Metabolic adaptation follows contractile dysfunction in the heart of obese Zucker rats fed a high-fat western diet

Obesity

Volumn 18, Issue 10, 2010, Pages 1895-1901

  Burgmaier, Mathias ^a   Sen, Shiraj ^a   Philip, Femi ^a   Wilson, Christopher R ^a   Miller III, Charles C ^a   Young, Martin E ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; MTE 1 PROTEIN, RAT; MTE-1 PROTEIN, RAT; OLEIC ACID; PALMITOYL COENZYME A HYDROLASE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; THIOL ESTER HYDROLASE; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; CALORIC INTAKE; DISEASE MODEL; DRUG EFFECT; FAT INTAKE; GENETICS; HEART CONTRACTION; HEART MUSCLE; LIPID METABOLISM; MALE; METABOLISM; OBESITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; ZUCKER RAT;

ANIMALS; DIETARY FATS; DISEASE MODELS, ANIMAL; ENERGY INTAKE; ION CHANNELS; LIPID METABOLISM; MALE; MITOCHONDRIAL PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OBESITY; OLEIC ACID; OXIDATION-REDUCTION; PALMITOYL-COA HYDROLASE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, ZUCKER; RNA, MESSENGER; THIOLESTER HYDROLASES; TRIGLYCERIDES;

RATTUS;

EID: 77957153116     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.500     Document Type: Article

References (26)

1. Bing RJ. The metabolism of the heart. Harvey Lect 1954;50:27-70.
2. Taegtmeyer H, Hems R, Krebs HA. Utilization of energy-providing substrates in the isolated working rat heart. Biochem J 1980;186:701-711.
3. Taegtmeyer H, Golfman L, Sharma S, Razeghi P, van Arsdall M. Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 2004;1015:202-213.
4. Zhou YT, Grayburn P, Karim A, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci USA 2000;97: 1784-1789.
5. Golfman LS, Wilson CR, Sharma S, et al. Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats. Am J Physiol Endocrinol Metab 2005;289:E328-E336.
6. Wilson CR, Tran MK, Salazar KL, Young ME, Taegtmeyer H. Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats. Biochem J 2007;406: 457-467.
7. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
8. Depre C, Shipley GL, Chen W, et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 1998;4:1269-1275.
9. Stavinoha MA, RaySpellicy JW, Essop MF, et al. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpharegulated gene in cardiac and skeletal muscle. Am J Physiol Endocrinol Metab 2004;287:E888-E895.
10. Chua SC Jr, White DW, Wu-Peng XS, et al. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 1996;45: 1141-1143.
11. Phillips MS, Liu Q, Hammond HA, et al. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 1996;13:18-19.
12. Sharma S, Adrogue JV, Golfman L, et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J 2004;18:1692-1700.
13. Young ME, Guthrie PH, Razeghi P, et al. Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes 2002;51:2587-2595.
14. Lei B, Lionetti V, Young ME, et al. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol 2004;36:567-576.
15. Osorio JC, Stanley WC, Linke A, et al. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation 2002;106:606-612.
16. Cohen P, Miyazaki M, Socci ND, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002;297:240-243. (Pubitemid 34761283)
17. Dobrzyn A, Dobrzyn P, Lee SH, et al. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 2005;288:E599-E607.
18. Unger RH. The physiology of cellular liporegulation. Annu Rev Physiol 2003;65:333-347.
19. Kim JK, Fillmore JJ, Chen Y, et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA 2001;98:7522-7527.
20. Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov 2004;3:340-351.
21. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fattyacid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-343.
22. Palanivel R, Eguchi M, Shuralyova I, Coe I, Sweeney G. Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes. Metabolism 2006;55:1067-1075.
23. Brandt JM, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 1998;273:23786-23792.
24. Finck BN, Kelly DP. Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol 2002;34:1249-1257.
25. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR 3rd, Young LH. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the is chemic heart. Circ Res 2005;97:872-879.
26. Sharma V, Mustafa S, Patel N, et al. Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism. Eur J Pharmacol 2009;617:113-117.