Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus

International Journal of Neuropsychopharmacology

Volumn 13, Issue 7, 2010, Pages 835-843

  Valdizán, Elsa Maria ^a,b,c   Castro, Elena ^a,b,c   Pazos, Angel ^a,b,c  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b University of Cantabria   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

5 HT1A receptor; Agonist dependent activation; G protein coupling; signal transduction

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BUSPIRONE; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONCENTRATION RESPONSE; DORSAL RAPHE NUCLEUS; DRUG EFFICACY; ENZYME ACTIVATION; IC 50; IMMUNOPRECIPITATION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADENYLATE CYCLASE; ANIMALS; BUSPIRONE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SIGNAL TRANSDUCTION;

EID: 77957243728     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709990940     Document Type: Article

References (42)

1. Albert PR, Lembo P, Storring JM, Charest A, et al. (1996). The 5-HT1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology 14, 19-25. (Pubitemid 26047182)
2. Bertin B, Freissmuth M, Breyer RM, Schutz W, et al. (1992). Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits. Journal of Biological Chemistry 267, 8200-8206.
3. Blier P, Lista A, De Montigny C (1993). Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. Journal of Pharmacology and Experimental Therapeutics 265, 16-23. (Pubitemid 23320936)
4. Blier P, Ward NM (2003). Is there a role for 5-HT1A agonists in the treatment of depression? Biological Psychiatry 53, 193-203. (Pubitemid 36135929)
5. Castro ME, D?́az A, Del Olmo E, Pazos A (2003). Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain. Neuropharmacology 44, 93-101. (Pubitemid 36135846)
6. Chen Y, Penington NJ (1996). Differential effects of protein kinase C activation on 5-HT1A receptor coupling to Ca2+ and K+ currents in rat serotonergic neurones. Journal of Physiology 496, 129-137. (Pubitemid 26345581)
7. Clarke WP, Yocca FD, Maayani S (1996). Lack of 5-hydroxytryptamine1A- mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. Journal of Pharmacology and Experimental Therapeutics 277, 1259-1266. (Pubitemid 27167135)
8. Duncan MJ, Davis VA (2005). Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Research 1058, 10-16.
9. Echizen H, Freed CR (1983). In vivo electrochemical detection of extraneuronal 5-hydroxyindole acetic acid and norepinephrine in the dorsal raphe nucleus of urethane-anesthetized rats. Brain Research 277, 55-62. (Pubitemid 13021222)
10. Fabre V, Beaufour C, Evrard A, Rioux A, et al. (2000). Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. European Journal of Neuroscience 12, 2299-2310. (Pubitemid 30497028)
11. Fargin A, Yamamoto K, Cotecchia S, Goldsmith PK, et al. (1991). Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signalling 3, 547-557. (Pubitemid 121006228)
12. Garnovskaya MN, Gettys TW, van Biesen T, Prpic V, et al. (1997). 5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3. Journal of Biological Chemistry 272, 7770-7776.
13. Gettys TW, Fields TA, Raymond JR (1994). Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor. Biochemistry 33, 4283-4290.
14. Harrison C, Traynor JR (2003). The [35S]GTPgammaS binding assay: approaches and applications in pharmacology. Life Sciences 74, 489-508. (Pubitemid 37377904)
15. Hensler JG (2002). Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26, 565-573.
16. Hensler JG (2003). Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. Life Sciences 72, 1665-1682.
17. Heusler P, Pauwels PJ, Wurch T, Newman-Tancredi A, et al. (2005). Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling. Neuropharmacology 49, 963-976. (Pubitemid 41503296)
18. Higgins GA, Bradbury AJ, Jones BJ, Oakley NR (1988). Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphe nucleus of the rat. Neuropharmacology 27, 993-1001.
19. Hoyer D, Hannon JP, Martin GR (2002). Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology Biochemistry and Behavior 71, 533-554. (Pubitemid 34219205)
20. Innis RB, Aghajanian GK (1987). Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. European Journal of Pharmacology 143, 195-204. (Pubitemid 17159934)
21. Johnson RG, Fiorella D, Winter JC, Rabin RA (1997). [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European Journal of Pharmacology 329, 99-106. (Pubitemid 27264864)
22. Kenakin T (1995). Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends in Pharmacological Sciences 16, 232-238.
23. Le Poul E, Boni C, Hanoun N, Laporte AM, et al. (2000). Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 39, 110-122.
24. Liu YF, Jakobs KH, Rasenick MM, Albert PR (1994). G protein specificity in receptor-effector coupling. Analysis of the roles of Go and Gi2 in GH4C1 pituitary cells. Journal of Biological Chemistry 269, 13880-13886. (Pubitemid 24191134)
25. Mannoury la Cour C, Boni C, Hanoun N, Lesch KP, et al. (2001). Functional consequences of 5-HT transporter gene disruption on 5-HT1A receptor-mediated regulation of dorsal raphe and hippocampal cell activity. Journal of Neuroscience 21, 2178-2185. (Pubitemid 32221400)
26. Mannoury la Cour C, El Mestikawy S, Hanoun N, Hamon M, et al. (2006). Regional differences in the coupling of 5-HT1A receptors to G proteins in the rat brain. Molecular Pharmacology 70, 1013-1021. (Pubitemid 44268458)
27. Marazziti D, Palego L, Giromella A, Mazzoni MR, et al. (2002). Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. International Journal of Neuropsychopharmacology 5, 131-140. (Pubitemid 34669828)
28. Meller E, Goldstein M, Bohmaker K (1990). Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. Molecular Pharmacology 37, 231-237. (Pubitemid 20082987)
29. Newman-Tancredi A, Conte C, Chaput C, Verriele L, et al. (1997). Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor: G-protein stoichiometry. Neuropharmacology 36, 451-459. (Pubitemid 27272090)
30. Newman-Tancredi A, Cussac D, Marini L, Millan MJ (2002). Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT1A receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling. Molecular Pharmacology 62, 590-601. (Pubitemid 36329377)
31. Newman-Tancredi A, Martel JC, Assié MB, Buritova J, et al. (2009). Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist. British Journal of Pharmacology 156, 338-353.
32. Palego L, Giromella A, Marazziti D, Borsini F, et al. (1999). Effects of postmortem delay on serotonin and (+)8-OH-DPAT-mediated inhibition of adenylyl cyclase activity in rat and human brain tissues. Brain Research 816, 165-174. (Pubitemid 29225435)
33. Palego L, Giromella A, Marazziti D, Giannaccini G, et al. (2000). Lack of stereoselectivity of 8-hydroxy-2(di-Npropylamino) tetralin-mediated inhibition of forskolinstimulated adenylyl cyclase activity in human pre- and post-synaptic brain regions. Neurochemistry International 36, 225-232. (Pubitemid 30047015)
34. Pazos A, Palacios JM (1985). Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Research 346, 205-230. (Pubitemid 16241111)
35. Penington NJ, Kelly JS (1990). Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron. Neuron 4, 751-758.
36. Pompeiano M, Palacios JM, Mengod G (1992). Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. Journal of Neuroscience 12, 440-453.
37. Raymond JR, Mukhin YV, Gelasco A, Turner J (2001). Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacology and Therapeutics 92, 179-212. (Pubitemid 34251133)
38. Raymond JR, Mukhin YV, Gettys TW, Garnovskaya MN (1999). The recombinant 5-HT1A receptor: G protein coupling and signalling pathways. British Journal of Pharmacology 127, 1751-1764.
39. Raymond JR, Olsen CL, Gettys TW (1993). Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha. Biochemistry 32, 11064-11073.
40. Sprouse JS, Aghajanian GR (1987). Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1, 3-9.
41. Sussman N (1998). Anxiolytic antidepressant augmentation. Journal of Clinical Psychiatry 59, 42-48. (Pubitemid 28249106)
42. Sotelo C, Cholley B, El Mestikawy S, Gozlan H, et al. (1990). Direct immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. European Journal of Neuroscience 2, 1144-1154.