Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient

Science Signaling

Volumn 3, Issue 136, 2010, Pages

  Casali, Andreu ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOGEN; PROTEIN PATCHED; SONIC HEDGEHOG PROTEIN;

ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE GROWTH;

ANIMALS; BODY PATTERNING; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 77956637831     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001059     Document Type: Article

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43. Acknowledgments: I am in special debt to G. Struhl and J. Casanova for ideas and support. I also thank A. Adachi (G. Struhl laboratory) and E. Caminero (Plataforma de Transformación de Drosophila, Consolider Ingenio 2007) for injections; G. Darras for the in situ hybridization; members of J. Casanova's laboratory for assistance and support; D. Rosell for help with statistical analysis; and K. Campbell, J. Casanova, J. Font, X. Franch-Marro, D. Shaye, M. Strigini, and G. Struhl for discussion and advice on the manuscript. This work was mostly done in J. Casanova's laboratory. Funding: Supported by the European commission (MIRG-CT-2007-44921) and the Spanish Ministerio de Educación y Ciencia (BFU2007-60663/BMC). Competing interests: The author declares that he has no competing interests.