메뉴 건너뛰기




Volumn 137, Issue 8, 2010, Pages 1213-1225

Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice

Author keywords

hepatic stellate cell; IL 13; liver fibrosis; paeoniflorin; schistosomiasis; STAT6; suppressor of cytokine signalling 1

Indexed keywords

COLLAGEN; HYDROXYPROLINE; INTERLEUKIN 13; PAEONIFLORIN; UNCLASSIFIED DRUG; ZL 080410; BENZOIC ACID DERIVATIVE; BRIDGED COMPOUND; GLUCOSIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 77957326602     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S003118201000003X     Document Type: Article
Times cited : (31)

References (59)
  • 2
    • 33746310348 scopus 로고    scopus 로고
    • A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis
    • Bartley, P. B., Ramm, G. A., Jones, M. K., Ruddell, R. G., Li, Y. and Mcmanus, D. P. (2006). A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis. International Journal for Parasitology 36, 993-1001.
    • (2006) International Journal for Parasitology , vol.36 , pp. 993-1001
    • Bartley, P.B.1    Ramm, G.A.2    Jones, M.K.3    Ruddell, R.G.4    Li, Y.5    Mcmanus, D.P.6
  • 3
    • 31344441408 scopus 로고    scopus 로고
    • The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model
    • Chan, K., Liu, Z. Q., Jiang, Z. H., Zhou, H., Wong, Y. F., Xu, H. X. and Liu, L. (2006). The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. Journal of Ethnopharmacology 103, 425-432.
    • (2006) Journal of Ethnopharmacology , vol.103 , pp. 425-432
    • Chan, K.1    Liu, Z.Q.2    Jiang, Z.H.3    Zhou, H.4    Wong, Y.F.5    Xu, H.X.6    Liu, L.7
  • 4
    • 33644504204 scopus 로고    scopus 로고
    • Hepatic stellate cells in human schistosomiasis mansoni: A comparative immunohistochemical study with liver cirrhosis
    • Chang, D., Ramalho, L. N., Ramalho, F. S., Martinelli, A. L. and Zucoloto, S. (2006). Hepatic stellate cells in human schistosomiasis mansoni: a comparative immunohistochemical study with liver cirrhosis. Acta Tropica 97, 318-323.
    • (2006) Acta Tropica , vol.97 , pp. 318-323
    • Chang, D.1    Ramalho, L.N.2    Ramalho, F.S.3    Martinelli, A.L.4    Zucoloto, S.5
  • 5
    • 0036864074 scopus 로고    scopus 로고
    • Dynamic changes in the collagen metabolism of liver fibrosis at the transcription level in rabbits with Schistosomiasis japonica
    • Chen, F., Cai, W., Chen, Z., Chen, X. and Liu, R. (2002). Dynamic changes in the collagen metabolism of liver fibrosis at the transcription level in rabbits with Schistosomiasis japonica. Chinese Medicine Journal (English) 115, 1637-1640.
    • (2002) Chinese Medicine Journal (English) , vol.115 , pp. 1637-1640
    • Chen, F.1    Cai, W.2    Chen, Z.3    Chen, X.4    Liu, R.5
  • 6
    • 0034923170 scopus 로고    scopus 로고
    • Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    • Chiaramonte, M. G., Cheever, A. W., Malley, J. D., Donaldson, D. D. and Wynn, T. A. (2001). Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34, 273-282.
    • (2001) Hepatology , vol.34 , pp. 273-282
    • Chiaramonte, M.G.1    Cheever, A.W.2    Malley, J.D.3    Donaldson, D.D.4    Wynn, T.A.5
  • 7
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W. and Wynn, T. A. (1999a). An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. Journal of Clinical Investigation, 104, 777-785.
    • (1999) Journal of Clinical Investigation , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 9
    • 0033555809 scopus 로고    scopus 로고
    • IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
    • Chiaramonte, M. G., Schopf, L. R., Neben, T. Y., Cheever, A. W., Donaldson, D. D. and Wynn, T. A. (1999b). IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. Journal of Immunology 162, 920-930.
    • (1999) Journal of Immunology , vol.162 , pp. 920-930
    • Chiaramonte, M.G.1    Schopf, L.R.2    Neben, T.Y.3    Cheever, A.W.4    Donaldson, D.D.5    Wynn, T.A.6
  • 10
    • 36648998997 scopus 로고    scopus 로고
    • Paeoniflorin inhibits TGF-beta1-mediated collagen production by Schistosoma japonicum soluble egg antigen in vitro
    • Chu, D., Luo, Q., Li, C., Gao, Y., Yu, L., Wei, W., Wu, Q. and Shen, J. (2007). Paeoniflorin inhibits TGF-beta1-mediated collagen production by Schistosoma japonicum soluble egg antigen in vitro. Parasitology 134, 1611-1621.
    • (2007) Parasitology , vol.134 , pp. 1611-1621
    • Chu, D.1    Luo, Q.2    Li, C.3    Gao, Y.4    Yu, L.5    Wei, W.6    Wu, Q.7    Shen, J.8
  • 15
    • 0031831851 scopus 로고    scopus 로고
    • Isolation and culture of rat hepatic stellate cells
    • Ga., R. (1998). Isolation and culture of rat hepatic stellate cells. Journal of Gastroenterology and Hepatology 13, 846-851.
    • (1998) Journal of Gastroenterology and Hepatology , vol.13 , pp. 846-851
    • Ga, R.1
  • 16
    • 34548142644 scopus 로고    scopus 로고
    • Interleukin 13 and interleukin 13 receptor involvement in systemic sclerosis
    • Granel, B., Chevillard, C. and Dessein, A. (2007). [Interleukin 13 and interleukin 13 receptor involvement in systemic sclerosis]. Revue de Medicne Interne 28, 613-622.
    • (2007) Revue de Medicne Interne , vol.28 , pp. 613-622
    • Granel, B.1    Chevillard, C.2    Dessein, A.3
  • 17
    • 24144487722 scopus 로고    scopus 로고
    • Schistosomiasis: Implications for world travelers and healthcare providers
    • quiz 206-207
    • Greenwald, B. (2005). Schistosomiasis: implications for world travelers and healthcare providers. Gastroenterology Nursing 28, 203-205; quiz 206-207.
    • (2005) Gastroenterology Nursing , vol.28 , pp. 203-205
    • Greenwald, B.1
  • 18
    • 0031819504 scopus 로고    scopus 로고
    • The cell biology of liver fibrogenesis - An imbalance of proliferation, growth arrest and apoptosis of myofibroblasts
    • Gressner, A. M. (1998). The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell and Tissue Research 292, 447-452.
    • (1998) Cell. and Tissue Research , vol.292 , pp. 447-452
    • Gressner, A.M.1
  • 19
    • 29144460636 scopus 로고    scopus 로고
    • Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats
    • Gui, S. Y., Wei, W., Wang, H., Wu, L., Sun, W. Y., Chen, W. B. and Wu, C. Y. (2006). Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats. Journal of Ethnopharmacology 103, 154-159.
    • (2006) Journal of Ethnopharmacology , vol.103 , pp. 154-159
    • Gui, S.Y.1    Wei, W.2    Wang, H.3    Wu, L.4    Sun, W.Y.5    Chen, W.B.6    Wu, C.Y.7
  • 20
    • 0345447641 scopus 로고    scopus 로고
    • IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site
    • Hebenstreit, D., Luft, P., Schmiedlechner, A., Regl, G., Frischauf, A. M., Aberger, F., Duschl, A. and Horejs-Hoeck, J. (2003). IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site. Journal of Immunology 171, 5901-5907.
    • (2003) Journal of Immunology , vol.171 , pp. 5901-5907
    • Hebenstreit, D.1    Luft, P.2    Schmiedlechner, A.3    Regl, G.4    Frischauf, A.M.5    Aberger, F.6    Duschl, A.7    Horejs-Hoeck, J.8
  • 21
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • quiz 691
    • Hershey, G. K. (2003). IL-13 receptors and signaling pathways: an evolving web. Journal of Allergy and Clinical Immunology 111, 677-690; quiz 691.
    • (2003) Journal of Allergy and Clinical Immunology , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 22
  • 24
    • 42649116083 scopus 로고    scopus 로고
    • A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages
    • Huang, H., Chang, E. J., Lee, Y., Kim, J. S., Kang, S. S. and Kim, H. H. (2008). A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages. Inflammation Research 57, 189-198.
    • (2008) Inflammation Research , vol.57 , pp. 189-198
    • Huang, H.1    Chang, E.J.2    Lee, Y.3    Kim, J.S.4    Kang, S.S.5    Kim, H.H.6
  • 25
    • 38149096108 scopus 로고    scopus 로고
    • Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells
    • Hung, J. Y., Yang, C. J., Tsai, Y. M., Huang, H. W. and Huang, M. S. (2008). Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells. Clinical and Experimental Pharmacology and Physiology 35, 141-147.
    • (2008) Clinical and Experimental Pharmacology and Physiology , vol.35 , pp. 141-147
    • Hung, J.Y.1    Yang, C.J.2    Tsai, Y.M.3    Huang, H.W.4    Huang, M.S.5
  • 26
    • 4744362174 scopus 로고    scopus 로고
    • Interleukin-13 stimulates the transcription of the human alpha2 (I) collagen gene in human dermal fibroblasts
    • Jinnin, M., Ihn, H., Yamane, K. and Tamaki, K. (2004). Interleukin-13 stimulates the transcription of the human alpha2 (I) collagen gene in human dermal fibroblasts. Journal of Biological Chemistry 279, 41783-41791.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 41783-41791
    • Jinnin, M.1    Ihn, H.2    Yamane, K.3    Tamaki, K.4
  • 27
    • 0032519993 scopus 로고    scopus 로고
    • Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
    • Kaplan, M. H., Whitfield, J. R., Boros, D. L. and Grusby, M. J. (1998). Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. Journal of Immunology 160, 1850-1856.
    • (1998) Journal of Immunology , vol.160 , pp. 1850-1856
    • Kaplan, M.H.1    Whitfield, J.R.2    Boros, D.L.3    Grusby, M.J.4
  • 29
    • 0021978386 scopus 로고
    • Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin
    • Kimura, M., Kimura, I. and Nojima, H. (1985). Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin. Japanese Journal of Pharmacology 37, 395-399.
    • (1985) Japanese Journal of Pharmacology , vol.37 , pp. 395-399
    • Kimura, M.1    Kimura, I.2    Nojima, H.3
  • 30
    • 0021228691 scopus 로고
    • Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse
    • Kimura, M., Kimura, I., Takahashi, K., Muroi, M., Yoshizaki, M., Kanaoka, M. and Kitagawa, I. (1984). Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse. Japanese Journal of Pharmacology 36, 275-282.
    • (1984) Japanese Journal of Pharmacology , vol.36 , pp. 275-282
    • Kimura, M.1    Kimura, I.2    Takahashi, K.3    Muroi, M.4    Yoshizaki, M.5    Kanaoka, M.6    Kitagawa, I.7
  • 31
    • 43049141859 scopus 로고    scopus 로고
    • Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol
    • Lee, B., Shin, Y. W., Bae, E. A., Han, S. J., Kim, J. S., Kang, S. S. and Kim, D. H. (2008). Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Archives of Pharmacology Research 31, 445-450.
    • (2008) Archives of Pharmacology Research , vol.31 , pp. 445-450
    • Lee, B.1    Shin, Y.W.2    Bae, E.A.3    Han, S.J.4    Kim, J.S.5    Kang, S.S.6    Kim, D.H.7
  • 32
    • 0037458403 scopus 로고    scopus 로고
    • The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats
    • Li, C., Luo, J., Li, L., Cheng, M., Huang, N., Liu, J. and Waalkes, M. P. (2003). The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats. Life Science 72, 1563-1571.
    • (2003) Life Science , vol.72 , pp. 1563-1571
    • Li, C.1    Luo, J.2    Li, L.3    Cheng, M.4    Huang, N.5    Liu, J.6    Waalkes, M.P.7
  • 33
    • 33645022034 scopus 로고    scopus 로고
    • Protective effect of paeoniflorin on immunological liver injury induced by bacillus Calmette-Guerin plus lipopolysaccharide: Modulation of tumour necrosis factor-alpha and interleukin-6 MRNA
    • Liu, D. F., Wei, W. and Song, L. H. (2006). Protective effect of paeoniflorin on immunological liver injury induced by bacillus Calmette-Guerin plus lipopolysaccharide: modulation of tumour necrosis factor-alpha and interleukin-6 MRNA. Clinical and Experimental Pharmacology and Physiology 33, 332-339.
    • (2006) Clinical and Experimental Pharmacology and Physiology , vol.33 , pp. 332-339
    • Liu, D.F.1    Wei, W.2    Song, L.H.3
  • 35
    • 0032510452 scopus 로고    scopus 로고
    • A distinct role for interleukin-13 in Th2-cell-mediated immune responses
    • Mckenzie, G. J., Bancroft, A., Grencis, R. K. and Mckenzie, A. N. (1998). A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Current Biology 8, 339-342.
    • (1998) Current Biology , vol.8 , pp. 339-342
    • Mckenzie, G.J.1    Bancroft, A.2    Grencis, R.K.3    Mckenzie, A.N.4
  • 37
    • 0037451126 scopus 로고    scopus 로고
    • Decoy receptors in the regulation of T helper cell type 2 responses
    • Mckenzie, A. N. and Fallon, P. G. (2003). Decoy receptors in the regulation of T helper cell type 2 responses. Journal of Experimental Medicine 197, 675-679.
    • (2003) Journal of Experimental Medicine , vol.197 , pp. 675-679
    • Mckenzie, A.N.1    Fallon, P.G.2
  • 40
    • 43549111605 scopus 로고    scopus 로고
    • Inflammation in Parkinson's disease: An update
    • Smith, P. F. (2008). Inflammation in Parkinson's disease: an update. Current Opinion in Investigational Drugs 9, 478-484.
    • (2008) Current Opinion in Investigational Drugs , vol.9 , pp. 478-484
    • Smith, P.F.1
  • 42
    • 34347350269 scopus 로고    scopus 로고
    • Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats
    • Sun, W. Y., Wei, W., Wu, L., Gui, S. Y. and Wang, H. (2007). Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. Journal of Ethnopharmacology 112, 514-523.
    • (2007) Journal of Ethnopharmacology , vol.112 , pp. 514-523
    • Sun, W.Y.1    Wei, W.2    Wu, L.3    Gui, S.Y.4    Wang, H.5
  • 43
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Ta, W. (2008). Cellular and molecular mechanisms of fibrosis. Journal of Pathology 214, 199-210.
    • (2008) Journal of Pathology , vol.214 , pp. 199-210
    • Ta, W.1
  • 44
    • 0014545851 scopus 로고
    • Pharmacological studies on herb paeony root. II. Anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect of paeoniflorin and combined effects with licorice component Fm 100
    • Takagi, K. and Harada, M. (1969). [Pharmacological studies on herb paeony root. II. Anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect of paeoniflorin and combined effects with licorice component Fm 100]. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 89, 887-892.
    • (1969) Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan , vol.89 , pp. 887-892
    • Takagi, K.1    Harada, M.2
  • 46
    • 34250825540 scopus 로고    scopus 로고
    • Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients
    • Talaat, R. M., El-Bassiouny, A. I., Osman, A. M., Yossif, M., Charmy, R. and Al-Sherbiny, M. M. (2007). Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients. Parasitology Research 101, 289-299.
    • (2007) Parasitology Research , vol.101 , pp. 289-299
    • Talaat, R.M.1    El-Bassiouny, A.I.2    Osman, A.M.3    Yossif, M.4    Charmy, R.5    Al-Sherbiny, M.M.6
  • 50
    • 1542269021 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: A new approach for asthma
    • Wong, W. S. and Leong, K. P. (2004). Tyrosine kinase inhibitors: a new approach for asthma. Biochimica et Biophysica Acta 1697, 53-69.
    • (2004) Biochimica et Biophysica Acta , vol.1697 , pp. 53-69
    • Wong, W.S.1    Leong, K.P.2
  • 51
    • 33947431324 scopus 로고    scopus 로고
    • Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis
    • Wu, H., Wei, W., Song, L., Zhang, L., Chen, Y. and Hu, X. (2007). Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. International Immunopharmacology 7, 662-673.
    • (2007) International Immunopharmacology , vol.7 , pp. 662-673
    • Wu, H.1    Wei, W.2    Song, L.3    Zhang, L.4    Chen, Y.5    Hu, X.6
  • 52
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn, T. A. (2003). IL-13 effector functions. Annual Review of Immunology 21, 425-456.
    • (2003) Annual Review of Immunology , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 54
    • 0032837712 scopus 로고    scopus 로고
    • An improved method for the purification of stellate cells from rat liver with dichloromethylene diphosphate (CL2MDP)
    • Yata, Y. E. S., Suzuki, S., Li, X. K., Tamura, A., Kimura, H., Takahara, T. and Watanabe, A. (1999). An improved method for the purification of stellate cells from rat liver with dichloromethylene diphosphate (CL2MDP). Methods in Cell Science 21, 19-24.
    • (1999) Methods in Cell. Science , vol.21 , pp. 19-24
    • Yata, Y.E.S.1    Suzuki, S.2    Li, X.K.3    Tamura, A.4    Kimura, H.5    Takahara, T.6    Watanabe, A.7
  • 56
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokine signalling and immune regulation
    • Yoshimura, A. N. T. and Kubo, M. (2007). SOCS proteins, cytokine signalling and immune regulation. Nature Reviews Immunology 7, 454-465.
    • (2007) Nature Reviews Immunology , vol.7 , pp. 454-465
    • Yoshimura, A.N.T.1    Kubo, M.2
  • 57
    • 51749113816 scopus 로고    scopus 로고
    • Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast - Like synoviocytes of collagen induced arthritic rats
    • Zhang, L. L., Wei, W., Wang, N. P., Wang, Q. T., Chen, J. Y., Chen, Y., Wu, H. and Hu, X. Y. (2008a). Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast - like synoviocytes of collagen induced arthritic rats. Inflammation Research 57, 388-395.
    • (2008) Inflammation Research , vol.57 , pp. 388-395
    • Zhang, L.L.1    Wei, W.2    Wang, N.P.3    Wang, Q.T.4    Chen, J.Y.5    Chen, Y.6    Wu, H.7    Hu, X.Y.8
  • 58
    • 44249126748 scopus 로고    scopus 로고
    • The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats
    • Zhang, X. J., Li, Z., Leung, W. M., Liu, L., Xu, H. X. and Bian, Z. X. (2008b). The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. Journal of Pain 9, 497-505.
    • (2008) Journal of Pain , vol.9 , pp. 497-505
    • Zhang, X.J.1    Li, Z.2    Leung, W.M.3    Liu, L.4    Xu, H.X.5    Bian, Z.X.6
  • 59
    • 40049087865 scopus 로고    scopus 로고
    • Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance
    • Zhi-Xin Zhao, Q.-X. C., Xiao-Mou Peng, Yu-Tian Chong, Zhi-Liang Gao (2008). Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance. World Journal of Gastroenterology 14, 607-611.
    • (2008) World Journal of Gastroenterology , vol.14 , pp. 607-611
    • Zhao, Z.-X.1    C, Q.-X.2    Peng, X.-M.3    Chong, Y.-T.4    Gao, Z.-L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.