Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease

Journal of Biological Chemistry

Volumn 285, Issue 39, 2010, Pages 29671-29675

  Apostol, Marcin I ^a   Sawaya, Michael R ^a   Cascio, Duilio ^a   Eisenberg, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FASTENERS;

CRYSTALLOGRAPHIC STUDIES; INTERMOLECULAR INTERACTIONS; MOLECULAR BASIS; PRION DISEASE; PRION PROTEIN; SINGLE-NUCLEOTIDE POLYMORPHISMS; STRUCTURAL CHANGE; STRUCTURE-BASED;

POLYMORPHISM;

METHIONINE; PRION PROTEIN; VALINE; PRION;

AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; CODON; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DISEASE PREDISPOSITION; GENE LOCUS; HOMOZYGOSITY; HUMAN; PATHOGENESIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RESIDUE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMISTRY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MISSENSE MUTATION; PRION; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRION DISEASES; PRIONS; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956941468     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.158303     Document Type: Article

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