Dedifferentiated cardiomyocytes from chronic hibernating myocardium are ischemia-tolerant

Molecular and Cellular Biochemistry

Volumn 186, Issue 1-2, 1998, Pages 159-168

  Ausma, J ^a,e   Thone F ^b   Dispersyn, G D ^a   Flameng, W ^c   Vanoverschelde, J L ^d   Ramaekers, F C S ^a   Borgers, M ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Apoptosis; Chronic hibernating myocardium; Dedifferentiation; Ischemia

Indexed keywords

CYTOCHROME C; MITOCHONDRIAL ENZYME; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; STRUCTURAL PROTEIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL STRUCTURE; CLINICAL ARTICLE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GLYCOGEN ANALYSIS; HEART MITOCHONDRION; HEART MUSCLE BIOPSY; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN TISSUE; MICROSCOPY; MUSCLE FIBRIL; PROTEIN EXPRESSION;

APOPTOSIS; CALCIUM; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL NUCLEUS; ELECTRON TRANSPORT COMPLEX IV; HIBERNATION; HUMANS; MICROSCOPY, ELECTRON; MULTIENZYME COMPLEXES; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NADH, NADPH OXIDOREDUCTASES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0031756949     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006887803970     Document Type: Article

References (37)

1. Rahimtoola SH: A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72 (suppl V): 123-135, 1985
2. Rahimtoola SH: From coronary artery disease to heart failure: Role of the hibernating myocardium. Am J Cardiol 75: 16E-22E, 1995
3. Borgers M, Thoné F, Wouters L, Ausma J, Shivalkar B, Flameng W: Structural correlates of regional myocardial dysfunction in patients with critically coronary artery stenosis: Chronic hibernation? Cardiovasc Pathol 2: 237-245, 1993
4. Ausma J, Schaart G, Thoné F, Shivalkar B, Flameng W, Depré, Vanoverschelde J, Ramaekers F, Borgers M: Chronic ischemic viable myocardium in man: Aspects of dedifferentiation. Cardiovasc Pathol 4: 29-37, 1995
5. Ausma J, Fürst D, Thoné F, Flameng W, Weber K, Ramaekers F, Borgers M: Molecular changes of titin in chronic hibernating myocardium. J Mol Cell Cardiol 27: 1203-1212, 1995
6. Ausma J, van Eys GJJM, Broers JLV, Thoné F, Flameng W, Ramaekers FCS, Borgers M: Nuclear lamin expression in chronic hibernating myocardium in man. J Mol Cell Cardiol 28: 1297-1305, 1996
7. Elsasser A, Klovekorn W-P, Zimmerman R, Munkel B, Muller K-D, Strasser R, Schaper J: 'Hibernating myocardium': Changes of transcriptional activity. Circulation 94: 1-186, 1996
8. Schwarz ER, Schaper J, vom Dahl J, Altehoefer C, Grohmann B, Schoendube F, Sheehan FH, Uebis R, Buell U, Messmer BJ, Schaper W, Hanrath P: Myocyte degeneration and cell death in hibernating human myocardium. J Am Coll Cardiol 27: 1577-1585, 1996
9. Vanoverschelde JLJ, Wijns W, Depré C, Essamri B, Heyndricks S, Borgers M, Bol A, Melin J: Mechanisms of chronic regional postischemic dysfunction in humans: New insights form the study on non-infarcted collateral dependent myocardium. Circulation 87: 1513- 1523, 1993
10. Maes A, Flameng W, Nuyts J, Borgers M, Shivalkar B, Ausma J, Bormans G, Schiepers C, De Roo M, Mortelmans L: Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings. Circulation 90: 735-745, 1994
11. Flameng W, Wouters L, Sergeant P, Lewi P, Borgers M, Thoné F, Suy R: Multivariate analysis of angiographic histologic and electrocardiographic data in patients with coronary heart disease. Circulation 70: 7-17, 1984
12. Seligman A, Karnovsky M, Wasserkrug H, Hanker I: Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent diaminobenzidine (DAB). J Cell Biol 38: 1-14, 1968
13. Wachstein M, Meisel E: On the histochemical demonstration of glucose-6-phosphatase. J Histochem Cytochem 10: 592, 1956
14. Vandeplassche G, Hermans C, Thone F, Borgers M: Stunned myocardium has increased mitochondrial NADH oxidase and ATPase activities. Cardioscience 2: 47-53, 1991
15. Briggs R, Drath D, Karnovsky ML, Karnovsky MJ: Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method. J Cell Biol 67: 566-586, 1975
16. Van Reempts J, Borgers M, Offner F: Ultrastructural localization of calcium in the rat retina with a combined oxalate-pyroantimonate technique. Histochem J 14: 517-522, 1982
17. ++ distribution in the isolated working rabbit heart after ischemia. Am J Pathol 126: 92-102, 1987
18. Gottlieb RA, Buriesin KO, Kioner, RA, Babior BM, Engler RL: Reperfusion injury induces apoptosis in rabbit myocytes. J Clin Invest 94: 1621-1628, 1994
19. Dispersyn GD, Ausma J, Thoné F, Flameng W, Vanoverschelde J-U, Ramaekers FCS, Borgers M: Chronic hibernating myocardium and chronic atrial fibrillation; a prelude to apoptosis? Submitted
20. Stick R, Hansen P: Changes in the nuclear lamina composition during early development of Xenopus laevis. Cell 41: 191-200, 1985
21. Lehner CF, Stick R, Eppenberger M, Nigg EA: Differential expression of nuclear matrix proteins during chicken development. J Cell Biol 105: 571-687, 1987
22. Stewart C, Burke B: Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell 51: 383-392, 1987
23. Guilly M-N, Kolb J-P, Gosti F, Godeau F, Courvalin J-C: Lamins A and C are not expressed at early stages of human lymphocyte differentiation. Exp Cell Res 189: 145-148, 1990
24. Röber R-A, Weber K, Osbom M: Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: A developmental study. Development 105: 365-378, 1989
25. Oberhammer FA, Hochegger K, Froschi G: Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J Cell Biol 126: 827-837, 1994
26. Tinnemans MMJF, Lenders M-HJH, ten Velde GPM, Ramaekers FCS, Schufte B: Alterations in cytoskeletal and nuclear matrix associated proteins during apoptosis. Eur J Cell Biol 68: 35-46, 1995
27. Vandeplassche G, Hermans C, Thoné F, Borgers M: Mitochondrial hydrogen peroxide generation by NADH-oxidase activity following regional myocardial ischemia in the dog. J Mol Cell Cardiol 21: 383-392, 1989
28. Vandeplassche G, Thoné F, Borgers M: Cytochemical evidence of NADH-oxidase activity in the isolated working rabbit heart subjected to normothermic global ischemia. Histochemical J 22: 11-17, 1990
29. Hyskop PA, Hinshaw DB, Hasley WA, Schraufstafter IU, Sauerheber Spragg RG, Jackson JH, Cochrane CC: Mechanisms of oxidant-mediated cell injury. J Biol Chem 263: 1665-1675, 1988
30. Gunteski-Hamblin A-M, Song G, Walshe RA, Frenzke M, Boivin, GP, Dorn GW, Kaetzel MA, Horseman ND, Dedman JR: Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice. Am J Physiol 270: H1091-H1100, 1996
31. Borgers M, De Nollin S, Thoné F, Wouters L, Van Vaeck L, Flameng W: Distribution of calcium in a subset of chronic hibernating myocardium in man. Histochem J 25: 312-318, 1993
32. Schelbert HR: Positron emission tomography for the assessment of myocardial viability. Circulation (suppl 1) 84: 1-122-131, 1991
33. Kloner RA, Przykienk K, Patel B: Altered myocardial states. Am J Med (suppl A) 86: 14-22, 1989
34. Borgers M, Flameng W: Morphology of acute and ischemic myo- cardium in man. In: HM Piper, CJ Preusse (eds). Ischemia-reperfusion in cardiac surgery. Kluwer Academic Publishers, Boston, Dordrecht, 1993, pp 353-375
35. Mask WK, Abt-Elfaftah AS, Jessen M, Brunsting LA, Lekven J, Wechsler AS: Embryonic versus adult myocardium: Adenine nucleotide degradation during ischemia. Ann Thorac Surg 48: 109-112, 1989
36. Abt-Elfattah ASA, Murphy CE, Salter DR, Goldstein JP, Godwin CK, Wechsler AS: Age and species related differences in adenine nucleotide degradation during myocardial global ischemia. Fed Proc 45: 1039, 1986
37. Grice WN, Konishi T, Apstein CS: Resistance of neonatal myocardium to injury during normothermic and hypothermic ischemic arrest and reperfusion. Circulation 76 (suppl V): 150-155, 1987