Protective effect of Phyllanthus niruri on alcohol and heated sunflower oil induced hyperlipidemia in Wistar rats

Toxicology Mechanisms and Methods

Volumn 20, Issue 8, 2010, Pages 498-503

  Latha, P ^a   Chaitanya, D ^a   Rukkumani, R ^a  

^a PONDICHERRY UNIVERSITY   (India)

Author keywords

Alcohol; Hyperlipidemia; Lipids; Phyllanthus niruri; PUFA

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FATTY ACID; LIVER ENZYME; PHOSPHOLIPID; PHYLLANTHUS NIRURI EXTRACT; SUNFLOWER OIL; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CHEMICAL PARAMETERS; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; FATTY ACID BLOOD LEVEL; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIVER INJURY; MALE; MEDICINAL PLANT; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PHYLLANTHUS; PHYLLANTHUS NIRURI; PLANT LEAF; PRIORITY JOURNAL; RAT; SUNFLOWER; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; DIETARY FATS, UNSATURATED; DRUG INTERACTIONS; ETHANOL; FATTY LIVER; HOT TEMPERATURE; HYPERLIPIDEMIAS; LIPIDS; LIVER; MALE; PHYLLANTHUS; PLANT EXTRACTS; PLANT LEAVES; PLANT OILS; RATS; RATS, WISTAR;

HELIANTHUS; PHYLLANTHUS NIRURI; RATTUS; RATTUS NORVEGICUS;

EID: 77956858263     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.511301     Document Type: Article

References (41)

1. Aruna K, Kalpana C, Menon VP. 2002. Toxic effects of sunflower oil on ethanol treated rats. Hepatol Res 24:125-135.
2. Aruna K, Rukkumani R, Varma PS, Menon VP. 2007. Role of an aminothiazole derivative on ethanol-induced toxicity. Toxicol Mech Meth 17:33-40.
3. Ashakumari L, Vijayammal PL. 1993. Additive effect of alcohol and nicotine on lipid metabolism in rats. Ind J Exp Biol 31:270-274.
4. Asoh S, Ohta S. 2007. PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. Adv Drug Deli Rev 60:499-516.
5. Bradbury MW. 2006. Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 290:194-198.
6. Bhattacharjee R, Parames C. 2007. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol 45:817-826.
7. Chang CC, Lien YC, Karin CS, Liu C, Lee SS. 2003. Lignans from phyllanthus urinaria. Phytochem 63:825-833.
8. Devipriya N, Ram Sudheer A, Srinivasan M, Menon VP. 2007. Effect of ellagic acid, plant polyphenol, on fibrotic markers (MMPs and TIMPs) during alcohol-induced hepatotoxicity. Toxicol Mech Meth 17:349-356.
9. Falholt K, Falholt W, Lund B. 1973. An easy colorimetric method for routine determination of free fatty acids in plasma. J Clin Chim Acta 46:105.
10. Farell SO, Jackson MJ. 1997. Dietary PUFA, vitamin E and hypoxia/reoxygenateed -induced damage to cardiac tissue. Clin Chim Acta 267: 197-211.
11. Fielding BA, Reids G, Grandy M, Humphreys SM, Evans K, Frayn KN. 2000. Ethanol with a mixed meal increases post prandial triglycerides but decreases post prandial non esterified fatty acid concentrations. Br J Nutr 83:597-604.
12. Folch J, Lees M, Solane SGH. 1957. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 26:497-509.
13. Foster CS, Dunn O. 1973. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. J Clin Chim Acta 19:338-340.
14. Galli A, Price D, Crabb D. 1999. High level expression of rat class 1 alcohol dehydrogenase is sufficient for ethanol induced fat for accumulation is transduced HeLa cells. J Hepatol 29:1164-1170.
15. Harish R, Shivanandappa T. 2006. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem 95:180-185.
16. Harper CR, Jacobson TA. 2001. The fate of life. The role of omega-3-fatty acids in the prevention of coronary heart disease. J Arch Intern Med 161:2185-2191.
17. Ido Y, Kilo C, Williamson JR. 1997. Cytosolic NADH/NAD +, free radicals, and vascular dysfunction in early diabetes mellitus. Diabetologia 40:S115-S117.
18. Kapur V, Pillai KK, Hussain SZ, Balani DK. 1994. Hepatoprotective activity of jigrine on liver damage caused by alcohol, carbon tetrachloride and paracetamol in rats. Ind J Pharmacol 26:35-40.
19. Kohl M, Wedel T, Entenmann A, Stuttmann J, Bendiks M, Loff S, Koster S, Ortfeld S, Bos I. 2007. Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model. J Pediatr Gastro Nutr 44:237-244.
20. Lieber CS. 2000. Alcoholic liver disease. New insights in pathogenesis lead to new treatment. J Hepatol 32:113-128.
21. Lu Y, Cederbaum AI. 2008. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44:723-773.
22. Merchant NK, Penumetcha M, Meilhac O, Parthasarathy S. 2002. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. The American Society for Nutritional Sciences. J Nutr 132:3256-3262.
23. Parker JG, Aweerbach W, Goldberg DM. 1996. Effect of alcohol on lipoprotein metabolism. Enzyme 43:47-55.
24. Polonio CG, Garcia-Linares MC, Garcia-Arias MT, Varela SL, Garcia-Fernandez MC, Terpstra AHM, Sanchez-Muniz FJ. 2004. Thermally oxidised sunflower- seed oil increases liver and serum peroxidation and modifies lipoprotein composition in rats. Brit J Nutr 92:257-265.
25. Rajesh Kumar NV, Joy KL, Girija K, Ramsewak RS, Nair MG, Ramadasan K. 2002. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. J Ethno Pharmacol 81:17-22.
26. Raza M, Ahmad M, Gado A, Al-shabanah O. 2003. A comparison of hepatoprotective activities of amino guanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Compa Biochem Physiol 134:451-456.
27. Reitman S, Frankel S. 1957. A colorimetric method for the determination of serum glutamic, oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56-63.
28. Ronis MJJ, Korourian S, Zipperman M, Hakkak R, Badger TM. 2004. Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition. Am Soc Nutr Sci J Nutr 134:904-912.
29. Rukkumani R, Aruna K, Suresh Varma P, Menon VP. 2004. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Pharm Pharmaceut Sci 7:274-283.
30. Rukkumani R, Aruna K, Varma PS, Viswanathan P, Rajasekaran KN, Menon VP. 2005. Protective role of a novel curcuminoid on alcohol and PUFA induced hyperlipidemia. Toxicol Mech Meth 15:227-234.
31. Rukkumani R, Sri Balasubashini M, Menon VP. 2002. Compartive effects of curcumin on alcohol and polyunsaturated fatty acid induced hyperlipidemia. J Pharmacol Res 46:257-264.
32. Shanmugarajan TS, Prithwish N, Somasundaram I, Arunsundar M, Niladri M, Lavande JP, Ravichandiran V. 2008. Mitigation of azathioprine-induced oxidative hepatic injury by the flavonoid quercetin in wistar rats. Toxicol Mech Meth 18:653-660.
33. Shanmugam KR, Ramakrishna CH, Mallikarjuna K, Sathyavelu Reddy K. 2009. Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress. Indian J Nephrol 19:101-106.
34. Sies H, Stahl W, Sevanian A. 2005. Nutritional, dietary and postprandial oxidative stress. The American Society for Nutritional Sciences. J Nutr 135:969-972.
35. Sudheesh S, Presannakumar G, Vijayakumar S, Vijayalakshmi NR. 1997. Hypolipidemic effect of flavonoids from Solanum melongena. Plant Food Nutr 51:321-330.
36. Sudheesh S, Vijayalakshmi NR. 1999. Flavonoids lower lipid profiles: a screening study. South Asian J Prev Cardiol 3:103-107.
37. Thurman RG, Bradford BU, Limuro Y, Frankenberg MV, Knecht KT, Connor HD. 1999. Mechanisms of alcohol induced hepatotoxicity: studies in rats. Front Biosci 4:42-46.
38. Togola A, Diallo D, Dembel S, Barsett S, Paulsen BS. 2005. Ethnopharmacological survey of different uses of seven medicinal plants from Mali, (West Africa) in the regions Doila, Kolokani and Siby. J Ethnobiol Ethnomed 1:7.
39. Vaziri ND, Liang K, Azad H. 2000. Effect of cyclosporine on HMG-CoA reductase, cholesterol 7a-hydroxylase, LDL receptor, HDL Rreceptor, VLDL receptor, and lipoprotein lipase expressions. J Pharmacol Exp Therapeut 294:778-783.
40. Zilversmit DB, Davis AK. 1950. Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 35:155.
41. Zlatkis A, Zak B, Boyle AJ. 1953. A new method for the direct determination of serum cholesterol. J Lab Clin Med 45:486.