메뉴 건너뛰기




Volumn 17, Issue 2, 2005, Pages 180-186

The role of tumor stroma in the interaction between tumor and immune system

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD8 ANTIGEN; CYTOKINE; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; PERFORIN;

EID: 14844297325     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.01.008     Document Type: Review
Times cited : (164)

References (57)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0035253742 scopus 로고    scopus 로고
    • Know thy neighbor: Stromal cells can contribute oncogenic signals
    • T.D. Tlsty, and P.W. Hein Know thy neighbor: stromal cells can contribute oncogenic signals Curr Opin Genet Dev 11 2001 54 59
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 54-59
    • Tlsty, T.D.1    Hein, P.W.2
  • 4
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • B. Elenbaas, and R.A. Weinberg Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation Exp Cell Res 264 2001 169 184
    • (2001) Exp Cell Res , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 5
    • 0035495401 scopus 로고    scopus 로고
    • Putting tumours in context
    • M. Bissel, and D. Radisky Putting tumours in context Nat Rev Cancer 1 2001 46 54
    • (2001) Nat Rev Cancer , vol.1 , pp. 46-54
    • Bissel, M.1    Radisky, D.2
  • 6
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • B. Wiseman, and Z. Werb Stromal effects on mammary gland development and breast cancer Science 296 2002 1046 1049
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.1    Werb, Z.2
  • 7
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • N.A. Bhowmick, A. Chytil, D. Plieth, A.E. Gorska, N. Dumont, S. Shappell, M.K. Washington, E.G. Neilson, and H.L. Moses TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia Science 303 2004 848 851 By conditional Cre/Lox KO technology, this study shows that mice whose fibroblasts cannot respond to TGF-β develop epithelial carcinomas.
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3    Gorska, A.E.4    Dumont, N.5    Shappell, S.6    Washington, M.K.7    Neilson, E.G.8    Moses, H.L.9
  • 8
    • 0025974725 scopus 로고
    • Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes
    • R.J. Barth Jr., J.J. Mule, P.J. Spiess, and S.A. Rosenberg Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes J Exp Med 173 1991 647 658
    • (1991) J Exp Med , vol.173 , pp. 647-658
    • Barth Jr., R.J.1    Mule, J.J.2    Spiess, P.J.3    Rosenberg, S.A.4
  • 10
    • 0037375553 scopus 로고    scopus 로고
    • The role of IFNγ in tumor transplantation immunity and inhibition of chemical carcinogenesis
    • T. Blankenstein, and Z. Qin The role of IFNγ in tumor transplantation immunity and inhibition of chemical carcinogenesis Curr Opin Immunol 15 2003 148 154 This review summarizes data showing that IFN-γ contributes to the rejection of transplanted tumors and to the inhibition of methylcholanthrene-induced fibrosarcomas by different mechanisms.
    • (2003) Curr Opin Immunol , vol.15 , pp. 148-154
    • Blankenstein, T.1    Qin, Z.2
  • 11
    • 0033847207 scopus 로고    scopus 로고
    • Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature
    • B. Stoelker, B. Ruhland, T. Hehlgans, H. Bluethmann, T. Luther, and D.N. Männel Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature Am J Pathol 156 2000 1171 1176
    • (2000) Am J Pathol , vol.156 , pp. 1171-1176
    • Stoelker, B.1    Ruhland, B.2    Hehlgans, T.3    Bluethmann, H.4    Luther, T.5    Männel, D.N.6
  • 13
    • 0032853311 scopus 로고    scopus 로고
    • Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L)
    • H. Winter, H.M. Hu, W.J. Urba, and B.A. Fox Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L) J Immunol 163 1999 4462 4472
    • (1999) J Immunol , vol.163 , pp. 4462-4472
    • Winter, H.1    Hu, H.M.2    Urba, W.J.3    Fox, B.A.4
  • 14
    • 0035877073 scopus 로고    scopus 로고
    • Immunotherapy of melanoma: A dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy
    • H. Winter, H.M. Hu, K. McClain, W.J. Urba, and B.A. Fox Immunotherapy of melanoma: a dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy J Immunol 166 2001 7370 7380
    • (2001) J Immunol , vol.166 , pp. 7370-7380
    • Winter, H.1    Hu, H.M.2    McClain, K.3    Urba, W.J.4    Fox, B.A.5
  • 15
    • 0033662405 scopus 로고    scopus 로고
    • + T cell mediated tumor immunity involves inhibition of angiogenesis which is dependent on IFNγ receptor expression by non-hematopoietic cells
    • + T cell mediated tumor immunity involves inhibition of angiogenesis which is dependent on IFNγ receptor expression by non-hematopoietic cells Immunity 12 2000 677 686
    • (2000) Immunity , vol.12 , pp. 677-686
    • Qin, Z.1    Blankenstein, Th.2
  • 16
    • 0033830050 scopus 로고    scopus 로고
    • Differential requirement of perforin and IFN-gamma in CD8 T cell-mediated immune responses against B16.F10 melanoma cells expressing a viral antigen
    • A. Prevost-Blondel, M. Neuenhahn, M. Rawiel, and H. Pircher Differential requirement of perforin and IFN-gamma in CD8 T cell-mediated immune responses against B16.F10 melanoma cells expressing a viral antigen Eur J Immunol 30 2000 2507 2515
    • (2000) Eur J Immunol , vol.30 , pp. 2507-2515
    • Prevost-Blondel, A.1    Neuenhahn, M.2    Rawiel, M.3    Pircher, H.4
  • 17
    • 0034672005 scopus 로고    scopus 로고
    • T cell-mediated tumor rejection displays diverse dependence upon perforin and IFN-gamma mechanisms that cannot be predicted from in vitro T cell characteristics
    • L. Peng, J.C. Krauss, G.E. Plautz, S. Mukai, S. Shu, and P.A. Cohen T cell-mediated tumor rejection displays diverse dependence upon perforin and IFN-gamma mechanisms that cannot be predicted from in vitro T cell characteristics J Immunol 165 2000 7116 7124
    • (2000) J Immunol , vol.165 , pp. 7116-7124
    • Peng, L.1    Krauss, J.C.2    Plautz, G.E.3    Mukai, S.4    Shu, S.5    Cohen, P.A.6
  • 18
    • 0035803463 scopus 로고    scopus 로고
    • Tumor rejection by disturbing tumor stroma cell interactions
    • S. Ibe, Z. Qin, T. Schüler, S. Preiss, and Th. Blankenstein Tumor rejection by disturbing tumor stroma cell interactions J Exp Med 194 2001 1549 1560
    • (2001) J Exp Med , vol.194 , pp. 1549-1560
    • Ibe, S.1    Qin, Z.2    Schüler, T.3    Preiss, S.4    Blankenstein, Th.5
  • 20
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
    • A. van Elsas, Sutmuller RPM, A.A. Hurwitz, J. Ziskin, J. Villasenor, J.P. Medema, W.W. Overwijk, N.P. Restifo, C.J.M. Melief, R. Offringa, and J.P. Allison Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy J Exp Med 194 2001 481 489
    • (2001) J Exp Med , vol.194 , pp. 481-489
    • Van Elsas, A.1    Sutmuller, R.P.M.2    Hurwitz, A.A.3    Ziskin, J.4    Villasenor, J.5    Medema, J.P.6    Overwijk, W.W.7    Restifo, N.P.8    Melief, C.J.M.9    Offringa, R.10    Allison, J.P.11
  • 21
    • 0036533647 scopus 로고    scopus 로고
    • Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin
    • N. Seki, A.D. Brooks, C.R. Carter, T.C. Back, E.M. Parsoneault, M.J. Smyth, R.H. Wiltrout, and T.J. Sayers Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin J Immunol 168 2002 3484 3492
    • (2002) J Immunol , vol.168 , pp. 3484-3492
    • Seki, N.1    Brooks, A.D.2    Carter, C.R.3    Back, T.C.4    Parsoneault, E.M.5    Smyth, M.J.6    Wiltrout, R.H.7    Sayers, T.J.8
  • 23
    • 0037406702 scopus 로고    scopus 로고
    • + effector T cells reject tumors by direct antigen recognition but indirect action on host cells
    • + effector T cells 'see' antigen on the tumor cells and produce IFN-γ, which acts on the host, probably on tumor stromal cells.
    • (2003) J Immunol , vol.170 , pp. 4427-4431
    • Schüler, T.1    Blankenstein, Th.2
  • 24
    • 0037442129 scopus 로고    scopus 로고
    • TNF plays an essential role in tumor regression after adoptive transfer of perforin/IFN-gamma double knockout effector T cells
    • C.H. Poehlein, H.M. Hu, J. Yamada, I. Assmann, W.G. Alvord, W.J. Urba, and B.A. Fox TNF plays an essential role in tumor regression after adoptive transfer of perforin/IFN-gamma double knockout effector T cells J Immunol 170 2003 2004 2013 T cells which are doubly deficient in perforin and IFN-γ are unable to reject tumors in adoptive T cell transfer models. If large numbers of T cells are transferred, the immune deficiency is obviated.
    • (2003) J Immunol , vol.170 , pp. 2004-2013
    • Poehlein, C.H.1    Hu, H.M.2    Yamada, J.3    Assmann, I.4    Alvord, W.G.5    Urba, W.J.6    Fox, B.A.7
  • 26
    • 2342485077 scopus 로고    scopus 로고
    • Bystander elimination of antigen loss variants in established tumors
    • + effector T cells. Tumor rejection requires large amounts of tumor-derived antigen.
    • (2004) Nat Med , vol.10 , pp. 294-298
    • Spiotto, M.1    Rowley, D.A.2    Schreiber, H.3
  • 28
    • 4043174820 scopus 로고    scopus 로고
    • Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-γ and B cell dependent
    • P. Nanni, L. Landuzzi, G. Nicoletti, C. De Giovanni, I. Rossi, S. Croci, A. Astolfi, M. Iezzi, E. Di Carlo, and P. Musiani Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-γ and B cell dependent J Immunol 173 2004 2288 2296 Successful vaccination of cancer-prone Her2 transgenic mice requires IFN-γ and involves antiangiogenesis. The source of IFN-γ is not yet clear.
    • (2004) J Immunol , vol.173 , pp. 2288-2296
    • Nanni, P.1    Landuzzi, L.2    Nicoletti, G.3    De Giovanni, C.4    Rossi, I.5    Croci, S.6    Astolfi, A.7    Iezzi, M.8    Di Carlo, E.9    Musiani, P.10
  • 29
    • 3242771187 scopus 로고    scopus 로고
    • The rate of the CD8- dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis
    • J.A. Hollenbough, J. Reome, M. Dobrzanski, and R.W. Dutton The rate of the CD8- dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis J Immunol 173 2004 1738 1743 Adoptively transferred CD8+ effector T cells with multiple cytolytic defects can reject tumors but IFN-γ is required.
    • (2004) J Immunol , vol.173 , pp. 1738-1743
    • Hollenbough, J.A.1    Reome, J.2    Dobrzanski, M.3    Dutton, R.W.4
  • 30
    • 1342282158 scopus 로고    scopus 로고
    • Long-term suppression of tumor growth by TNF requires a Stat1- and IFN response factor 1-dependent IFNγ pathway but not IL-12 or IL-18
    • T.H. Wu, C.N. Pabin, Z. Qin, Th. Blankenstein, M. Philip, J. Dignam, K. Schreiber, and H. Schreiber Long-term suppression of tumor growth by TNF requires a Stat1- and IFN response factor 1-dependent IFNγ pathway but not IL-12 or IL-18 J Immunol 172 2004 3243 3251 Rejection of TNF-α-secreting tumors requires TNF receptor expression on non-bone-marrow-derived tumor stromal cells, probably to inhibit angiogenesis. Surprisingly, IFN-γ KO mice cannot reject the TNF-α-secreting tumors, but highly effective anti-IFN-γ mAbs cannot restore tumor growth.
    • (2004) J Immunol , vol.172 , pp. 3243-3251
    • Wu, T.H.1    Pabin, C.N.2    Qin, Z.3    Blankenstein, Th.4    Philip, M.5    Dignam, J.6    Schreiber, K.7    Schreiber, H.8
  • 33
    • 2442452552 scopus 로고    scopus 로고
    • CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
    • + T cells fail to reject established tumors, except in the case of tumor-bearing mice which were pretreated with CpG oligonucleotides. The authors argue that the pretreatment enables efficient T cell infiltration.
    • (2004) J Immunol , vol.172 , pp. 5861-5869
    • Garbi, N.1    Arnold, B.2    Gordon, S.3    Hämmerling, G.J.4    Ganss, R.5
  • 34
    • 0036911269 scopus 로고    scopus 로고
    • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
    • M.T. Spiotto, P. Yu, D.A. Rowley, M.I. Nishimura, S.C. Meredith, T.F. Gajewski, Y.X. Fu, and H. Schreiber Increasing tumor antigen expression overcomes "Ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells Immunity 17 2002 737 747
    • (2002) Immunity , vol.17 , pp. 737-747
    • Spiotto, M.T.1    Yu, P.2    Rowley, D.A.3    Nishimura, M.I.4    Meredith, S.C.5    Gajewski, T.F.6    Fu, Y.X.7    Schreiber, H.8
  • 36
    • 0034650432 scopus 로고    scopus 로고
    • Type 1 and type 2 CD8+ effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumor
    • M.J. Dobrzanski, J.B. Reome, and R.W. Dutton Type 1 and type 2 CD8+ effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumor J Immunol 164 2000 916 925
    • (2000) J Immunol , vol.164 , pp. 916-925
    • Dobrzanski, M.J.1    Reome, J.B.2    Dutton, R.W.3
  • 37
    • 0035399599 scopus 로고    scopus 로고
    • Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection
    • M.J. Dobrzanski, J.B. Reome, and R.W. Dutton Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection J Immunol 167 2001 424 434
    • (2001) J Immunol , vol.167 , pp. 424-434
    • Dobrzanski, M.J.1    Reome, J.B.2    Dutton, R.W.3
  • 38
    • 0037415596 scopus 로고    scopus 로고
    • Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: An eotaxin and STAT6-dependent process
    • J. Mattes, M. Hulett, W. Xie, S. Hogan, M.E. Rothenberg, P. Foster, and C. Parish Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process J Exp Med 197 2003 387 393
    • (2003) J Exp Med , vol.197 , pp. 387-393
    • Mattes, J.1    Hulett, M.2    Xie, W.3    Hogan, S.4    Rothenberg, M.E.5    Foster, P.6    Parish, C.7
  • 39
    • 0024502120 scopus 로고
    • Murine interleukin-4 displays potent anti-tumor activity in vivo
    • R.I. Tepper, P.K. Pattengale, and P. Leder Murine interleukin-4 displays potent anti-tumor activity in vivo Cell 57 1989 503 512
    • (1989) Cell , vol.57 , pp. 503-512
    • Tepper, R.I.1    Pattengale, P.K.2    Leder, P.3
  • 40
    • 0027407938 scopus 로고
    • Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma
    • H. Hock, M. Dorsch, U. Kunzendorf, Z. Qin, T. Diamantstein, and T. Blankenstein Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma Proc Natl Acad Sci USA 90 1993 2774 2778
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2774-2778
    • Hock, H.1    Dorsch, M.2    Kunzendorf, U.3    Qin, Z.4    Diamantstein, T.5    Blankenstein, T.6
  • 41
    • 0028224194 scopus 로고
    • Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis
    • G.D. Sempowski, M.P. Beckmann, S. Derdak, and R.P. Phipps Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis J Immunol 152 1994 3606 3614
    • (1994) J Immunol , vol.152 , pp. 3606-3614
    • Sempowski, G.D.1    Beckmann, M.P.2    Derdak, S.3    Phipps, R.P.4
  • 42
    • 0037133611 scopus 로고    scopus 로고
    • Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts
    • T. Kodera, T.L. McGaha, R. Phelps, W.E. Paul, and C.A. Bona Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts Proc Natl Acad Sci USA 99 2002 3800 3805
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3800-3805
    • Kodera, T.1    McGaha, T.L.2    Phelps, R.3    Paul, W.E.4    Bona, C.A.5
  • 44
    • 0027482399 scopus 로고
    • Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts
    • A. Noel, M.C. De Pauw-Gillet, G. Purnell, B. Nusgens, C.M. Lapiere, and J.M. Foidart Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts Br J Cancer 68 1993 909 915
    • (1993) Br J Cancer , vol.68 , pp. 909-915
    • Noel, A.1    De Pauw-Gillet, M.C.2    Purnell, G.3    Nusgens, B.4    Lapiere, C.M.5    Foidart, J.M.6
  • 45
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • A.F. Olumi, G.D. Grossfeld, S.W. Hayward, P.R. Carroll, T.D. Tlsty, and G.R. Cunha Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium Cancer Res 59 1999 5002 5011
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 46
    • 0344585901 scopus 로고    scopus 로고
    • Tumor rejection by modulation of tumor stroma fibroblasts
    • T. Schüler, S. Körnig, and Th. Blankenstein Tumor rejection by modulation of tumor stroma fibroblasts J Exp Med 198 2003 1487 1493 IL-4 secreting tumors are rejected by modulation of tumor-associated fibroblasts. It is suggested that in the presence of IL-4 the fibroblasts differentiate to a phenotype that is not able to participate in tumor-induced angiogenesis.
    • (2003) J Exp Med , vol.198 , pp. 1487-1493
    • Schüler, T.1    Körnig, S.2    Blankenstein, Th.3
  • 47
    • 0030741044 scopus 로고    scopus 로고
    • The paracrine role of tumour-derived mIL-4 on tumour-associated endothelium
    • M. Saleh, I.D. Davis, and A.F. Wilks The paracrine role of tumour-derived mIL-4 on tumour-associated endothelium Int J Cancer 72 1997 664 672
    • (1997) Int J Cancer , vol.72 , pp. 664-672
    • Saleh, M.1    Davis, I.D.2    Wilks, A.F.3
  • 50
    • 0021684729 scopus 로고
    • Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages
    • P.J. Polverini, and J. Leibovich Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages Lab Invest 51 1984 635 642
    • (1984) Lab Invest , vol.51 , pp. 635-642
    • Polverini, P.J.1    Leibovich, J.2
  • 51
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • E.Y. Lin, A.V. Nguyen, R.G. Russell, and J.W. Pollard Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy J Exp Med 193 2001 727 740
    • (2001) J Exp Med , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 52
    • 0031971930 scopus 로고    scopus 로고
    • Local release of interleukin-10 by transfected mouse adeno-carcinoma cells exhibits pro- and anti-inflammatory activity and results in a delayed tumor rejection
    • E. Di Carlo, A. Coletti, A. Modesti, M. Giovarelli, G. Forni, and P. Musiani Local release of interleukin-10 by transfected mouse adeno-carcinoma cells exhibits pro- and anti-inflammatory activity and results in a delayed tumor rejection Eur Cytokine Netw 9 1998 61 68
    • (1998) Eur Cytokine Netw , vol.9 , pp. 61-68
    • Di Carlo, E.1    Coletti, A.2    Modesti, A.3    Giovarelli, M.4    Forni, G.5    Musiani, P.6
  • 53
    • 0030443062 scopus 로고    scopus 로고
    • Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells by inhibition of angiogenesis
    • S. Huang, K. Xie, C.D. Bucana, S.E. Ullrich, and M. Bar-Eli Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells by inhibition of angiogenesis Clin Cancer Res 2 1996 1969 1979
    • (1996) Clin Cancer Res , vol.2 , pp. 1969-1979
    • Huang, S.1    Xie, K.2    Bucana, C.D.3    Ullrich, S.E.4    Bar-Eli, M.5
  • 54
    • 0028243641 scopus 로고
    • Observations with tumour necrosis factor gene-transfected tumours
    • Th. Blankenstein Observations with tumour necrosis factor gene-transfected tumours Folia Biol 40 1994 19 28
    • (1994) Folia Biol , vol.40 , pp. 19-28
    • Blankenstein, Th.1
  • 57
    • 0348010272 scopus 로고    scopus 로고
    • Chemical carcinogens as foreign bodies and some pitfalls • regarding cancer immune surveillance
    • •], the authors discuss the fact that current tumor models do not support the conclusion that immune surveillance, the spontaneous recognition and elimination of primary tumors by T cells, exists against tumors without viral association.
    • (2003) Adv Cancer Res , vol.90 , pp. 179-207
    • Blankenstein, Th.1    Qin, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.