Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Parasitology Research

Volumn 101, Issue 2, 2007, Pages 289-299

  Talaat, Roba M ^a   El Bassiouny, Azza I ^b   Osman, Ahmed M ^c   Yossif, Magdy ^d   Charmy, Ragia ^c   Al Sherbiny, Maged M ^c  

^a MENOUFIA UNIVERSITY   (Egypt)

^b Giza   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

^d THEODOR BILHARZ RESEARCH INSTITUTE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANALYTIC METHOD; ARTICLE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; ECHOGRAPHY; EGYPT; FEMALE; HUMAN; IMMUNOSTIMULATION; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PARASITOSIS; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; WORM;

ADOLESCENT; ANTIGENS, HELMINTH; BIOLOGICAL MARKERS; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; CYTOKINES; EGYPT; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SCHISTOSOMIASIS MANSONI; STATISTICS;

EID: 34250825540     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-007-0478-y     Document Type: Article

References (73)

1. Abbas AK, Murphy K, Sher A (1996) Functional diversity of helper T-lymphocytes. Nature 383:5787-5790
2. Abdel-Wahab MF (1982) Schistosomiasis in Egypt. CRC, Boca Raton, FL
3. Abdel-Wahab MF, Esmat G, Milad M, El-Boraey Y, Strickland GT (1992) Grading of hepatic schistosomiasis by the use of ultrasonography. Am J Trop Med Hyg 46:403-408
4. Abdel-Wahab MF, Esmat G, Farrag A, El-Boraey Y, Strickland GT (1993) Ultrasonographic prediction of esophageal varices in schistosomiasis mansoni. Am J Gastroenterol 88:560-563
5. Ali H, Haribabu B, Richardson RM, Snyderman R (1997) Mechanisms of inflammation and leukocyte activation. Med Clin North Am 81:1-28
6. Araujo I, deJesus AR, Bacellar O, Sabin E, Pearce E, Carvalho EM (1996) Evidence of a T helper type-2 activation in human schistosomiasis. Eur J Immunol 26:1399-1403
7. Bahia-Oliveira LM, Gazzinelli G, Eloi-Santos M, Cunha-Melo JR, Alves-Oliveira LF, Silvaira AM, Viana IR, Carmo J, Souza A, Correa-Oliveira R (1992) Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni. Trans R Soc Trop Med Hyg 86:57-61
8. Bahia-Oliveira LM, Simpson AJ, Alves-Oliveira LF, Carvalho C, Silveira AM, Viana IR, Cunha-Melo JR, Hagan P, Gazzinelli G, Correa-Oliveira R (1996) Evidence that cellular immune responses to soluble and membrane associated antigens are independently regulated during human schistosomiasis mansoni. Parasite Immunol 18:53-63
9. Bica I, Hamer DH, Stadecker (2000) Hepatic schistosomiasis. Infect Dis Clin North Am 148:346-350
10. Booth M, Vennervald BJ, Kabatereine NB, Kazibwe F, Ouma JH, Kariuki CH, Muchiri E, Kadzo H, Ireri E, Kimani G, Mwatha JK, Dunne DW (2004) Periportal fibrosis in human S. mansoni infection is associated with low IL-10, low IFN-γ, high TNF-α or low RANTES, depending on age and gender. J Immunol 172:1295-1303
11. Capron A, Dombrowicz D, Capron M (1999) Regulation of the immune response in experimental and human schistosomiasis: the limits of an attractive paradigm. Microbes Infect 1:485-490
12. Cardell S, Sander B, Moller G (1991) Helper interleukines are produced by both CD4 and CD8 splenic T cells after mitogen stimulation. Eur J Immunol 21:2495-2500
13. Cheever AW, Poindexter RW, Wynn TA (1999) Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant TNF-α treatment. Infect Immun 67:2201-2208
14. Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104(6):777-785
15. Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA (2003) Studies of murine schistosomiasis reveal interleukin-13 blockage as a treatment for established and progressive liver fibrosis. Hepatology 34:273-282
16. Chitsulo L, Engles D, Montresor A, Savioli L (2000) The global status of schistosomiasis and its control. Acta Trop 77:41-51
17. + T-cell subsets in vivo. Immunol Rev 123:189-195
18. Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G (1986) Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg 35:793-802
19. Colley DG, Parra JC, Montesano MA, Lima M, Nascimento E, Doughty BL, Goes A, Gazzinelli G (1987) Immunoregulation in human schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms. Mem Inst Oswaldo Cruz 82:105-109
20. Contigli C, Doughty BL, Cone JC, Goes AM (1994) Recognition of different Schistosoma mansoni antigens by specific human T cell clones. Cell Immunol 154:77-87
21. Contigli C, Silva-Teixeira DN, Delprete G, D'Elios MM, DeCarli M, Manghetti M, Amedei A, Almerigogna F, Lambertucci JR, Goes AM (1999) Phenotype and cytokine profile of Schistosoma mansoni specific T cells and clones derived from schistosomiasis patients with distinct clinical forms. Clin Immunol 91:338-344
22. Correa-Oliveira R, Malaquias LC, Falcao PL, Viana IR, Bahia-Oliveira LM, Silveira AM, Fraga LA, Prata A, Coffman RL, Lambertucci JR, Cunha-Melo JR, Martins-Filho OA, Wilson RA, Gazzinelli G (1998) Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection. Braz J Med Biol Res 31(1):171-177
23. deJesus AR, Miranda DG, Miranda RG, Araujo MI, Magalhaes A, Bacelluer M, Carvalho EM (2000) Morbidity associated with S. mansoni infected determined by ultrasonography in an endemic area of Brazil. Am J Trop Med Hyg 63:1-4
24. deJesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, deJesus AA, Siva A, Santana LB, Pearce E, Carvalho E (2004) Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection. Infect Immun 72(6):3391-3397
25. Denie C, Vachiery F, Elman A, Soupison T, Gadano A, Moreau R, Lebrec D (1996) Systemic and splanchnic hemodynamic changes in patients with hepatosplenic schistosomiasis. Liver 16:309-312
26. Else KJ, Entwhishe GM, Grencis RK (1993) Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred mouse infected with Tricburis muris. Parasite Immunol 15:595-600
27. Falcao PL, Malaquias LC, Martins-Filho OA, Silveira AM, Passos VM, Prata A, Gazzinelli G, Coffman RL, Correa-Oliveira R (1998) Human schistosomiasis mansoni: IL-10 modulates the in vitro granuloma formation. Parasite Immunol 20:447-454
28. Flores-Villanueva PO, Zheng XX, Strrom TB, Stadeker MJ (1996) Recombinant IL-10 and IL-10/FC treatment down regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J Immunol 156:3315-3320
29. Freeman GL, Montesano MA, Secor WE, Colley DE, Howard M, Gazzinelli G, Katz N, Rocha RS, Colley DG (1983) Immune responses during human schistosomiasis mansoni VIII. Differential in vitro cellular responsiveness to adult worm and schistosomular tegumental preverentains. Am J Trop Med Hyg 32:326-333
30. Freeman GL Jr, Montesano MA, Secor WE, Colley DG, Howard MJ, Bosshardt SC (1996) Immunopathogenesis and immunoregulation in schistosomiasis. Distinct chronic pathologic syndromes in CBA/J mice. Ann N Y Acad Sci. Oct 25;797:151-165
31. Gazzinelli G, Katz N, Rocha RS, Colley DG (1983) Immune responses during human schistosomiasis mansoni VIII. Differential in vitro cellular reapensiveness to adult worm and schistosomular tegumental preverentains. Am J Trop Med Hyg 32:326-333
32. Gazzinelli G, Lambertucci JR, Katz N, Rocha RS, Lima MS, Colley DG (1985) Immune responses during human schistosomiasis mansoni XI. Immunology status of patients with acute infections and after treatment. J Immunol 135:2121-2127
33. Gazzinelli G, Montesano MA, Correa-Oliveira R, Lima MS, Katz N, Rocha RS, Colley DG (1987) Immune responses in different groups of schistosomiasis patients. Mem Inst Oswaldo Cruz 82:95-100
34. Grzych JM, Pearce E, Cheever A, Caulada ZA, Caspar P, Heiny S, Lewis F, Sher A (1991) Egg deposition is the major stimulus for the production of the cytokines in murine schistosomiasis mansoni. J Immunol 146:1322-1326
35. Henderson GS, Lu X, McCurly TL, Colley DG (1992) In vivo molecular analysis lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantitation of IL-4 mRNA, IFN-γ mRNA, and IL-2 mRNA levels in granulomatous livers, mesenteric lymph nodes and spleens during the course of modulation. J Immunol 148:2261-2269
36. Henri S, Chevillard C, Margani A, Paris P, Gaudart J, Camilla C, Dessein H, Montero F, Elwali NE, Saeed OK, Magzoub M, Dessein AJ (2002) Cytokine regulation of periportal fibrosis in human infected with Schistosoma: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease. J Immunol 69:929-936
37. Katz N, Chaves A, Pellergrino J (1972) A simple device for quantitative stool thick smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 14:397-400
38. King CL, Mahanty S, Kumaraswami V, Abrams JS, Regunathen J, Jayaraman K, Ottesen EA, Nutman TB (1993) Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. J Clin Invest 92:1667-1673
39. King CL, Medhat A, Malhotra I, Nafeh M, Helmy A, Khaudary J, Ibrahim S, El-Sherbiny M, Zaky S, Stup J, Brustoski K, Shehata M, Shata MT (1996) Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J Immunol 156:4715-4721
40. King C, Xianil J, Stavitsky B (2001) Murine schistosomiasis mansoni: coordinate cytokine regulation and differences in cellular immune response of granuloma cells and splenocytes to endogenous and exogenous schistosome egg antigens. Parasite Immunol 23:607-780
41. Kovacs EJ (1991) Fibrogenic cytokines; the role of immune mediators in the development of scar tissue. Immunol Today 12:17-23
42. Leptak CL, McKerrow JH (1997) Schistosome egg granulomas and hepatic expression of TNF-α are dependent on immune priming during parasite maturation. J Immunol 158:301-307
43. Magalhaes A, Miranda DG, Miranda RG, Araujo MI, deJesus AA, Silva A, Santana L, Pearce E, Carvalho EM, deJesus AR (2004) Cytokine profile associated with human chronic schistosomiasis mansoni. Mem Inst Oswaldo Cruz 99:21-26
44. Malaquias LC, Falcao PL, Silveira AM, Gazzinelli G, Prata A, Coffman RL, Pizziolo V, Souza CP, Colley DG, Correa-Oliveira R (1997) Cytokine regulation of human immune response to Schistosoma mansoni: analysis of the role of IL-4, IL-5 and IL-10 on peripheral blood mononuclear cell responses. Scand J Immunol 46:393-398
45. Margucrite M, Gallissot MC, Diagne M, Moreau C, Diakkhate MM, Roberts M, Capron A (1999) Cellular immune responses of a Senegalese community recently exposed to Schistosoma mansoni: correlations of infection level with age and inflammatory cytokine production by soluble egg antigen specific T cell. Trop Med Int Health 4:530-543
46. Martins RD, Szejnfeld J, Lima FG, Ferrari AP (2000) Endoscopic, ultrasonographic and US-Doppler parameters as indicators of variceal bleeding in patients with schistosomiasis. Dig Dis 45:1013-1018
47. Martins-Filho OA, Cunha-Melo JR, Lambertucci JR, Silveira AM, Colley DG, Gazzinelli G, Correa-Oliveira R (1999) Clinical forms of human Schistosoma mansoni infection are associated with differential activation of T cell subsets and costimulatory molecules. Dig Dis Sci 44:570-577
48. McKerrow JH (1997) Cytokine induction and exploitation in schistosome infections. Parasitology 115:5107-5112
49. Montenegro SM, Miranda P, Mahanty S, Abath FG, Teixeira KM, Coutinho EM, Brinkman J, Goncalves I, Domingues LA, Domingues AL, Sher A, Wynn TA (1999) Cytokine production in acute versus chronic human schistosomiasis mansoni: the cross-regulatory role of IFN-γ and IL-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. J Infect Dis 179:1502-1514
50. Moukoko CE, El-Wali N, Saeed OK, Ali QM, Gaudart J, Dessein A, Chevillard C (2003) No evidence for a major effect of tumor necrosis factor alpha gene polymorphism in periportal fibrosis caused by S. mansoni infection. Infect Immun 71:5456-5460
51. Mwatha JK, Kimani G, Kamau T, Mbugua GG, Ouma JH, Muma J, Fulforf JC, Jones FM, Butterworth AE, Roberts MB, Dunne DW (1998) High levels of TNF, soluble TNF receptors, soluble ICAM-1 and IFN-γ but low levels of IL-5 are associated with hepatosplenic disease in human schistosomiasis mansoni. J Immunol 160:1992-1998
52. Paul WE, Sher RA (1994) Lymphocyte responses and cytokines. Cell 76:241-245
53. Peters M (1996) Action of cytokines on the immune response and viral interactions. Hepatology 23:909-916
54. Peters PA, Warren KS, Mahmoud AAF (1976) Rapid accurate quantification of schistosome eggs via nucleopore filters. J Parasitol 62:154-155
55. Raziuddin S, Masihuzzaman M, Shetty S, Ibrahim A (1993) TNF-α production in schistosomiasis with carcinoma of urinary bladder. J Clin Immunol 13:23-29
56. Rezende SA, Silva-Teixeira DV, Drummand SC, Goes M (1997) IL-10 plays a role in the modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes. Scand J Immunol 46:96-102
57. Ribeiro de Jesus AM, Almeida RP, Bacellar O (1993) Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis. Eur J Immunol 23:152-158
58. Richter J (2000) Evaluation of schistosomiasis-induced pathology after therapy and interruption of exposure to schistosomes: a review of ultrasonographic studies. Acta Trop 77:111-131
59. Roberts M, Butterworth AE, Kimani G, Kaman T, Fulford AJ, Dunne DW, Ouma JH, Sturrock RF (1993) Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to infection. Infect Immun 61:4989-4993
60. Rocklin RE, Tracy JW, El-Khaly A (1981) Activation of antigen specific suppressor cells in human schistosomiasis mansoni by fractions of soluble egg antigens monoadherent to ConA Sepharose. J Immunol 127:2314-2318
61. Romagnani S (1994) Lymphokine production by human T cells in diseases states. Ann Rev Immunol 12:227-230
62. Sahai H, Ageel MI (2000) The analysis of variance, fixed, random and mixed model. Birkhauser, Boston
63. Stadecker MJ (1999) The regulatory role of the antigen-presenting cell in the development of hepatic immunopathology during infection with Schistosoma mansoni. Pathobiology 67:269-272
64. Talaat RM, El-Bassiouny E, Osman A, Yossif M, Charmy R, Al-Sherbiny M (2005) Circulating adhesion molecules in patients with different clinical forms of S. mansoni infection. Egyp J Immunol 12(2):143-154
65. Viana IR, Sher A, Carvalho OS, Massara CL, Eloi-Santos SM, Pearce EJ, Colley DG, Gazzinelli G, Correa-Oliveira R (1994) IFN-γ production by peripheral blood mononuclear cells from residents of an area endemic for schistosomiasis mansoni. Trans R Soc Trop Med Hyg 88:466-470
66. Warren KS (1979) The pathogenesis of hepatosplenic schistosomiasis: from man to monkey to mouse to molecule. In: Popper H, Scaffner F (eds) Progress in liver diseases. Grune and Stratton, New York, pp 439-455
67. Williams ME, Montenegro S, Domingues AL, Wynn TA, Teixeira K, Mahanty S, Coutinho A, Sher A (1994) Leukocytes of patients Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigen. J Infect Dis 170:946-954
68. World Health Organization (1993) The control of schistosomiasis. Technical Report. Series 830, Geneva 86
69. Wynn TA, Jankovic D, Hieny S, Zioncheck K, Jardieu P, Cheever AW, Sher A (1995) IL-12 exacerbates rather than suppresses Th2-dependent pathology in the absence of endogenous IFN-γ. J Immunol 154:3999-4002
70. Xu YH, Macedonia J, Sher A, Cheever AW (1991) Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum. Infect Immun 59:2934-2940
71. Zwingenberger K, Irschick E, Siqueira JG, Vergetti A, Correa-Dacal AR, Janssen-Rosseck R, Bienzle U, Huber C, Feldmier H (1989) Release of IL-2 and IFN-γ by peripheral mononuclear cells in human schistosomiasis mansoni infection normalizes after chemotherapy. Scand J Immunol 30:463-471
72. Zwingenberger K, Irschick E, Vergetti-Siqueira JG, Correa-Dacal AR, Feldmair H (1990) TNF-α in hepatosplenic schistosomiasis. Scand J Immunol 31:205-211
73. Zwingenberger K, Hohmann A, Cardoso de Brito M, Ritter M (1991) Impaired balance of IL-4 and IFN-γ production in infections with Schistosoma mansoni and intestinal nematodes. J Immunol 34:243-251