Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 18, 2010, Pages 10020-10026

  Yang, Jung Mu ^a,b   Hung, Chao Ming ^c   Fu, Chen Nan ^d   Lee, Jang Chang ^e   Huang, Chi Hung ^f   Yang, Muh Hwa ^g,h   Lin, Chih Li ⁱ   Kao, Jung Yie ^a   Way, Tzong Der ^e  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b MINISTRY OF NATIONAL DEFENSE   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d Zuo Ying Armed Forces General Hospital   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f Taiwan Advance Biopharm Inc   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

^h TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

ⁱ CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

AMPK; Hispidulin; Mcl 1; Traditional Chinese medicine; TRAIL

Indexed keywords

AMPK; HISPIDULIN; MCL-1; TRADITIONAL CHINESE MEDICINE; TRAIL;

ANTIBIOTICS; DISEASES; LIGANDS; MAMMALS; SENSORS;

CELL DEATH;

ANTINEOPLASTIC AGENT; FLAVONE DERIVATIVE; HISPIDULIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; FEMALE; HUMAN; METABOLISM; OVARY TUMOR; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; DRUG SYNERGISM; ENZYME ACTIVATION; FEMALE; FLAVONES; HUMANS; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

MAMMALIA;

EID: 77956647039     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf102304g     Document Type: Article

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