The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells

British Journal of Pharmacology

Volumn 161, Issue 4, 2010, Pages 872-884

  Zhang, Xiao Hua ^a,c   Jin, Man Wen ^a   Sun, Hai Ying ^c   Zhang, Shetuan ^b   Li, Gui Rong ^c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

hERG channel; hK IR2.1; hK v1.5; W 7

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; CALMODULIN; CALMODULIN INHIBITOR; COMPLEMENTARY DNA; EGTAZIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.5;

ARTICLE; CALCIUM SIGNALING; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL;

CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; KV1.5 POTASSIUM CHANNEL; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SULFONAMIDES;

EID: 77957222441     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00916.x     Document Type: Article

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