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Volumn 49, Issue 2, 2008, Pages 251-261

Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes

Author keywords

Bile acids; cAMP GEF; Collagen; Exchange protein regulated by cAMP (EPAC); Extracellular matrix; Focal adhesion kinase; JNK; Laminin; Phosphoinositide 3 kinase (PI3K); Polylysine

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BILE ACID; COLLAGEN TYPE 1; CYCLIC AMP; CYTOCHALASIN B; DEOXYCHOLIC ACID; FAS LIGAND; FOCAL ADHESION KINASE; GLYCOCHENODEOXYCHOLIC ACID; GUANINE DERIVATIVE; GUANINE EXCHANGE FACTOR; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHOSPHOSPECIFIC ANTIBODY; POLYLYSINE;

EID: 46149092240     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.04.015     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 0036351423 scopus 로고    scopus 로고
    • Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes
    • Smets F.N., Yongming C., Ling-Jia W., and Soriano H. Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes. Mol Gen Metab 75 (2002) 344-352
    • (2002) Mol Gen Metab , vol.75 , pp. 344-352
    • Smets, F.N.1    Yongming, C.2    Ling-Jia, W.3    Soriano, H.4
  • 2
    • 11144331377 scopus 로고    scopus 로고
    • RGD peptides confer survival to hepatocytes via the b1-integrin-ILK-pAkt pathway
    • Pinkse G.G.M., Jiawan-Lalai R., Bruijn J., and deHeer E. RGD peptides confer survival to hepatocytes via the b1-integrin-ILK-pAkt pathway. J Hepatol 42 (2005) 87-93
    • (2005) J Hepatol , vol.42 , pp. 87-93
    • Pinkse, G.G.M.1    Jiawan-Lalai, R.2    Bruijn, J.3    deHeer, E.4
  • 3
    • 3142704439 scopus 로고    scopus 로고
    • Hepatocyte survival depends on α 1 integrin mediated attachment of hepatocytes to hepatic extracellular matrix
    • Pinske G.G.M., Voorhoeve M.P., Noteborn M., Terpstra O.T., Bruijn J.A., and de Heer E. Hepatocyte survival depends on α 1 integrin mediated attachment of hepatocytes to hepatic extracellular matrix. Liver Inter 24 (2004) 218-226
    • (2004) Liver Inter , vol.24 , pp. 218-226
    • Pinske, G.G.M.1    Voorhoeve, M.P.2    Noteborn, M.3    Terpstra, O.T.4    Bruijn, J.A.5    de Heer, E.6
  • 4
    • 33751328368 scopus 로고    scopus 로고
    • Primary hepatocyte survival on non-integrin recognizable matrices without the activation of Akt
    • Hosiba T., Nagahara H., Cho C.-S., and Tagawa Y-I Akaike T. Primary hepatocyte survival on non-integrin recognizable matrices without the activation of Akt. Biomaterials 28 (2007) 1093-1104
    • (2007) Biomaterials , vol.28 , pp. 1093-1104
    • Hosiba, T.1    Nagahara, H.2    Cho, C.-S.3    Tagawa Y-I Akaike, T.4
  • 5
    • 0032813842 scopus 로고    scopus 로고
    • The effects of cell density, attachment substratum and dexamethasone on spontaneous apoptosis of rat hepatocytes in primary culture
    • Qiao L., and Farrel G. The effects of cell density, attachment substratum and dexamethasone on spontaneous apoptosis of rat hepatocytes in primary culture. In Vitro Cell Dev Biol 35 (1999) 417-424
    • (1999) In Vitro Cell Dev Biol , vol.35 , pp. 417-424
    • Qiao, L.1    Farrel, G.2
  • 6
    • 0021808620 scopus 로고
    • The hepatocellular matrix II: Electron immunohistochemical studies in rats with CCl4 induced cirrhosis
    • Martinez-Hernandez A. The hepatocellular matrix II: Electron immunohistochemical studies in rats with CCl4 induced cirrhosis. Lab Invest 53 (1985) 166-186
    • (1985) Lab Invest , vol.53 , pp. 166-186
    • Martinez-Hernandez, A.1
  • 7
    • 0021131587 scopus 로고
    • The hepatic extracellular matrix I: Electron immunohistochemical studies in normal rat liver
    • Martinez-Hernandez A. The hepatic extracellular matrix I: Electron immunohistochemical studies in normal rat liver. Lab Invest 51 (1984) 57-74
    • (1984) Lab Invest , vol.51 , pp. 57-74
    • Martinez-Hernandez, A.1
  • 8
    • 0041315539 scopus 로고    scopus 로고
    • Divergent patterns of extracellular matrix protein expression in neonatal versus adult liver fibrosis
    • Zeitlin L., Resnick M.S., Konikoff F., Schuppan D., Bujanover Y., Lerner A., et al. Divergent patterns of extracellular matrix protein expression in neonatal versus adult liver fibrosis. Pediatr Pathol Mol Med 22 (2003) 349-362
    • (2003) Pediatr Pathol Mol Med , vol.22 , pp. 349-362
    • Zeitlin, L.1    Resnick, M.S.2    Konikoff, F.3    Schuppan, D.4    Bujanover, Y.5    Lerner, A.6
  • 9
    • 0032955760 scopus 로고    scopus 로고
    • Immunohistochemical study on phenotypical changes of hepatocytes in liver disease with reference to extracellular matrix composition
    • Matsumoto S., Yamamoto K., Nagano T., Okamoto R., Ibuki N., Tagashira M., et al. Immunohistochemical study on phenotypical changes of hepatocytes in liver disease with reference to extracellular matrix composition. Liver 19 (1999) 32-38
    • (1999) Liver , vol.19 , pp. 32-38
    • Matsumoto, S.1    Yamamoto, K.2    Nagano, T.3    Okamoto, R.4    Ibuki, N.5    Tagashira, M.6
  • 10
    • 0030947446 scopus 로고    scopus 로고
    • Extracellular matrix deposition, lysyl oxidase expression and myofibroplastic differentiation during the initial stages of cholestatic fibrosis in the rat
    • Desmouliere A., Darby I., Costa A.M., Raccurt M., Tuchweber B., Sommer P., et al. Extracellular matrix deposition, lysyl oxidase expression and myofibroplastic differentiation during the initial stages of cholestatic fibrosis in the rat. Lab Invest 76 (1997) 765-778
    • (1997) Lab Invest , vol.76 , pp. 765-778
    • Desmouliere, A.1    Darby, I.2    Costa, A.M.3    Raccurt, M.4    Tuchweber, B.5    Sommer, P.6
  • 11
    • 0025908978 scopus 로고
    • Distribution of the VLA family of integrins in normal and pathologic liver tissue
    • Volpes R., van den Oord J.J., and Desmet V.J. Distribution of the VLA family of integrins in normal and pathologic liver tissue. Gastroenterology 101 (1991) 200-206
    • (1991) Gastroenterology , vol.101 , pp. 200-206
    • Volpes, R.1    van den Oord, J.J.2    Desmet, V.J.3
  • 12
    • 35648978998 scopus 로고    scopus 로고
    • Structure and mechanics of integrin-based cell adhesion
    • Arnaout M.A., Goodman S.L., and Xiong J.P. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 19 (2007) 495-507
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 495-507
    • Arnaout, M.A.1    Goodman, S.L.2    Xiong, J.P.3
  • 13
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-src signaling in normal and cancer cells
    • Mitra S.K., and Schlaepfer D.D. Integrin-regulated FAK-src signaling in normal and cancer cells. Curr Opin Cell Biol 18 (2006) 516-523
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 14
    • 33846554255 scopus 로고    scopus 로고
    • Focal adhesion kinase: a potential target in cancer therapy
    • van Nimwegen M.J., and van de Water B. Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol 73 (2007) 597-609
    • (2007) Biochem Pharmacol , vol.73 , pp. 597-609
    • van Nimwegen, M.J.1    van de Water, B.2
  • 16
    • 0034836545 scopus 로고    scopus 로고
    • Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor a/cycloheximide induced apoptosis by regulating protein kinase B levels
    • Fang Y., Wang L., Jin J., and Zha X. Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor a/cycloheximide induced apoptosis by regulating protein kinase B levels. Eur J Biochem 268 (2001) 4513-4519
    • (2001) Eur J Biochem , vol.268 , pp. 4513-4519
    • Fang, Y.1    Wang, L.2    Jin, J.3    Zha, X.4
  • 17
    • 0037404039 scopus 로고    scopus 로고
    • Bile acid regulation of hepatic physiology IV: Bile acids and death receptors
    • Higuchi H., and Gores G.J. Bile acid regulation of hepatic physiology IV: Bile acids and death receptors. Am J Physiol Gastrointest Liver Physiol 284 (2003) G734-G738
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Higuchi, H.1    Gores, G.J.2
  • 18
    • 10744225137 scopus 로고    scopus 로고
    • Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
    • Schoemaker M.H., Gommans W.M., Conde de la Rosa L., Homan M., Klok P., Trautwein C., et al. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol 39 (2003) 153-161
    • (2003) J Hepatol , vol.39 , pp. 153-161
    • Schoemaker, M.H.1    Gommans, W.M.2    Conde de la Rosa, L.3    Homan, M.4    Klok, P.5    Trautwein, C.6
  • 19
    • 33847404606 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines
    • Mitchell C., Park M.A., Zhang G., Han S.I., Harada H., Franklin R.A., et al. 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. Mol Cancer Ther 6 (2007) 618-632
    • (2007) Mol Cancer Ther , vol.6 , pp. 618-632
    • Mitchell, C.1    Park, M.A.2    Zhang, G.3    Han, S.I.4    Harada, H.5    Franklin, R.A.6
  • 20
    • 0038373452 scopus 로고    scopus 로고
    • cFLIP-L inhibits p38 MAPK activation: an additional anti-apoptotic mechanism in bile acid-mediated apoptosis
    • Grambihler A., Higuchi H., Bronk S.F., and Gores G.J. cFLIP-L inhibits p38 MAPK activation: an additional anti-apoptotic mechanism in bile acid-mediated apoptosis. J Biol Chem 278 (2001) 26831-26837
    • (2001) J Biol Chem , vol.278 , pp. 26831-26837
    • Grambihler, A.1    Higuchi, H.2    Bronk, S.F.3    Gores, G.J.4
  • 21
    • 3042594002 scopus 로고    scopus 로고
    • Involvement of integrins and Src in tauroursodeoxycholate induced and swelling induced choleresis
    • Haussinger D., Kurz A.K., Wettstein M., Graf D., Vom Dahl S., and Schliess F. Involvement of integrins and Src in tauroursodeoxycholate induced and swelling induced choleresis. Gastroenterology 124 (2003) 1476-1487
    • (2003) Gastroenterology , vol.124 , pp. 1476-1487
    • Haussinger, D.1    Kurz, A.K.2    Wettstein, M.3    Graf, D.4    Vom Dahl, S.5    Schliess, F.6
  • 22
    • 33845390777 scopus 로고    scopus 로고
    • Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2
    • Khare S., Holgren C., and Samarel A.M. Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. Am J Physiol Gastrointest Liver Physiol 291 (2006) G1100-G1112
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Khare, S.1    Holgren, C.2    Samarel, A.M.3
  • 23
    • 0036721290 scopus 로고    scopus 로고
    • cAMP inhibits bile acid induced apoptosis by blocking caspase activation and cytochrome C release
    • Webster C.R.L., Usechek P., and Anwer M.S. cAMP inhibits bile acid induced apoptosis by blocking caspase activation and cytochrome C release. Am J Physiol Gastrointest Liver Physiol 283 (2002) G727-G738
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Webster, C.R.L.1    Usechek, P.2    Anwer, M.S.3
  • 24
    • 0038172651 scopus 로고    scopus 로고
    • Inhibition of taurolithocholate 3-sulfate induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and independent mechanisms
    • Graf D., Reinehr R., Kurz A.K., Fischer R., and Haussinger D. Inhibition of taurolithocholate 3-sulfate induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and independent mechanisms. Arch Biochem Biophys 425 (2003) 34-42
    • (2003) Arch Biochem Biophys , vol.425 , pp. 34-42
    • Graf, D.1    Reinehr, R.2    Kurz, A.K.3    Fischer, R.4    Haussinger, D.5
  • 25
    • 3242656381 scopus 로고    scopus 로고
    • Activation of cAMP-guanine exchange factor (cAMP-GEF) confers protein kinase A independent protection from hepatocyte apoptosis
    • Cullen K., McCool J., Anwer M.S., and Webster C.R.L. Activation of cAMP-guanine exchange factor (cAMP-GEF) confers protein kinase A independent protection from hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol 287 (2004) G334-G343
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Cullen, K.1    McCool, J.2    Anwer, M.S.3    Webster, C.R.L.4
  • 26
    • 33751241720 scopus 로고    scopus 로고
    • Epac proteins: multi-purpose cAMP targets
    • Bos J.L. Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 31 (2006) 680-686
    • (2006) Trends Biochem Sci , vol.31 , pp. 680-686
    • Bos, J.L.1
  • 28
    • 0028076807 scopus 로고
    • Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth
    • Hansen L., Mooney D., Vacanti J., and Ingber D. Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Chem 5 (1994) 967-975
    • (1994) Mol Biol Chem , vol.5 , pp. 967-975
    • Hansen, L.1    Mooney, D.2    Vacanti, J.3    Ingber, D.4
  • 29
    • 2442662132 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
    • Schoemaker M.H., Conde de la Rosa L., Buist-Homan M., Vrenken T.E., Havinga R., Poelstra K., et al. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 39 (2004) 1563-1573
    • (2004) Hepatology , vol.39 , pp. 1563-1573
    • Schoemaker, M.H.1    Conde de la Rosa, L.2    Buist-Homan, M.3    Vrenken, T.E.4    Havinga, R.5    Poelstra, K.6
  • 31
    • 0022618197 scopus 로고
    • Interactions of rat hepatocytes with type IV collagen, fibronectin and laminin matrices
    • Bissell D.M., Stamatoglou S.C., Nermut M.V., and Hughes C. Interactions of rat hepatocytes with type IV collagen, fibronectin and laminin matrices. Eur J Cell Biol 40 (1986) 72-78
    • (1986) Eur J Cell Biol , vol.40 , pp. 72-78
    • Bissell, D.M.1    Stamatoglou, S.C.2    Nermut, M.V.3    Hughes, C.4
  • 33
    • 34547993706 scopus 로고    scopus 로고
    • Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways
    • Bouchard V., Demers M.J., Thibodeau S., Laquerre V., Fujita N., Tsuruo T., et al. Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol 212 (2007) 717-728
    • (2007) J Cell Physiol , vol.212 , pp. 717-728
    • Bouchard, V.1    Demers, M.J.2    Thibodeau, S.3    Laquerre, V.4    Fujita, N.5    Tsuruo, T.6
  • 34
    • 9144242920 scopus 로고    scopus 로고
    • Human intestinal epithelial crypt cell survival and death: complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways
    • Harnois C., Demers M.J., Bouchard V., Vallee K., Gagne D., Fujita N., et al. Human intestinal epithelial crypt cell survival and death: complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol 198 (2004) 209-222
    • (2004) J Cell Physiol , vol.198 , pp. 209-222
    • Harnois, C.1    Demers, M.J.2    Bouchard, V.3    Vallee, K.4    Gagne, D.5    Fujita, N.6
  • 35
    • 0034711221 scopus 로고    scopus 로고
    • Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK
    • Barberis L., Wary K.K., Fiucci G., Liu F., Hirsch F., Brancaccio M., et al. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275 (2000) 36532-36540
    • (2000) J Biol Chem , vol.275 , pp. 36532-36540
    • Barberis, L.1    Wary, K.K.2    Fiucci, G.3    Liu, F.4    Hirsch, F.5    Brancaccio, M.6
  • 36
    • 33750474132 scopus 로고    scopus 로고
    • Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes
    • Hirano F., Haneda M., and Makino I. Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes. J Gastroenterol Hepatol 21 (2006) 1807-1813
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 1807-1813
    • Hirano, F.1    Haneda, M.2    Makino, I.3
  • 37
    • 22144479683 scopus 로고    scopus 로고
    • The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study
    • Wu Y., Nan L., Bardag-Gorce F., Li J., French B.A., Wilson L.T., et al. The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study. Exp Mol Pathol 79 (2005) 1-8
    • (2005) Exp Mol Pathol , vol.79 , pp. 1-8
    • Wu, Y.1    Nan, L.2    Bardag-Gorce, F.3    Li, J.4    French, B.A.5    Wilson, L.T.6
  • 38
    • 3442890219 scopus 로고    scopus 로고
    • Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor
    • Fujii T., Koshikawa K., Nomoto S., Okochi O., Kaneko T., Inoue S., et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol 41 (2004) 104-111
    • (2004) J Hepatol , vol.41 , pp. 104-111
    • Fujii, T.1    Koshikawa, K.2    Nomoto, S.3    Okochi, O.4    Kaneko, T.5    Inoue, S.6
  • 39
  • 42
    • 0027788161 scopus 로고
    • Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated hepatocyte couplets
    • Thibault N., Maurice M., Maratrat M., Cordier A., Feldman G., and Ballet F. Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated hepatocyte couplets. J Hepatol 19 (1993) 367-376
    • (1993) J Hepatol , vol.19 , pp. 367-376
    • Thibault, N.1    Maurice, M.2    Maratrat, M.3    Cordier, A.4    Feldman, G.5    Ballet, F.6
  • 43
    • 34249798185 scopus 로고    scopus 로고
    • FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway
    • Thamilselvan V., Craig D.H., and Basson M.D. FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 21 (2007) 1730-1741
    • (2007) FASEB J , vol.21 , pp. 1730-1741
    • Thamilselvan, V.1    Craig, D.H.2    Basson, M.D.3
  • 44
    • 12344334474 scopus 로고    scopus 로고
    • Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells
    • Montiel M., de la Blanca E.P., and Jimenez E. Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochem Biophys Res Commun 25;327 (2005) 971-978
    • (2005) Biochem Biophys Res Commun , vol.25 327 , pp. 971-978
    • Montiel, M.1    de la Blanca, E.P.2    Jimenez, E.3
  • 45
    • 36348941176 scopus 로고    scopus 로고
    • p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis
    • Amaral J.D., Castro R.E., Solá S., Steer C.J., and Rodrigues C.M. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. J Biol Chem 282 (2007) 34250-34259
    • (2007) J Biol Chem , vol.282 , pp. 34250-34259
    • Amaral, J.D.1    Castro, R.E.2    Solá, S.3    Steer, C.J.4    Rodrigues, C.M.5
  • 47
    • 0036679895 scopus 로고    scopus 로고
    • Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications
    • Shaker A.M. Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications. Curr Opin Chem Biol 6 (2002) 534-554
    • (2002) Curr Opin Chem Biol , vol.6 , pp. 534-554
    • Shaker, A.M.1
  • 48
    • 0142026204 scopus 로고    scopus 로고
    • Therapeutic antagonists and conformational regulation of integrin function
    • Shimaoka M., and Springer T.A. Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov 2 (2003) 703-716
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 703-716
    • Shimaoka, M.1    Springer, T.A.2
  • 49
    • 34248593729 scopus 로고    scopus 로고
    • Antisense integrin alphaV and beta3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas
    • Li J., Tan H., Dong X., Xu Z., Shi C., Han X., et al. Antisense integrin alphaV and beta3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas. Dig Liver Dis 39 (2007) 557-565
    • (2007) Dig Liver Dis , vol.39 , pp. 557-565
    • Li, J.1    Tan, H.2    Dong, X.3    Xu, Z.4    Shi, C.5    Han, X.6
  • 50
    • 34047117772 scopus 로고    scopus 로고
    • Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro
    • Patsenker E., Popov Y., Wiesner M., Goodman S.L., and Schuppan D. Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro. J Hepatol 46 (2007) 878-887
    • (2007) J Hepatol , vol.46 , pp. 878-887
    • Patsenker, E.1    Popov, Y.2    Wiesner, M.3    Goodman, S.L.4    Schuppan, D.5
  • 51
    • 34250163937 scopus 로고    scopus 로고
    • Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, et. al. A novel low molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth Mol Carcinog 2007;46: 488-496.
    • Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, et. al. A novel low molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth Mol Carcinog 2007;46: 488-496.


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