메뉴 건너뛰기




Volumn 40, Issue 10, 2010, Pages 2741-2750

A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling

Author keywords

Immunological synpase; Migration; T cell homeostasis

Indexed keywords

ACTIN; CD3 ANTIGEN; COLLAGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PHOSPHOTYROSINE; T LYMPHOCYTE RECEPTOR;

EID: 77957132681     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040575     Document Type: Article
Times cited : (5)

References (50)
  • 1
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • Bajenoff, M., Egen, J. G., Koo, L. Y., Laugier, J. P., Brau, F., Glaichenhaus, N. and Germain, R. N., Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 2006. 25: 989-1001.
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajenoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.P.4    Brau, F.5    Glaichenhaus, N.6    Germain, R.N.7
  • 2
    • 50049109579 scopus 로고    scopus 로고
    • Interstitial leukocyte migration and immune function
    • Friedl, P. and Weigelin, B., Interstitial leukocyte migration and immune function. Nat. Immunol. 2008. 9: 960-969.
    • (2008) Nat. Immunol. , vol.9 , pp. 960-969
    • Friedl, P.1    Weigelin, B.2
  • 4
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks, C. R., Freiberg, B. A., Kupfer, H., Sciaky, N. and Kupfer, A., Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998. 395: 82-86.
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 6
    • 0036696998 scopus 로고    scopus 로고
    • TCR triggering on the move: Diversity of T-cell interactions with antigen-presenting cells
    • Friedl, P. and Brocker, E. B., TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells. Immunol. Rev. 2002. 186: 83-89.
    • (2002) Immunol. Rev. , vol.186 , pp. 83-89
    • Friedl, P.1    Brocker, E.B.2
  • 7
    • 0033666324 scopus 로고    scopus 로고
    • Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential
    • Gunzer, M., Schafer, A., Borgmann, S., Grabbe, S., Zanker, K. S., Brocker, E. B., Kampgen, E. and Friedl, P., Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 2000. 13: 323-332.
    • (2000) Immunity , vol.13 , pp. 323-332
    • Gunzer, M.1    Schafer, A.2    Borgmann, S.3    Grabbe, S.4    Zanker, K.S.5    Brocker, E.B.6    Kampgen, E.7    Friedl, P.8
  • 8
    • 39449094869 scopus 로고    scopus 로고
    • Sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
    • Henrickson, S. E., Mempel, T. R., Mazo, I. B., Liu, B., Artyomov, M. N., Zheng, H., Peixoto, A. et al., T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. 2008. 9: 282-291.
    • (2008) Nat. Immunol. , vol.9 , pp. 282-291
    • Henrickson, S.E.1    Mempel, T.R.2    Mazo, I.B.3    Liu, B.4    Artyomov, M.N.5    Zheng, H.6    Peixoto, A.7    Cell, E.A.T.8
  • 9
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T. R., Henrickson, S. E. and Von Andrian, U. H., T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004. 427: 154-159.
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 11
    • 58149280838 scopus 로고    scopus 로고
    • T celldendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta
    • Tseng, S. Y., Waite, J. C., Liu, M., Vardhana, S. and Dustin, M. L., T celldendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J. Immunol. 2008. 181: 4852-4863.
    • (2008) J. Immunol. , vol.181 , pp. 4852-4863
    • Tseng, S.Y.1    Waite, J.C.2    Liu, M.3    Vardhana, S.4    Dustin, M.L.5
  • 12
    • 34249013684 scopus 로고    scopus 로고
    • Opposing effects of PKCtheta andWASp on symmetry breaking and relocation of the immunological synapse
    • Sims, T. N., Soos, T. J., Xenias, H. S., Dubin-Thaler, B., Hofman, J. M., Waite, J. C., Cameron, T. O. et al., Opposing effects of PKCtheta andWASp on symmetry breaking and relocation of the immunological synapse. Cell 2007. 129: 773-785.
    • (2007) Cell , vol.129 , pp. 773-785
    • Sims, T.N.1    Soos, T.J.2    Xenias, H.S.3    Dubin-Thaler, B.4    Hofman, J.M.5    Waite, J.C.6    Cameron, T.O.7
  • 13
    • 0742323358 scopus 로고    scopus 로고
    • T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
    • Miller, M. J., Hejazi, A. S., Wei, S. H., Cahalan, M. D. and Parker, I., T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 2004. 101: 998-1003.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 998-1003
    • Miller, M.J.1    Hejazi, A.S.2    Wei, S.H.3    Cahalan, M.D.4    Parker, I.5
  • 14
    • 58449122094 scopus 로고    scopus 로고
    • Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
    • Guimond, M., Veenstra, R. G., Grindler, D. J., Zhang, H., Cui, Y., Murphy, R. D., Kim, S. Y. et al., Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat. Immunol. 2009. 10: 149-157.
    • (2009) Nat. Immunol. , vol.10 , pp. 149-157
    • Guimond, M.1    Veenstra, R.G.2    Grindler, D.J.3    Zhang, H.4    Cui, Y.5    Murphy, R.D.6    Kim, S.Y.7
  • 15
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naïve and memory T cells
    • Surh, C. D. and Sprent, J., Homeostasis of naïve and memory T cells. Immunity 2008. 29: 848-862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 16
    • 34548748171 scopus 로고    scopus 로고
    • 'Coreceptor tuning': Cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    • Park, J. H., Adoro, S., Lucas, P. J., Sarafova, S. D., Alag, A. S., Doan, L. L., Erman, B. et al., 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat. Immunol. 2007. 8: 1049-1059.
    • (2007) Nat. Immunol. , vol.8 , pp. 1049-1059
    • Park, J.H.1    Adoro, S.2    Lucas, P.J.3    Sarafova, S.D.4    Alag, A.S.5    Doan, L.L.6    Erman, B.7
  • 17
    • 34249846231 scopus 로고    scopus 로고
    • MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo
    • Fischer, U. B., Jacovetty, E. L., Medeiros, R. B., Goudy, B. D., Zell, T., Swanson, J. B., Lorenz, E. et al., MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl. Acad. Sci. USA 2007. 104: 7181-7186.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 7181-7186
    • Fischer, U.B.1    Jacovetty, E.L.2    Medeiros, R.B.3    Goudy, B.D.4    Zell, T.5    Swanson, J.B.6    Lorenz, E.7
  • 18
    • 0038487052 scopus 로고    scopus 로고
    • Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
    • Seddon, B., Tomlinson, P. and Zamoyska, R., Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 2003. 4: 680-686.
    • (2003) Nat. Immunol. , vol.4 , pp. 680-686
    • Seddon, B.1    Tomlinson, P.2    Zamoyska, R.3
  • 19
    • 34247606456 scopus 로고    scopus 로고
    • Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function
    • De Riva, A., Bourgeois, C., Kassiotis, G. and Stockinger, B., Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function. J. Immunol. 2007. 178: 5488-5495.
    • (2007) J. Immunol. , vol.178 , pp. 5488-5495
    • De Riva, A.1    Bourgeois, C.2    Kassiotis, G.3    Stockinger, B.4
  • 20
    • 0036200851 scopus 로고    scopus 로고
    • Impairment of immunological memory in the absence of MHC despite survival of memory T cells
    • Kassiotis, G., Garcia, S., Simpson, E. and Stockinger, B., Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat. Immunol. 2002. 3: 244-250.
    • (2002) Nat. Immunol. , vol.3 , pp. 244-250
    • Kassiotis, G.1    Garcia, S.2    Simpson, E.3    Stockinger, B.4
  • 21
    • 0034769286 scopus 로고    scopus 로고
    • Functional antigen-independent synapses formed between T cells and dendritic cells
    • Revy, P., Sospedra, M., Barbour, B. and Trautmann, A., Functional antigen-independent synapses formed between T cells and dendritic cells. Nat. Immunol. 2001. 2: 925-931.
    • (2001) Nat. Immunol. , vol.2 , pp. 925-931
    • Revy, P.1    Sospedra, M.2    Barbour, B.3    Trautmann, A.4
  • 22
    • 26044456755 scopus 로고    scopus 로고
    • Multiple survival signals are delivered by dendritic cells to naïve CD4+ T cells
    • Feuillet, V., Lucas, B., Di Santo, J. P., Bismuth, G. and Trautmann, A., Multiple survival signals are delivered by dendritic cells to naïve CD4+ T cells. Eur. J. Immunol. 2005. 35: 2563-2572.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2563-2572
    • Feuillet, V.1    Lucas, B.2    Di Santo, J.P.3    Bismuth, G.4    Trautmann, A.5
  • 23
    • 33846908076 scopus 로고    scopus 로고
    • Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation
    • Meraner, P., Horejsi, V., Wolpl, A., Fischer, G. F., Stingl, G. and Maurer, D., Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation. J. Immunol. 2007. 178: 2262-2271.
    • (2007) J. Immunol. , vol.178 , pp. 2262-2271
    • Meraner, P.1    Horejsi, V.2    Wolpl, A.3    Fischer, G.F.4    Stingl, G.5    Maurer, D.6
  • 24
    • 2142847315 scopus 로고    scopus 로고
    • Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computerassisted tracking
    • Friedl, P. and Brocker, E. B., Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computerassisted tracking. Methods. Mol. Biol. 2004. 239: 77-90.
    • (2004) Methods. Mol. Biol. , vol.239 , pp. 77-90
    • Friedl, P.1    Brocker, E.B.2
  • 25
    • 16844386089 scopus 로고    scopus 로고
    • Regulation of mature T cell homeostasis
    • Surh, C. D. and Sprent, J., Regulation of mature T cell homeostasis. Semin. Immunol. 2005. 17: 183-191.
    • (2005) Semin. Immunol. , vol.17 , pp. 183-191
    • Surh, C.D.1    Sprent, J.2
  • 26
    • 0030939803 scopus 로고    scopus 로고
    • ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes
    • del Pozo, M. A., Cabanas, C., Montoya, M. C., Ager, A., Sanchez-Mateos, P. and Sanchez-Madrid, F., ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes. J. Cell Biol. 1997. 137: 493-508.
    • (1997) J. Cell Biol. , vol.137 , pp. 493-508
    • Del Pozo, M.A.1    Cabanas, C.2    Montoya, M.C.3    Ager, A.4    Sanchez-Mateos, P.5    Sanchez-Madrid, F.6
  • 28
    • 33845614097 scopus 로고    scopus 로고
    • Rafting with cholera toxin: Endocytosis and trafficking from plasma membrane to ER
    • Chinnapen, D. J., Chinnapen, H., Saslowsky, D. and Lencer, W. I., Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol. Lett. 2007. 266: 129-137.
    • (2007) FEMS Microbiol. Lett. , vol.266 , pp. 129-137
    • Chinnapen, D.J.1    Chinnapen, H.2    Saslowsky, D.3    Lencer, W.I.4
  • 29
    • 0142242134 scopus 로고    scopus 로고
    • Cutting edge: Dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent
    • Al-Alwan, M. M., Liwski, R. S., Haeryfar, S. M., Baldridge, W. H., Hoskin, D. W., Rowden, G. and West, K. A., Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J. Immunol. 2003. 171: 4479-4483.
    • (2003) J. Immunol. , vol.171 , pp. 4479-4483
    • Al-Alwan, M.M.1    Liwski, R.S.2    Haeryfar, S.M.3    Baldridge, W.H.4    Hoskin, D.W.5    Rowden, G.6    West, K.A.7
  • 30
    • 0026044013 scopus 로고
    • Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice
    • Grusby, M. J., Johnson, R. S., Papaioannou, V. E. and Glimcher, L. H., Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 1991. 253: 1417-1420.
    • (1991) Science , vol.253 , pp. 1417-1420
    • Grusby, M.J.1    Johnson, R.S.2    Papaioannou, V.E.3    Glimcher, L.H.4
  • 31
    • 4644324248 scopus 로고    scopus 로고
    • Diversity in immune-cell interactions: States and functions of the immunological synapse
    • Friedl, P. and Storim, J., Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol. 2004. 14: 557-567.
    • (2004) Trends Cell Biol. , vol.14 , pp. 557-567
    • Friedl, P.1    Storim, J.2
  • 32
    • 0028961573 scopus 로고
    • Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
    • Valitutti, S., Dessing, M., Aktories, K., Gallati, H. and Lanzavecchia, A., Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 1995. 181: 577-584.
    • (1995) J. Exp. Med. , vol.181 , pp. 577-584
    • Valitutti, S.1    Dessing, M.2    Aktories, K.3    Gallati, H.4    Lanzavecchia, A.5
  • 34
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • Varma, R., Campi, G., Yokosuka, T., Saito, T. and Dustin, M. L., T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006. 25: 117-127.
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 35
    • 0037154747 scopus 로고    scopus 로고
    • T cell receptor signaling precedes immunological synapse formation
    • Lee, K. H., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M. and Shaw, A. S., T cell receptor signaling precedes immunological synapse formation. Science 2002. 295: 1539-1542.
    • (2002) Science , vol.295 , pp. 1539-1542
    • Lee, K.H.1    Holdorf, A.D.2    Dustin, M.L.3    Chan, A.C.4    Allen, P.M.5    Shaw, A.S.6
  • 37
    • 0032568580 scopus 로고    scopus 로고
    • Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
    • Wulfing, C., Sjaastad, M. D. and Davis, M. M., Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc. Natl. Acad. Sci. USA 1998. 95: 6302-6307.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6302-6307
    • Wulfing, C.1    Sjaastad, M.D.2    Davis, M.M.3
  • 38
    • 33846031421 scopus 로고    scopus 로고
    • The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation
    • Suzuki, J., Yamasaki, S., Wu, J., Koretzky, G. A. and Saito, T., The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood 2007. 109: 168-175.
    • (2007) Blood , vol.109 , pp. 168-175
    • Suzuki, J.1    Yamasaki, S.2    Wu, J.3    Koretzky, G.A.4    Saito, T.5
  • 39
    • 22244438250 scopus 로고    scopus 로고
    • A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
    • Smith, A., Carrasco, Y. R., Stanley, P., Kieffer, N., Batista, F. D. and Hogg, N., A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J. Cell Biol. 2005. 170: 141-151.
    • (2005) J. Cell Biol. , vol.170 , pp. 141-151
    • Smith, A.1    Carrasco, Y.R.2    Stanley, P.3    Kieffer, N.4    Batista, F.D.5    Hogg, N.6
  • 40
    • 36248995106 scopus 로고    scopus 로고
    • Rho/ROCK and myosin II control the polarized distribution of endocytic clathrin structures at the uropod of moving T lymphocytes
    • Samaniego, R., Sanchez-Martin, L., Estecha, A. and Sanchez-Mateos, P., Rho/ROCK and myosin II control the polarized distribution of endocytic clathrin structures at the uropod of moving T lymphocytes. J. Cell Sci. 2007. 120: 3534-3543.
    • (2007) J. Cell Sci. , vol.120 , pp. 3534-3543
    • Samaniego, R.1    Sanchez-Martin, L.2    Estecha, A.3    Sanchez-Mateos, P.4
  • 41
    • 2442472174 scopus 로고    scopus 로고
    • CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism
    • Tong, J., Allenspach, E. J., Takahashi, S. M., Mody, P. D., Park, C., Burkhardt, J. K. and Sperling, A. I., CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. J. Exp. Med. 2004. 199: 1277-1283.
    • (2004) J. Exp. Med. , vol.199 , pp. 1277-1283
    • Tong, J.1    Allenspach, E.J.2    Takahashi, S.M.3    Mody, P.D.4    Park, C.5    Burkhardt, J.K.6    Sperling, A.I.7
  • 42
    • 0031903617 scopus 로고    scopus 로고
    • CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
    • Friedl, P., Entschladen, F., Conrad, C., Niggemann, B. and Zanker, K. S., CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion. Eur. J. Immunol. 1998. 28: 2331-2343.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2331-2343
    • Friedl, P.1    Entschladen, F.2    Conrad, C.3    Niggemann, B.4    Zanker, K.S.5
  • 45
    • 5444229324 scopus 로고    scopus 로고
    • Imaging the single cell dynamics of CD41 T cell activation by dendritic cells in lymph nodes
    • Miller, M. J., Safrina, O., Parker, I. and Cahalan, M. D., Imaging the single cell dynamics of CD41 T cell activation by dendritic cells in lymph nodes. J. Exp. Med. 2004. 200: 847-856.
    • (2004) J. Exp. Med. , vol.200 , pp. 847-856
    • Miller, M.J.1    Safrina, O.2    Parker, I.3    Cahalan, M.D.4
  • 46
    • 77649255627 scopus 로고    scopus 로고
    • Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes
    • Azar, G. A., Lemaitre, F., Robey, E. A. and Bousso, P., Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc. Natl. Acad. Sci. USA 2010. 107: 3675-3680.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3675-3680
    • Azar, G.A.1    Lemaitre, F.2    Robey, E.A.3    Bousso, P.4
  • 47
    • 0037036140 scopus 로고    scopus 로고
    • Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy
    • Bousso, P., Bhakta, N. R., Lewis, R. S. and Robey, E., Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 2002. 296: 1876-1880.
    • (2002) Science , vol.296 , pp. 1876-1880
    • Bousso, P.1    Bhakta, N.R.2    Lewis, R.S.3    Robey, E.4
  • 48
    • 34547135943 scopus 로고    scopus 로고
    • Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
    • Skokos, D., Shakhar, G., Varma, R., Waite, J. C., Cameron, T. O., Lindquist, R. L., Schwickert, T. et al., Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat. Immunol. 2007. 8: 835-844.
    • (2007) Nat. Immunol. , vol.8 , pp. 835-844
    • Skokos, D.1    Shakhar, G.2    Varma, R.3    Waite, J.C.4    Cameron, T.O.5    Lindquist, R.L.6    Schwickert, T.7
  • 49
    • 27144458078 scopus 로고    scopus 로고
    • Cutting edge: Cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells
    • O'Keefe, J. P. and Gajewski, T. F., Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells. J. Immunol. 2005. 175: 5581-5585.
    • (2005) J. Immunol. , vol.175 , pp. 5581-5585
    • O'Keefe, J.P.1    Gajewski, T.F.2
  • 50
    • 0020589504 scopus 로고
    • Mapping of antigenic and functional epitopes on the alpha- And beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1
    • Sanchez-Madrid, F., Simon, P., Thompson, S. and Springer, T. A., Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J. Exp. Med. 1983. 158: 586-602.
    • (1983) J. Exp. Med. , vol.158 , pp. 586-602
    • Sanchez-Madrid, F.1    Simon, P.2    Thompson, S.3    Springer, T.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.