The cell biology of liver fibrogenesis - An imbalance of proliferation, growth arrest and apoptosis of myofibroblasts

Cell and Tissue Research

Volumn 292, Issue 3, 1998, Pages 447-452

  Gressner, Axel M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Fibrogenesis; Hepatic stellate cells; Liver

Indexed keywords

APOPTOSIS; CELL PROLIFERATION; CYTOLOGY; FIBROGENESIS; GROWTH INHIBITION; LIVER FIBROSIS; MYOFIBROBLAST; PRIORITY JOURNAL; REVIEW; STELLATE CELL;

APOPTOSIS; CELL DIVISION; FIBROBLASTS; HUMANS; LIVER CIRRHOSIS;

HEXAPODA; INSECTA;

EID: 0031819504     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410051073     Document Type: Review

References (52)

1. Aterman K (1986) The parasinusoidal cells of the liver: a historical account. Histochem J 18:279-305
2. Atsukawa K, Saito H, Toda K, Inagaki H, Kumagai N, Tsuchimoto K, Ebinuma H, Ohishi T, Takahashi M, Ishii H (1997) Interleukin-6 as an autocrine growth factor in human fibroblasts and rat Ito cells. Hepatology 26:449A
3. Bachem MG, Melchior R, Gressner AM (1989) The role of thrombocytes in liver fibrogenesis: effects of platelet lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells. J Clin Chem Clin Biochem 27:555-565
4. Bachem MG, Meyer DM, Melchior R, Sell KM, Gressner AM (1992) Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells - a potential mechanism of self-perpetuation in liver fibrogenesis. J Clin Invest 89:19-27
5. Ballardini G, Groff P, DeGiorgi LB, Schuppan D, Bianchi FB (1994) Ito cell heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology 19:440-446
6. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 5:271-277
7. Bouwens L, Wisse E (1988) Tissue localization and kinetics of pit cells or large granular lymphocytes in the liver of rats treated with biological response modifiers. Hepatology 8:46-52
8. Bouwens L, Wisse E (1992) Pit cells in the liver. Liver 12:3-9
9. Burt AD (1993) Cellular and molecular aspects of hepatic fibrosis. J Pathol 170:105-114
10. Chunfang Gao, Gressner G, Zoremba M, Gressner AM (1996) Transforming growth factor-beta (TGF-beta) expression in isolated and cultured rat hepatocytes. J Cell Physiol 167:394-405
11. De La Hall PM (1985) The pathological spectrum of alcoholic liver disease. Pathology 17:209-218
12. Feldmann G (1997) Liver apoptosis. J Hepatol 26:1-11
13. Friedman SL, Arthur JP (1989) Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. J Clin Invest 84:1780-1785
14. Friedman SL, Roll FJ, Boyles J, Bissell DM (1985) Hepatic lipocytes: the principal collagen-producine cells of normal rat liver. Proc Natl Acad Sci USA 82:8681-8685
15. Geerts A, Greenwel P, Cunningham M, DeBleser P, Rogiers V, Wisse E, Rojkind M (1993) Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial. Kupffer and fat storing cells by Northern hybridization analysis. J Hepatol 19:148-158
16. Gressner AM (1992) Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules. Z Gastroenterol (Suppl 1) 30:5-16
17. Gressner AM (1994) Perisinusoidal lipocytes and fibrogenesis. Gut 35:1331-13.33
18. Gressner AM (1996) Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int 49:S39-S45
19. Gressner AM, Bachem MG (1994) Cellular communications and cell-matrix interactions in the pathogenesis of fibroproliferative diseases: liver fibrosis as a paradigm. Ann Biol Clin 52:205-226
20. Gressner AM, Schäfer S (1989) Comparison of sulphated glycosaminoglycan and hyaluronate synthesis and secretion in cultured hepatocytes, fat storing cells, and Kupffer cells. J Clin Chem Clin Bioehem 27:141-149
21. Gressner AM, Lotfi S, Gressner G, Lahme B (1992) Identification and partial characterization of a hepatocyte-derived factor promoting proliteration of cultured fat storing cells (parasinusoidal lipocytes). Hepatology 16:1250-1266
22. Gressner AM, Lahme B, Brenzel A (1995) Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells. Hepatology 22:1507-1518
23. Gressner AM, Polzar B, Lahme B, Mannherz HG (1996) Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta. Hepatology 23:571-581
24. Harrington EA, Bennett MR, Fanidi A, Evan GI (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13:3286-3295
25. Hautekeete ML, Geerts A (1997) The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch B Cell Pathol 430:195-207
26. Hendriks HFJ, Verhoofstad WAMM, Brouwer A, De Leeuw AM, Knook DL (1985) Persinusoidal fat storing cells are the main vitamin A-storage sites in rat liver. Exp Cell Res 160:138-149
27. Housset C, Rockey DC, Bissell DM (1993) Endothelin receptors in rat liver - lipocytes as a contractile target for endothelin-1. Proc Natl Acad Sci USA 90:9266-9270
28. Housset CN, Rockey DC, Friedman SL, Bissell DM (1995) Hepatic lipocytes: a major target for endothelin-1. J Hepatol 22:55-60
29. Iredale JP, Northrop M, Vincent K, Mann DA, Arthur MJP (1997) Possible role of apoptosis in regulating activated stellate cell numbers during liver injury. Hepatology 26: 132A
30. Kim HRC, Upadhyay S, Li GY, Palmer KC, Deuel TF (1995) Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc Natl Acad Sci USA 92:9500-9504
31. Maher JJ, McGuire RF (1990) Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 86:1641-1648
32. Martins LM, Earnshaw WC (1997) Apoptosis: alive and kicking in 1997. Trends Cell Biol 7:111-114
33. Matsuoka M, Tsukamoto H (1990) Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor-beta: implication of a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 11:599-605
34. Meyer DH, Bachem MG, Gressner AM (1990) Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type-beta 1 and type-alpha. Biochem Biophys Res Commun 171:1122-1129
35. Oshimi Y, Oda S, Honda Y, Nagata S, Miyazaki S (1996) Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells. J Immunol 157:2909-2915
36. Patel T, Gores GJ (1995) Apoptosis and hepatobiliary disease. Hepatology 21:1725-1741
37. Pinzani M (1995a) Hepatic stellate (Ito) cells: expanding roles for a liver-specific pericyte. J Hepatol 22:700-706
38. Pinzani M (1995b) Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 66:387-412
39. Pinzani M, Gesualdo L, Sabbah GM, Abboud HE (1989) Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat storing cells. J Clin Invest 84:1786-1793
40. Pinzani M, Milani S, Grappone C, Weber FL, Gentilini P, Abboud HE (1994) Expression of platelet-derived growth factor in a model of acute liver injury. Hepatology 19:701-707
41. Pinzani M, Gentilini A, Caligiuri A, De Franco R, Pellegrini G, Milani S, Marra F, Gentilini P (1995) Transforming growth factor beta1 regulates platelet-derived growth factor receptor beta subunit in human liver fat storing cells. Hepatology 21:232-239
42. Pinzani M, Milani S, Defranco R, Grappone C, Caligiuri A, Gentilini A, Tostiguerra C, Maggi M, Failli P, Ruocco C, Gentilini P (1996) Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110:534-548
43. Ramadori G (1991) The stellate cell (Ito-cell, fat storing cell, lipocyte, perisinusoidal cell) of the liver. Virchows Arch B Cell Pathol 61:147-158
44. Roth S, Schurek J, Gressner AM (1997) Expression and release of the latent TGF-beta binding protein (LTBP) by hepatocytes from rat liver. Hepatology 25:1398-1405
45. Roth S, Michel K, Gressner AM (1998) Latent transforming growth factor beta in liver parenchymal cells, its injury-dependent release and paracrine effects on hepatic stellate cells. Hepatology 27: (in press)
46. Rudin CM, Thompson CB (1997) Apoptosis and disease: regulation and clinical relevance of programmed cell death. Annu Rev Med 48:267-281
47. Saile B, Knittel T, Matthes N, Schott P, Ramadori G (1997) CD95/CD95L-mediated apoptosis of the hepatic stellate cell - a mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 151:1265-1272
48. Schäfer S, Zerbe O, Gressner AM (1987) The synthesis of proteoglycans in fat storing cells of rat liver. Hepatology 7:680-687
49. Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y, Kaneda K (1996) INF-gamma-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol 157:3967-3973
50. Vanderkerken K, Bouwens L, De Neve W, Van den Berg K, Baekeland M, Helens N, Wisse H (1993) Origin and differentiation of hepatic natural killer cells (pit cells). Hepatology 18:919-925
51. Wake K, Sato T (1993) Intralobular heterogeneity of perisinusoidal stellate cells in porcine liver. Cell Tissue Res 273:227-237
52. Wong L, Yamasaki G, Johnson RJ, Friedman SL (1994) Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94:1563-1569