Functional control of the binuclear metal site in the metallo-β-lactamase-like fold by subtle amino acid replacements

Protein Science

Volumn 11, Issue 3, 2002, Pages 707-712

  Gomes, Cláudio M ^a,b   Frazão, Carlos ^a   Xavier, António V ^a   Legall, Jean ^a,c   Teixeira, Miguel ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c Instituto de Tecnologia Química e Biológica ^*  (United States)

Author keywords

lactamase; A type flavoprotein; Bimetallic sites; Evolution; Glyoxalase; Iron; Zinc

Indexed keywords

AMINO ACID; BETA LACTAMASE; FLAVOPROTEIN; GLYOXALASE;

ARTICLE; CATALYST; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; BACILLUS CEREUS; BACTEROIDES FRAGILIS; BETA-LACTAMASES; BINDING SITES; DESULFOVIBRIO; FLAVOPROTEINS; HUMANS; IONS; IRON; METALS; MODELS, MOLECULAR; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS, PROTEIN; STENOTROPHOMONAS MALTOPHILIA; THIOLESTER HYDROLASES; ZINC;

EID: 0036176228     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.31202     Document Type: Article

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