Balancing selection at the prion protein gene consistent with prehistoric Kurulike epidemics

Science

Volumn 300, Issue 5619, 2003, Pages 640-643

  Mead, Simon ^a   Stumpf, Michael P H ^b   Whitfield, Jerome ^a,c   Beck, Jonathan A ^a   Poulter, Mark ^a   Campbell, Tracy ^a   Uphill, James B ^a   Goldstein, David ^b   Alpers, Michael ^a,c,d   Fisher, Elizabeth M C ^a   Collinge, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^d CURTIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; MORPHOLOGY; PROTEINS;

MORTUARY FEASTS;

GENES;

PRION PROTEIN;

GENE; PREHISTORIC; PRION DISEASE;

ARTICLE; CANNIBALISM; DISEASE RESISTANCE; DNA POLYMORPHISM; EPIDEMIC; EVOLUTION; GENE FREQUENCY; GENE LOCATION; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; KURU; PAPUA NEW GUINEA; PRIORITY JOURNAL; SURVIVAL;

ADULT; ANIMALS; CANNIBALISM; CHILD; CODON; CREUTZFELDT-JAKOB SYNDROME; DISEASE OUTBREAKS; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; HAPLOTYPES; HETEROZYGOTE; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, ANCIENT; HOMOZYGOTE; HUMANS; IMMUNITY, NATURAL; KURU; LINKAGE DISEQUILIBRIUM; MALE; METHIONINE; MIDDLE AGED; MUTATION; PAPUA NEW GUINEA; POLYMORPHISM, GENETIC; PRPC PROTEINS; SELECTION (GENETICS); VALINE;

EID: 0242684410     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083320     Document Type: Article

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