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Volumn 7, Issue SUPPL. 3, 2010, Pages

Computational model of cell positioning: Directed and collective migration in the intestinal crypt epithelium

Author keywords

Cell translocation; Cellular potts model; Differential adhesion; EphB ephrinB; Epithelial cell positioning

Indexed keywords

CELL ADHESION; CELL DEATH; CELL PROLIFERATION; GROWTH KINETICS; HISTOLOGY; TISSUE;

EID: 77956896626     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2010.0018.focus     Document Type: Article
Times cited : (45)

References (52)
  • 2
    • 18644376279 scopus 로고    scopus 로고
    • β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of ephb/ephrinb
    • doi:10. 1016/S0092-8674(02)01015-2
    • Batlle, E. et al. 2002 β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of ephb/ephrinb. Cell 111, 251-263. (doi:10. 1016/S0092-8674(02)01015-2)
    • (2002) Cell , vol.111 , pp. 251-263
    • Batlle, E.1
  • 3
    • 0032948289 scopus 로고    scopus 로고
    • Regulation of cadherin function by rho and rac: Modulation by junction maturation and cellular context
    • Braga, V. M., Del Maschio, A., Machesky, L. & Dejana, E. 1999 Regulation of cadherin function by rho and rac: modulation by junction maturation and cellular context. Mol. Biol. Cell. 10, 9-22.
    • (1999) Mol. Biol. Cell. , vol.10 , pp. 9-22
    • Braga, V.M.1    Del Maschio, A.2    Machesky, L.3    Dejana, E.4
  • 4
    • 31544433363 scopus 로고    scopus 로고
    • EphB/ephrinB receptors and wnt signaling in colorectal cancer
    • doi:10.1158/0008-5472.CAN-05-3849
    • Clevers, H. & Batlle, E. 2006 EphB/ephrinB receptors and wnt signaling in colorectal cancer. Cancer Res. 66, 2-5. (doi:10.1158/0008-5472.CAN- 05-3849)
    • (2006) Cancer Res , vol.66 , pp. 2-5
    • Clevers, H.1    Batlle, E.2
  • 5
    • 3042587215 scopus 로고    scopus 로고
    • Bidirectional signaling mediated by ephrin-b2 and ephb2 controls urorectal development
    • doi:10.1016/j.ydbio.2004.03.027
    • Dravis, C., Yokoyama, N., Chumley, M., Cowan, C., Silvany, R., Shay, J., Baker, L. & Henkemeyer, M. 2004 Bidirectional signaling mediated by ephrin-b2 and ephb2 controls urorectal development. Dev. Biol. 271, 272-290. (doi:10.1016/j.ydbio.2004.03.027)
    • (2004) Dev. Biol. , vol.271 , pp. 272-290
    • Dravis, C.1    Yokoyama, N.2    Chumley, M.3    Cowan, C.4    Silvany, R.5    Shay, J.6    Baker, L.7    Henkemeyer, M.8
  • 6
    • 0000825469 scopus 로고
    • Simulations of the differential adhesion driven rearrangement of biological cells
    • doi:10.1103/PhysRevE.47.2128
    • Glazier, J. A. & Graner, F. 1993 Simulations of the differential adhesion driven rearrangement of biological cells. Phys. Rev. E 47, 2128-2154. (doi:10.1103/PhysRevE.47.2128)
    • (1993) Phys. Rev. E , vol.47 , pp. 2128-2154
    • Glazier, J.A.1    Graner, F.2
  • 7
    • 24144438180 scopus 로고    scopus 로고
    • Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro
    • Hafner, C. et al. 2005 Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro. World J. Gastroenterol. 11, 4024-4031.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 4024-4031
    • Hafner, C.1
  • 8
    • 21244432037 scopus 로고    scopus 로고
    • Collective movement of epithelial cells on a collagen gel substrate
    • DOI 10.1529/biophysj.104.047654
    • Haga, H., Irahara, C., Kobayashi, R., Nakagaki, T. & Kawabata, K. 2005 Collective movement of epithelial cells on a collagen gel substrate. Biophys. J. 88, 2250-2256. (doi:10.1529/biophysj.104.047654) (Pubitemid 40976231)
    • (2005) Biophysical Journal , vol.88 , Issue.3 , pp. 2250-2256
    • Haga, H.1    Irahara, C.2    Kobayashi, R.3    Nakagaki, T.4    Kawabata, K.5
  • 9
    • 0029940608 scopus 로고    scopus 로고
    • Epithelial cell migration in the intestine
    • doi:10.1006/cbir.1996.0018
    • Heath, J. P. 1996 Epithelial cell migration in the intestine. Cell Biol. Int. 20, 139-146. (doi:10.1006/cbir.1996.0018)
    • (1996) Cell Biol. Int. , vol.20 , pp. 139-146
    • Heath, J.P.1
  • 10
    • 33744980881 scopus 로고    scopus 로고
    • Ephb receptors coordinate migration and proliferation in the intestinal stem cell niche
    • doi:10.1016/j.cell.2006.04.030
    • Holmberg, J., Genander, M., Halford, M., Annern, C., Sondell, M., Chumley, M., Silvany, R., Henkemeyer, M. & Frisn, J. 2006 Ephb receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell 125, 1151-1163. (doi:10.1016/j.cell.2006.04.030)
    • (2006) Cell , vol.125 , pp. 1151-1163
    • Holmberg, J.1    Genander, M.2    Halford, M.3    Annern, C.4    Sondell, M.5    Chumley, M.6    Silvany, R.7    Henkemeyer, M.8    Frisn, J.9
  • 12
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation and signaling in cell adhesion
    • doi:10.1016/0092-8674(92)90115-S
    • Hynes, R. O. 1992 Integrins: versatility, modulation and signaling in cell adhesion. Cell 69, 11-25. (doi:10.1016/0092-8674(92)90115-S)
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 13
    • 34247267072 scopus 로고    scopus 로고
    • Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
    • doi:10.1073/pnas.0611179104
    • Johnston, M. D., Edwards, C. M., Bodmer, W. F., Maini, P. K. & Chapman, S. J. 2007 Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc. Natl Acad. Sci. USA 104, 4008-4013. (doi:10.1073/pnas.0611179104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 4008-4013
    • Johnston, M.D.1    Edwards, C.M.2    Bodmer, W.F.3    Maini, P.K.4    Chapman, S.J.5
  • 14
    • 33745609784 scopus 로고    scopus 로고
    • Moving forward moving backward: Directional sorting of chemotactic cells due to size and adhesion differences
    • doi:10.1371/journal.pcbi.0020056
    • Käfer, J., Hogeweg, P. & Marée, A. F. M. 2006 Moving forward moving backward: directional sorting of chemotactic cells due to size and adhesion differences. PLoS Comput. Biol. 2, 0518-0529. (doi:10.1371/journal. pcbi.0020056)
    • (2006) PLoS Comput. Biol. , vol.2 , pp. 518-529
    • Käfer, J.1    Hogeweg, P.2    Marée, A.F.M.3
  • 15
    • 33846166087 scopus 로고    scopus 로고
    • Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia
    • doi:10.1242/dev.02662
    • Kasemeier-Kulesa, J., Bradley, R., Pasquale, E., Lefcort, F. & Kulesa, P. 2006 Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia. Development 133, 4839-4847. (doi:10.1242/dev.02662)
    • (2006) Development , vol.133 , pp. 4839-4847
    • Kasemeier-Kulesa, J.1    Bradley, R.2    Pasquale, E.3    Lefcort, F.4    Kulesa, P.5
  • 16
    • 84990576541 scopus 로고
    • Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity
    • Kaur, P. & Potten, C. S. 1986a Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity. Cell Tissue Kinetics 19, 601-610.
    • (1986) Cell Tissue Kinetics , vol.19 , pp. 601-610
    • Kaur, P.1    Potten, C.S.2
  • 17
    • 84990553682 scopus 로고
    • Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine
    • Kaur, P. & Potten, C. S. 1986b Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine. Cell Tissue Kinetics 19, 611-625.
    • (1986) Cell Tissue Kinetics , vol.19 , pp. 611-625
    • Kaur, P.1    Potten, C.S.2
  • 18
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of eph and ephrin signaling
    • doi:10.1038/nrm856
    • Kullander, K. & Klein, R. 2002 Mechanisms and functions of eph and ephrin signaling. Nat. Rev. Mol. Cell Biol. 3, 475-486. (doi:10.1038/nrm856)
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 19
    • 0032493903 scopus 로고    scopus 로고
    • Role of iqgap1, a target of the small gtpases cdc42 and rac1, in regulation of e-cadherin mediated cell-cell adhesion
    • doi:10.1126/science.281.5378.832
    • Kuroda, S. et al. 1998 Role of iqgap1, a target of the small gtpases cdc42 and rac1, in regulation of e-cadherin mediated cell-cell adhesion. Science 28, 832-835. (doi:10.1126/science.281.5378.832)
    • (1998) Science , vol.28 , pp. 832-835
    • Kuroda, S.1
  • 20
    • 84990553606 scopus 로고
    • Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt
    • Loeffler, M., Stein, R., Wichmann, H. E., Potten, C. S., Kaur, P. & Chwalinski, S. 1986 Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt. Cell Tissue Kinetics 19, 627-645.
    • (1986) Cell Tissue Kinetics , vol.19 , pp. 627-645
    • Loeffler, M.1    Stein, R.2    Wichmann, H.E.3    Potten, C.S.4    Kaur, P.5    Chwalinski, S.6
  • 21
    • 0141839882 scopus 로고    scopus 로고
    • Rac-dependent trans-endocytosis of ephrinbs regulates eph-ephrin contact repulsion
    • doi:10.1038/ncb1044
    • Marston, D. J., Dickinson, S. & Nobes, C. D. 2003 Rac-dependent trans-endocytosis of ephrinbs regulates eph-ephrin contact repulsion. Nat. Cell Biol. 5, 879-888. (doi:10.1038/ncb1044)
    • (2003) Nat. Cell Biol. , vol.5 , pp. 879-888
    • Marston, D.J.1    Dickinson, S.2    Nobes, C.D.3
  • 22
    • 0034902642 scopus 로고    scopus 로고
    • Cell migration and organization in the intestinal crypt using a lattice-free model
    • doi:10.1046/j.0960-7722.2001.00216.x
    • Meineke, F. A., Potten, C. S. & Loeffler, M. 2001 Cell migration and organization in the intestinal crypt using a lattice-free model. Cell Prolif. 34, 253-266. (doi:10.1046/j.0960-7722.2001.00216.x)
    • (2001) Cell Prolif , vol.34 , pp. 253-266
    • Meineke, F.A.1    Potten, C.S.2    Loeffler, M.3
  • 23
    • 29144462629 scopus 로고    scopus 로고
    • Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling
    • doi:10.1016/j.ydbio.2005. 10.003
    • Merks, R. M. H., Brodsky, S. V., Goligorksy, M. S., Newman, S. A. & Glazier, J. A. 2006 Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling. Dev. Biol. 289, 44-54. (doi:10.1016/j.ydbio.2005. 10.003)
    • (2006) Dev. Biol. , vol.289 , pp. 44-54
    • Merks, R.M.H.1    Brodsky, S.V.2    Goligorksy, M.S.3    Newman, S.A.4    Glazier, J.A.5
  • 24
    • 0033785409 scopus 로고    scopus 로고
    • Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
    • doi:10.1038/35000008
    • Miao, H., Burnett, E., Kinch, M., Simmon, E. & Wang, B. 2000 Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2, 62-69. (doi:10.1038/35000008)
    • (2000) Nat. Cell Biol. , vol.2 , pp. 62-69
    • Miao, H.1    Burnett, E.2    Kinch, M.3    Simmon, E.4    Wang, B.5
  • 25
    • 12544252826 scopus 로고    scopus 로고
    • Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases
    • Miao, H., Strebhardt, K., Pasquale, E., Shen, T., Guan, J. & Wang, B. 2005 Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J. Biol. Chem. 2, 923-932.
    • (2005) J. Biol. Chem. , vol.2 , pp. 923-932
    • Miao, H.1    Strebhardt, K.2    Pasquale, E.3    Shen, T.4    Guan, J.5    Wang, B.6
  • 27
    • 0000273795 scopus 로고
    • The dissociation and aggregation of cells from organ rudiments of early chick embryo
    • Moscona, A. & Moscona, H. 1952 The dissociation and aggregation of cells from organ rudiments of early chick embryo. J. Anat. 86, 287-301.
    • (1952) J. Anat. , vol.86 , pp. 287-301
    • Moscona, A.1    Moscona, H.2
  • 28
    • 25144492370 scopus 로고    scopus 로고
    • EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion
    • Nakada, M., Niska, J., Tran, N., McDonough, W. & Berens, M. 2005 EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am. J. Pathol. 167, 565-576.
    • (2005) Am. J. Pathol. , vol.167 , pp. 565-576
    • Nakada, M.1    Niska, J.2    Tran, N.3    McDonough, W.4    Berens, M.5
  • 29
    • 0034026122 scopus 로고    scopus 로고
    • Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion
    • O'Connell, C. B. & Wang, Y.-L. 2000 Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol. Biol. Cell. 11, 1765-1774.
    • (2000) Mol. Biol. Cell. , vol.11 , pp. 1765-1774
    • O'Connell, C.B.1    Wang, Y.-L.2
  • 30
    • 5044240692 scopus 로고    scopus 로고
    • Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly
    • doi:10.1016/j.devcel.2004.09.006
    • Poliakov, A., Cotrina, M. & Wilkinson, D. G. 2004 Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell 7, 465-480. (doi:10.1016/j.devcel.2004.09.006)
    • (2004) Dev. Cell , vol.7 , pp. 465-480
    • Poliakov, A.1    Cotrina, M.2    Wilkinson, D.G.3
  • 31
    • 0030987665 scopus 로고    scopus 로고
    • The intestinal epithelial stem cell: The mucosal governor
    • doi:10.1046/j.1365-2613.1997.280362.x
    • Potten, C. S., Booth, C. & Pritchard, D. M. 1997 The intestinal epithelial stem cell: the mucosal governor. Int. J. Exp. Pathol. 78, 219-243. (doi:10.1046/j.1365-2613.1997.280362.x)
    • (1997) Int. J. Exp. Pathol. , vol.78 , pp. 219-243
    • Potten, C.S.1    Booth, C.2    Pritchard, D.M.3
  • 32
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: Two sides of a coin
    • doi:10.1126/science.1104815
    • Radtke, F. & Clevers, H. 2005 Self-renewal and cancer of the gut: two sides of a coin. Science 307, 1904-1909. (doi:10.1126/science.1104815)
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 33
    • 4644307189 scopus 로고    scopus 로고
    • Expression of EphA2 and E-cadherin in colorectal cancer: Correlation with cancer metastasis
    • Saito, T., Masuda, N., Miyazaki, T., Kanoh, K., Suzuki, H., Shimura, T., Asao, T. & Kuwano, H. 2004 Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis. Oncol. Rep. 11, 605-611.
    • (2004) Oncol. Rep. , vol.11 , pp. 605-611
    • Saito, T.1    Masuda, N.2    Miyazaki, T.3    Kanoh, K.4    Suzuki, H.5    Shimura, T.6    Asao, T.7    Kuwano, H.8
  • 34
    • 0344413420 scopus 로고    scopus 로고
    • Live and let die in the intestinal epithelium
    • doi:10.1016/j.ceb.2003.10.012
    • Sancho, E., Batlle, E. & Clevers, H. 2003 Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol. 15, 18. (doi:10.1016/j.ceb.2003. 10.012)
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 18
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 35
    • 0038699078 scopus 로고    scopus 로고
    • Control of epidermal cell clusters by notch-mediated lateral inhibition
    • doi:10.1016/S0012-1606(03)00107-6
    • Savill, N. J. & Sherratt, J. A. 2003 Control of epidermal cell clusters by notch-mediated lateral inhibition. Dev. Biol. 258, 141-153. (doi:10.1016/S0012-1606(03)00107-6)
    • (2003) Dev. Biol. , vol.258 , pp. 141-153
    • Savill, N.J.1    Sherratt, J.A.2
  • 36
    • 2542446343 scopus 로고    scopus 로고
    • Development and differentiation of gut endocrine cells
    • doi:10.1210/en.2004-0051
    • Schonhoff, S. E., Giel-Moloney, M. & Leiter, A. B. 2004 Development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644. (doi:10.1210/en.2004-0051)
    • (2004) Endocrinology , vol.145 , pp. 2639-2644
    • Schonhoff, S.E.1    Giel-Moloney, M.2    Leiter, A.B.3
  • 37
    • 0000829358 scopus 로고
    • On the mechanism of tissue reconstruction by dissociated cells. I Population kinetics, differential adhesiveness, and the absence of directed migration
    • doi:10.1073/pnas.48.9.1577
    • Steinberg, M. 1962 On the mechanism of tissue reconstruction by dissociated cells. I Population kinetics, differential adhesiveness, and the absence of directed migration. Proc. Natl Acad. Sci. USA 48, 1577-1582. (doi:10.1073/pnas.48.9.1577)
    • (1962) Proc. Natl Acad. Sci. USA , vol.48 , pp. 1577-1582
    • Steinberg, M.1
  • 38
    • 4644340270 scopus 로고    scopus 로고
    • Townes and Holtfreter (1955): Directed movements and selective adhesion of embryonic amphibian cells
    • doi:10.1002/jez.a.114
    • Steinberg, M. S. & Gilbert, S. F. 2004 Townes and Holtfreter (1955): directed movements and selective adhesion of embryonic amphibian cells. J. Exp. Zool. A Comp. Exp. Biol. 301A, 701-706. (doi:10.1002/jez.a.114)
    • (2004) J. Exp. Zool. A Comp. Exp. Biol. , vol.301 A , pp. 701-706
    • Steinberg, M.S.1    Gilbert, S.F.2
  • 39
    • 0028013294 scopus 로고
    • Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression
    • doi:10.1073/pnas.91.1.206
    • Steinberg, M. & Takeichi, M. 1994 Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc. Natl Acad. Sci. USA 91, 206-209. (doi:10.1073/pnas.91.1.206)
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 206-209
    • Steinberg, M.1    Takeichi, M.2
  • 40
    • 84961184728 scopus 로고
    • Directed movements and selective adhesion of embryonic amphibian cells
    • doi:10.1002/jez.1401280105
    • Townes, P. & Holtfreter, J. 1955 Directed movements and selective adhesion of embryonic amphibian cells. J. Exp. Zool. 128, 53-118. (doi:10.1002/jez.1401280105)
    • (1955) J. Exp. Zool. , vol.128 , pp. 53-118
    • Townes, P.1    Holtfreter, J.2
  • 41
    • 0025332745 scopus 로고
    • Epithelial basement membrane of mouse jejunum. Evidence for laminin turnover along the entire crypt-villus axis
    • doi:10.1172/JCI114720
    • Trier, J. S., Allan, C. H., Abrahamson, D. R. & Hagen, S. J. 1990 Epithelial basement membrane of mouse jejunum. Evidence for laminin turnover along the entire crypt-villus axis. J. Clin. Invest. 86, 87-95. (doi:10.1172/JCI114720)
    • (1990) J. Clin. Invest. , vol.86 , pp. 87-95
    • Trier, J.S.1    Allan, C.H.2    Abrahamson, D.R.3    Hagen, S.J.4
  • 42
    • 0020823655 scopus 로고
    • Theoretical implications for cell migration through the crypt and the villus of labeling studies conducted at each position within the crypt
    • Tsubouchi, S. 1983 Theoretical implications for cell migration through the crypt and the villus of labeling studies conducted at each position within the crypt. Cell Tissue Kinetics 16, 441-456.
    • (1983) Cell Tissue Kinetics , vol.16 , pp. 441-456
    • Tsubouchi, S.1
  • 43
    • 0036304182 scopus 로고    scopus 로고
    • Intercellular adhesion and cancer invasion: A discrete simulation using the extended Potts model
    • doi:10.1006/jtbi.2001.2522
    • Turner, S. & Sherratt, J. A. 2002 Intercellular adhesion and cancer invasion: a discrete simulation using the extended Potts model. J. Theor. Biol. 216, 85-100. (doi:10.1006/jtbi.2001.2522)
    • (2002) J. Theor. Biol. , vol.216 , pp. 85-100
    • Turner, S.1    Sherratt, J.A.2
  • 44
    • 19644377230 scopus 로고    scopus 로고
    • Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells
    • Wang, B., Wylie, F. G., Teasdale, R. D. & Stow, J. L. 2005 Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells. Am. J. Physiol. Cell Physiol. 288, C1411-C1419.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.288
    • Wang, B.1    Wylie, F.G.2    Teasdale, R.D.3    Stow, J.L.4
  • 45
    • 0035287473 scopus 로고    scopus 로고
    • Multiple roles of eph receptors and ephrins in neural development
    • doi:10.1038/35058515
    • Wilkinson, D. G. 2001 Multiple roles of eph receptors and ephrins in neural development. Nat. Rev. Neurosci. 2, 155-164. (doi:10.1038/35058515)
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 155-164
    • Wilkinson, D.G.1
  • 46
    • 0141617343 scopus 로고    scopus 로고
    • How attraction turns to repulsion
    • doi:10.1038/ncb1003-851
    • Wilkinson, D. 2003 How attraction turns to repulsion. Nat. Cell Biol. 5, 851-853. (doi:10.1038/ncb1003-851)
    • (2003) Nat. Cell Biol. , vol.5 , pp. 851-853
    • Wilkinson, D.1
  • 47
    • 0030296507 scopus 로고    scopus 로고
    • Disruption of cell adhesion in Xenopus embryos by pagliaccio, and eph-class receptor tyrosine kinase
    • doi:10.1006/dbio.1996.0262
    • Winning, R. S., Scales, J. B. & Sargent, T. D. 1996 Disruption of cell adhesion in Xenopus embryos by pagliaccio, and eph-class receptor tyrosine kinase. Dev. Biol. 179, 309-319. (doi:10.1006/dbio.1996.0262)
    • (1996) Dev. Biol. , vol.179 , pp. 309-319
    • Winning, R.S.1    Scales, J.B.2    Sargent, T.D.3
  • 48
    • 0023894101 scopus 로고
    • A clonal marker induced by mutation in mouse intestinal epithelium
    • doi:10.1038/333463a0
    • Winton, D. J., Blount, M. A. & Ponder, B. A. J. 1988 A clonal marker induced by mutation in mouse intestinal epithelium. Nature 333, 463-466. (doi:10.1038/333463a0)
    • (1988) Nature , vol.333 , pp. 463-466
    • Winton, D.J.1    Blount, M.A.2    Ponder, B.A.J.3
  • 50
    • 0034729895 scopus 로고    scopus 로고
    • Roles of eph receptors and ephrins in segmental patterning
    • doi:10.1098/rstb.2000.0635
    • Xu, Q., Mellitzer, G. & Wilkinson, D. G. 2000 Roles of eph receptors and ephrins in segmental patterning. Phil. Trans. R. Soc. Lond. B 355, 993-1002. (doi:10.1098/rstb.2000.0635)
    • (2000) Phil. Trans. R. Soc. Lond. , vol.355 , pp. 993-1002
    • Xu, Q.1    Mellitzer, G.2    Wilkinson, D.G.3
  • 51
    • 0141839883 scopus 로고    scopus 로고
    • Ephb-ephrinb bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
    • doi:10.1038/ncb1045
    • Zimmer, M., Palmer, A., Kohler, J. & Klein, R. 2003 Ephb-ephrinb bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat. Cell Biol. 5, 869-878. (doi:10.1038/ncb1045)
    • (2003) Nat. Cell Biol. , vol.5 , pp. 869-878
    • Zimmer, M.1    Palmer, A.2    Kohler, J.3    Klein, R.4
  • 52
    • 0033598742 scopus 로고    scopus 로고
    • An Eph receptor regulates integrin activity through R-Ras
    • doi:10.1073/pnas.96.24.13813
    • Zou, J., Wang, B., Kalo, M., Zisch, A., Pasquale, E. & Ruoslahti, E. 1999 An Eph receptor regulates integrin activity through R-Ras. Proc. Natl Acad. Sci. USA 96, 13 813-13 818. (doi:10.1073/pnas.96.24.13813)
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 13813-13818
    • Zou, J.1    Wang, B.2    Kalo, M.3    Zisch, A.4    Pasquale, E.5    Ruoslahti, E.6


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