242-245.
15. Maeda T., Takekawa M., Saito H. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 1995, 269:554-558.
16. McClean M.N., Mody A., Broach J.R., Ramanathan S. Cross-talk and decision making in MAP kinase pathways. Nat. Genet. 2007, 39:409-414.
17. Miller J.H. Experiments in Molecular Genetics 1972, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. O'Rourke S.M., Herskowitz I. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev. 1998, 12:2874-2886.
19. Pitoniak A., Birkaya B., Dionne H.M., Vadaie N., Cullen P.J. The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol. Biol. Cell 2009, 20:3101-3114.
20. Posas F., Witten E.A., Saito H. Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 1998, 18:5788-5796.
21. Ramezani Rad M., Jansen G., Bühring F., Hollenberg C.P. Ste50p is involved in regulating filamentous growth in the yeast Saccharomyces cerevisiae and associates with Ste11p. Mol. Gen. Genet. 1998, 259:29-38.
22. Shock T.R., Thompson J., Yates J.R., Madhani H.D. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryot. Cell 2009, 8:606-616.
23. Takekawa M., Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 1998, 95:521-530.
24. Tatebayashi K., Takekawa M., Saito H. A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway. EMBO J. 2003, 22:3624-3634.
25. Tatebayashi K., Yamamoto K., Tanaka K., Tomida T., Maruoka T., Kasukawa E., Saito H. Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. EMBO J. 2006, 25:3033-3044.
26. Tatebayashi K., Tanaka K., Yang H.-Y., Yamamoto K., Matsushita Y., Tomida T., Imai M., Saito H. Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J. 2007, 26:3521-3533.
27. Toda T., Uno I., Ishikawa T., Powers S., Kataoka T., Broek D., Cameron S., Broach J., Matsumoto K., Wigler M. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 1985, 40:27-36.
28. Truckses D.M., Bloomekatz J.E., Thorner J. The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 2006, 26:912-928.
29. Wu C., Leberer E., Thomas D.Y., Whiteway M. Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae. Mol. Biol. Cell 1999, 10:2425-2440.
30. Wu C., Jansen G., Zhang J., Thomas D.Y., Whiteway M. Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association. Genes Dev. 2006, 20:734-746.
31. Wurgler-Murphy S.M., Maeda T., Witten E.A., Saito H. Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol. Cell. Biol. 1997, 17:1289-1297.
32. Xu G., Jansen G., Thomas D.Y., Hollenberg C.P., Ramezani Rad M. Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 1996, 20:773-783.
33. Yang H.-Y., Tatebayashi K., Yamamoto K., Saito H. Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK. EMBO J. 2009, 28:1380-1391.
34. Zaman S., Lippman S.I., Zhao X., Broach J.R. How Saccharomyces responds to nutrients. Annu. Rev. Genet. 2008, 42:27-81.
35. Zhan X.-L., Deschenes R.J., Guan K.-L. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev. 1997, 11:1690-1702.