A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 35, 2010, Pages 15391-15396

  Makris, Thomas M ^a   Chakrabarti, Mrinmoy ^b   Münck, Eckard ^b   Lipscomb, John D ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Beta hydroxylation; Dinuclear iron cluster; Nonheme oxygenase; Nonribosomal peptide synthetase; Spectroscopy

Indexed keywords

4 AMINOPHENYLALANINE; CMLA ENZYME; CMLP ENZYME; HYDROXYAMINO ACID; PENICILLINASE; SYNTHETASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; ELECTRON SPIN RESONANCE; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME MECHANISM; FLOW KINETICS; GENE SEQUENCE; HYDROXYLATION; MOSSBAUER SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; TURNOVER TIME;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CHLORAMPHENICOL; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROXYLATION; IRON; KINETICS; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OPERON; PEPTIDE SYNTHASES; PHENYLALANINE; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROSCOPY, MOSSBAUER; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 77957256569     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007953107     Document Type: Article

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