cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 3, 2010, Pages

  Stephens, R Scott ^a   Rentsendorj, Otgonchimeg ^a   Servinsky, Laura E ^a   Moldobaeva, Aigul ^a   Damico, Rachel ^a   Pearse, David B ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Apoptosis; Catalase; Glutathione peroxidase; Hydrogen peroxide; Necrosis

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CATALASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLOHEXIMIDE; DICHLORODIHYDROFLUORESCEIN; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; 8 ((4 CHLOROPHENYL)THIO)CYCLIC 3',5' GMP; 8-((4-CHLOROPHENYL)THIO)CYCLIC-3',5'-GMP; ANTIOXIDANT; CGMP DEPENDENT PROTEIN KINASE IALPHA; CGMP-DEPENDENT PROTEIN KINASE IALPHA; DRUG DERIVATIVE; GLUTATHIONE PEROXIDASE; ISOENZYME; NUCLEOTIDE; OXIDIZING AGENT; OXIDOREDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GEL ELECTROPHORESIS; GENE CONTROL; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; ENDOTHELIUM CELL; INTRACELLULAR MEMBRANE; LUNG; METABOLISM; MICROVASCULATURE; MOUSE MUTANT; PATHOPHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; ANTIOXIDANTS; ATRIAL NATRIURETIC FACTOR; CATALASE; CELL DEATH; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; INTRACELLULAR MEMBRANES; ISOENZYMES; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROVESSELS; OXIDANTS; OXIDOREDUCTASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIONUCLEOTIDES;

EID: 77956678061     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00442.2009     Document Type: Article

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