Multiple signal transduction pathways mediate interleukin-4-induced 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in normal and tumoral target tissues

Journal of Steroid Biochemistry and Molecular Biology

Volumn 76, Issue 1-5, 2001, Pages 213-225

  Gingras, Sébastien ^a   Côté, Stéphanie ^a   Simard, Jacques ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

3 Hydroxysteroid dehydrogenase 5 4 Isomerase; Breast cancer; IGF 1; Insulin; Interleukin 4; IRS 1; IRS 2; MAP kinase; Phosphatidylinositol 3 kinase; Sex steroids; Stat6

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CYCLOHEXIMIDE; DACTINOMYCIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; ISOMERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; SOMATOMEDIN BINDING PROTEIN 1; STAT6 PROTEIN; WORTMANNIN;

BREAST CARCINOMA; CANCER CELL CULTURE; CANCER TISSUE; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HUMAN; MITOGENESIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TARGET ORGAN;

BASE SEQUENCE; BREAST; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; MALE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROGESTERONE REDUCTASE; PROMOTER REGIONS (GENETICS); PROSTATE; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; STEROID ISOMERASES; TUMOR CELLS, CULTURED;

EID: 0034989910     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(00)00148-5     Document Type: Conference Paper

References (58)

1. 4 isomerase gene family
2. Synergistic activation of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester
3. Stat5-mediated regulation of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene: Activation by prolactin
4. Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
5. Overlapping cis-acting elements located in the first intron of the gene for type I 3β-hydroxysteroid dehydrogenase modulate its transcriptional activity
6. The potential relevance of cytokines to ovarian physiology: The emerging role of resident ovarian cells of the white blood cell series
7. Cytokine modulation of progesterone and estradiol secretion in cultures of luteinized human granulosa cells
8. Leukocytes modulate 11β hydroxysteroid dehydrogenase (11β-HSD) activity in human granulosa-lutein cell cultures
9. Effects of interleukin (IL)-6 on luteinizing hormone- and IL-1β-induced ovulation and steroidogenesis in the rat ovary
10. The interaction of cytokines in regulating oestradiol 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells
11. Interactive effects of interleukin-6, 17β-estradiol and progesterone on growth and 17β-hydroxysteroid dehydrogenase activity in human breast carcinoma cells
12. Insulin-like growth factor type I and insulin-like growth factor type II stimulate oestradiol-17β hydroxysteroid dehydrogenase (reductive) activity in breast cancer cells
13. Interleukin-1 and interleukin-6 in breast cyst fluid: Their role in regulating aromatase activity in breast cancer cells
14. The role of local estrogen biosynthesis in males and females
15. Interleukin-4: A prototypic immunoregulatory lymphokine
16. Inhibition of colon and breast carcinoma cell growth by interleukin-4
17. Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells
18. Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells
19. 4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13
20. Induction of 3β-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon, and cervix cancer cell lines
21. Multiple pathways mediate interleukin-4 induced 3β-hydroxysteroid dehydrogenase/isomerase type 1 gene expression in human breast cancer cells
22. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
23. An interleukin-4-induced transcription factor: IL-4 Stat
24. STATs: Signal transducers and activators of transcription
25. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
26. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
27. STAT6: Its role in interleukin-4-mediated biological functions
28. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth
29. IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells
30. Insulin signal transduction and the IRS proteins
31. Common elements in interleukin-4 and insulin signaling pathways in factor-dependent hematopoietic cells
32. Role of IRS-2 in insulin and cytokine signalling
33. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
34. Immunohistochemical study of TGF-α, TGF-β1, EGFR, and IGF-1 expression in human breast carcinoma
35. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
36. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
37. Role of IRS-1-GRB-2 complexes in insulin signaling
38. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
39. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
40. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3
41. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
42. Platelet-derived growth factor activates protein kinase C ε through redundant and independent signaling pathways involving phospholipase C γ or phosphatidylinositol 3-kinase
43. Effects of phorbol esters on insulin-induced activation of phosphatidylinositol 3-kinase, glucose transport, and glycogen synthase in rat adipocytes
44. The function of GRB2 in linking the insulin receptor to Ras signaling pathways
45. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and shc: Implications for insulin control of ras signalling
46. Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin
47. Involvement of ras p2l protein in signal-transduction pathways from interleukin-2, interleukin-3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin-4
48. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway
49. Interleukin-4 induces activation of mitogen-activated protein kinase and phosphorylation of shc in human keratinocytes
50. Evidence for a role of phosphatidylinositol 3-kinase in IL-4-induced germline C epsilon transcription
51. Protein kinase C and its substrates
52. In vitro IgE production by interleukin-4-stimulated human peripheral blood mononuclear cells is suppressed by rapamycin
53. Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin
54. Interleukin-4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin
55. Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins
56. IL-4 stimulation of ovarian 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase type 2 gene expression: Mechanisms of activation
57. p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
58. β-Casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary gland-specific nuclear factor