A new pyrimidine-specific reporter gene: A mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs

Journal of Nuclear Medicine

Volumn 51, Issue 9, 2010, Pages 1395-1403

  Likar, Yury ^a   Zurita, Juan ^a   Dobrenkov, Konstantin ^a   Shenker, Larissa ^a   Cai, Shangde ^a   Neschadim, Anton ^b   Medin, Jeffrey A ^b,c   Sadelain, Michel ^a   Hricak, Hedvig ^a   Ponomarev, Vladimir ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

dCK; FEAU; FHBG; Molecular imaging; PET; Reporter gene

Indexed keywords

5 ETHYL 2' FLUOROURACIL ARABINOSIDE; 5 ETHYL 2' FLUOROURACIL ARABINOSIDE F 18; 9 [4 FLUORO 3 (HYDROXYMETHYL)BUTYL]GUANINE F 18; ACICLOVIR; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBON 14; CYTARABINE; CYTOTOXIC AGENT; DEOXYCYTIDINE KINASE; GANCICLOVIR; GEMCITABINE; PENCICLOVIR; PYRIMIDINE; RADIOPHARMACEUTICAL AGENT; TRITIUM; UNCLASSIFIED DRUG; 2' FLUORO 5 ETHYLARABINOSYLURACIL; 2'-FLUORO-5-ETHYLARABINOSYLURACIL; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; PRODRUG; TRACER; URACIL ARABINOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SENSITIVITY; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUTANT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; SUICIDE GENE; ANIMAL; CELL STRAIN 3T3; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; ENZYME SPECIFICITY; GENETICS; LYMPHOCYTE; METABOLISM; MUTATION; PHOSPHORYLATION; TUMOR CELL LINE;

ACYCLOVIR; ANIMALS; ANTINEOPLASTIC AGENTS; ARABINOFURANOSYLURACIL; CELL LINE, TUMOR; DEOXYCYTIDINE KINASE; FLUORINE RADIOISOTOPES; GENES, REPORTER; HUMANS; LYMPHOCYTES; MICE; MUTATION; NIH 3T3 CELLS; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PRODRUGS; RADIOACTIVE TRACERS; SUBSTRATE SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; TRANSDUCTION, GENETIC;

EID: 77957087452     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.074344     Document Type: Article

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