CD43 Regulation of T Cell Activation Is Not through Steric Inhibition of T Cell-APC Interactions but through an Intracellular Mechanism

Journal of Experimental Medicine

Volumn 199, Issue 9, 2004, Pages 1277-1283

  Tong, Jiankun ^a   Allenspach, Eric J ^a   Takahashi, Stephenie M ^a   Mody, Purvi D ^a   Park, Chan ^a   Burkhardt, Janis K ^b   Sperling, Anne I ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Section of Pulmonary and Critical Care   (United States)

Author keywords

Adhesion; CD25; CD43; Proliferation; SMAC

Indexed keywords

EZRIN; GLYCOSYLPHOSPHATIDYLINOSITOL; LEUKOSIALIN; MOESIN; RADIXIN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOLOGICAL SYNAPSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOCHEMISTRY; SYNAPSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD43; CELL COMMUNICATION; FLUORESCENT ANTIBODY TECHNIQUE; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; SIALOGLYCOPROTEINS; T-LYMPHOCYTES;

EID: 2442472174     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021602     Document Type: Article

References (27)

1. Remold-O'Donnell, E., D.M. Kenney, R. Parkman, L. Cairns, B. Savage, and F.S. Rosen. 1984. Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome. J. Exp. Med. 159:1705-1723.
2. Axelsson, B., and P. Perlmann. 1989. Persistent superphosphorylation of leukosialin (CD43) in activated T cells and in tumour cell lines. Scand. J. Immunol. 30:539-547.
3. Remold-O'Donnell, E., and F.S. Rosen. 1990. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodefic. Rev. 2:151-174.
4. Cyster, J.G., D.M. Shotton, and A.F. Williams. 1991. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 10:893-902.
5. Manjunath, N., R.S. Johnson, D.E. Staunton, R. Pasqualini, and B. Ardman. 1993. Targeted disruption of CD43 gene enhances T lymphocyte adhesion. J. Immunol. 151:1528-1534.
6. Cyster, J., C. Somoza, N. Killeen, and A.F. Williams. 1990. Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur. J. Immunol. 20:875-881.
7. Ostberg, J.R., R.K. Barth, and J.G. Frelinger. 1998. The Roman god Janus: a paradigm for the function of CD43. Immunol. Today. 19:546-550.
8. Manjunath, N., M. Correa, M. Ardman, and B. Ardman. 1995. Negative regulation of T-cell adhesion and activation by CD43. Nature. 377:535-538.
9. Walker, J., and J.M. Green. 1999. Structural requirements for CD43 function. J. Immunol. 162:4109-4114.
10. Thurman, E.C., J. Walker, S. Jayaraman, N. Manjunath, B. Ardman, and J.M. Green. 1998. Regulation of in vitro and in vivo T cell activation by CD43. Int. Immunol. 10:691-701.
11. Sperling, A.I., J.M. Green, R.L. Mosley, P.L. Smith, R.J. Di-Paolo, J.R. Klein, J.A. Bluestone, and C.B. Thompson. 1995. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182:139-146.
12. Onami, T.M., L.E. Harrington, M.A. Williams, M. Galvan, C.P. Larsen, T.C. Pearson, N. Manjunath, L.G. Baum, B.D. Pearce, and R. Ahmed. 2002. Dynamic regulation of T cell immunity by CD43. J. Immunol. 168:6022-6031.
13. Sperling, A.I., J.R. Sedy, N. Manjunath, A. Kupfer, B. Ardman, and J.K. Burkhardt. 1998. TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. J. Immunol. 161:6459-6462.
14. Allenspach, E.J., P. Cullinan, J. Tong, Q. Tang, A.G. Tesciuba, J.L. Cannon, S.M. Takahashi, R. Morgan, J.K. Burkhardt, and A.I. Sperling. 2001. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 15:739-750.
15. Delon, J., K. Kaibuchi, and R.N. Germain. 2001. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity. 15:691-701.
16. Roumier, A., J.C. Olivo-Marin, M. Arpin, F. Michel, M. Martin, P. Mangeat, O. Acuto, A. Dautry-Varsat, and A. Alcover. 2001. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity. 15:715-728.
17. Abe, R., P. Vandenberghe, N. Craighead, D.S. Smoot, K.P. Lee, and C.H. June. 1995. Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J. Immunol. 154:985-997.
18. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
19. Shaw, A.S., and M.L. Dustin. 1997. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity. 6:361-369.
20. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe. 1997. The architecture and interactions of leukocyte surface molecules. In The Leukocyte Antigen Facts Book. Academic Press, New York. 101-131.
21. Janes, P.W., S.C. Ley, and A.I. Magee. 1999. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147:447-461.
22. Savage, N.D., S.L. Kimzey, S.K. Bromley, K.G. Johnson, M.L. Dustin, and J.M. Green. 2002. Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J. Immunol. 168:3740-3746.
23. Chatila, T.A., and R.S. Geha. 1988. Phosphorylation of T cell membrane proteins by activators of protein kinase C. J. Immunol. 140:4308-4314.
24. van den Berg, T.K., D. Nath, H.J. Ziltener, D. Vestweber, M. Fukuda, I. van Die, and P.R. Crocker. 2001. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J. Immunol. 166:3637-3640.
25. Todeschini, A.R., M.P. Nunes, R.S. Pires, M.F. Lopes, J.O. Previato, L. Mendonca-Previato, and G.A. DosReis. 2002. Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J. Immunol. 168:5192-5198.
26. Schmid, K., M.A. Hediger, R. Brossmer, J.H. Collins, H. Haupt, T. Marti, G.D. Offner, J. Schaller, K. Takagaki, M.T. Walsh, et al. 1992. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc. Natl. Acad. Sci. USA. 89:663-667.
27. Fratazzi, C., N. Manjunath, R.D. Arbeit, C. Carini, T.A. Gerken, B. Ardman, E. Remold-O'Donnell, and H.G. Remold. 2000. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J. Exp. Med. 192:183-192.