메뉴 건너뛰기




Volumn 431, Issue 1, 2010, Pages 103-111

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

Author keywords

Lipoprotein receptor related protein (LRP); Megalin; Selenium deficiency; Selenium transport; Selenoprotein P (SePP); Trace element metabolism

Indexed keywords

BODY FLUIDS; BRAIN; LIVER; MAMMALS; METABOLISM; NUTRITION; PHYSIOLOGY; TRACE ELEMENTS;

EID: 77956626316     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100779     Document Type: Article
Times cited : (70)

References (45)
  • 1
    • 0036094506 scopus 로고    scopus 로고
    • How selenium has altered our understanding of the genetic code
    • Hatfield, D. L. and Gladyshev, V. N. (2002) How selenium has altered our understanding of the genetic code. Mol. Cell. Biol. 22, 3565-3576
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3565-3576
    • Hatfield, D.L.1    Gladyshev, V.N.2
  • 3
    • 77649267654 scopus 로고    scopus 로고
    • Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies
    • Conrad, M. and Schweizer, U. (2010) Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies. Antioxid. Redox Signaling 12, 851-865
    • (2010) Antioxid. Redox Signaling , vol.12 , pp. 851-865
    • Conrad, M.1    Schweizer, U.2
  • 4
    • 0034662094 scopus 로고    scopus 로고
    • The importance of selenium to human health
    • Rayman, M. P. (2000) The importance of selenium to human health. Lancet 356, 233-241
    • (2000) Lancet , vol.356 , pp. 233-241
    • Rayman, M.P.1
  • 5
    • 23944498579 scopus 로고    scopus 로고
    • Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasis
    • Burk, R. F. and Hill, K. E. (2005) Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu. Rev. Nutr. 25, 215-235
    • (2005) Annu. Rev. Nutr. , vol.25 , pp. 215-235
    • Burk, R.F.1    Hill, K.E.2
  • 7
    • 0037337666 scopus 로고    scopus 로고
    • Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues
    • Schomburg, L., Schweizer, U., Holtmann, B., Flohé, L., Sendtner, M. and Köhrle, J. (2003) Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem. J. 370, 397-402
    • (2003) Biochem. J. , vol.370 , pp. 397-402
    • Schomburg, L.1    Schweizer, U.2    Holtmann, B.3    Flohé, L.4    Sendtner, M.5    Köhrle, J.6
  • 10
    • 34249654101 scopus 로고    scopus 로고
    • Apolipoprotein e receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis
    • Olson, G. E., Winfrey, V. P., Nagdas, S. K., Hill, K. E. and Burk, R. F. (2007) Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis. J. Biol. Chem. 282, 12290-12297
    • (2007) J. Biol. Chem. , vol.282 , pp. 12290-12297
    • Olson, G.E.1    Winfrey, V.P.2    Nagdas, S.K.3    Hill, K.E.4    Burk, R.F.5
  • 12
    • 34250024011 scopus 로고    scopus 로고
    • Deletion of apolipoprotein e receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed
    • Burk, R. F., Hill, K. E., Olson, G. E., Weeber, E. J., Motley, A. K., Winfrey, V. P. and Austin, L. M. (2007) Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J. Neurosci. 27, 6207-6211
    • (2007) J. Neurosci. , vol.27 , pp. 6207-6211
    • Burk, R.F.1    Hill, K.E.2    Olson, G.E.3    Weeber, E.J.4    Motley, A.K.5    Winfrey, V.P.6    Austin, L.M.7
  • 13
    • 0036607597 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor gene family: A cellular Swiss army knife?
    • Nykjaer, A. and Willnow, T. E. (2002) The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol. 12, 273-280
    • (2002) Trends Cell Biol. , vol.12 , pp. 273-280
    • Nykjaer, A.1    Willnow, T.E.2
  • 14
    • 0035997373 scopus 로고    scopus 로고
    • Lipoprotein receptors in the nervous system
    • Herz, J. and Bock, H. H. (2002) Lipoprotein receptors in the nervous system. Annu. Rev. Biochem 71, 405-434
    • (2002) Annu. Rev. Biochem , vol.71 , pp. 405-434
    • Herz, J.1    Bock, H.H.2
  • 16
    • 43749086257 scopus 로고    scopus 로고
    • Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells
    • Olson, G. E., Winfrey, V. P., Hill, K. E. and Burk, R. F. (2008) Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J. Biol. Chem. 283, 6854-6860
    • (2008) J. Biol. Chem. , vol.283 , pp. 6854-6860
    • Olson, G.E.1    Winfrey, V.P.2    Hill, K.E.3    Burk, R.F.4
  • 17
    • 19344362286 scopus 로고    scopus 로고
    • A focused and efficient genetic screening strategy in the mouse: Identification of mutations that disrupt cortical development
    • Zarbalis, K., May, S. R., Shen, Y., Ekker, M., Rubenstein, J. L. and Peterson, A. S. (2004) A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2, e219
    • (2004) PLoS Biol. , vol.2
    • Zarbalis, K.1    May, S.R.2    Shen, Y.3    Ekker, M.4    Rubenstein, J.L.5    Peterson, A.S.6
  • 18
    • 33751531897 scopus 로고    scopus 로고
    • Selenium-dependent pre- And posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues
    • DOI 10.1210/en.2006-0689
    • Riese, C., Michaelis, M., Mentrup, B., Götz, F., Köhrle, J., Schweizer, U. and Schomburg, L. (2006) Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues. Endocrinology 147, 5883-5892 (Pubitemid 44833505)
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5883-5892
    • Riese, C.1    Michaelis, M.2    Mentrup, B.3    Gotz, F.4    Kohrle, J.5    Schweizer, U.6    Schomburg, L.7
  • 19
    • 31144448148 scopus 로고    scopus 로고
    • Trace element analysis using a benchtop TXRF-spectrometer
    • Stosnach, H. (2005) Trace element analysis using a benchtop TXRF-spectrometer. Powder Diffraction 20, 141-145
    • (2005) Powder Diffraction , vol.20 , pp. 141-145
    • Stosnach, H.1
  • 22
    • 0037066752 scopus 로고    scopus 로고
    • Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus: Evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination
    • Ma, S., Hill, K. E., Caprioli, R. M. and Burk, R. F. (2002) Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus: evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination. J. Biol. Chem. 277, 12749-12754
    • (2002) J. Biol. Chem. , vol.277 , pp. 12749-12754
    • Ma, S.1    Hill, K.E.2    Caprioli, R.M.3    Burk, R.F.4
  • 25
    • 0028324029 scopus 로고
    • Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/α2MR, and the receptor-associated protein (RAP)
    • Zheng, G., Bachinsky, D. R., Stamenkovic, I., Strickland, D. K., Brown, D., Andres, G. and McCluskey, R. T. (1994) Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/α2MR, and the receptor-associated protein (RAP). J. Histochem. Cytochem. 42, 531-542
    • (1994) J. Histochem. Cytochem. , vol.42 , pp. 531-542
    • Zheng, G.1    Bachinsky, D.R.2    Stamenkovic, I.3    Strickland, D.K.4    Brown, D.5    Andres, G.6    McCluskey, R.T.7
  • 26
    • 59849112358 scopus 로고    scopus 로고
    • The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice
    • Carlson, B. A., Schweizer, U., Perella, C., Shrimali, R. K., Feigenbaum, L., Shen, L., Speransky, S., Floss, T., Jeong, S. J., Watts, J. et al. (2009) The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Biochem. J. 418, 61-71
    • (2009) Biochem. J. , vol.418 , pp. 61-71
    • Carlson, B.A.1    Schweizer, U.2    Perella, C.3    Shrimali, R.K.4    Feigenbaum, L.5    Shen, L.6    Speransky, S.7    Floss, T.8    Jeong, S.J.9    Watts, J.10
  • 28
    • 37549060636 scopus 로고    scopus 로고
    • Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein e receptor 2
    • Valentine, W. M., Abel, T. W., Hill, K. E., Austin, L. M. and Burk, R. F. (2008) Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2. J. Neuropathol. Exp. Neurol. 67, 68-77
    • (2008) J. Neuropathol. Exp. Neurol. , vol.67 , pp. 68-77
    • Valentine, W.M.1    Abel, T.W.2    Hill, K.E.3    Austin, L.M.4    Burk, R.F.5
  • 33
    • 67649311966 scopus 로고    scopus 로고
    • Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice
    • Renko, K., Hofmann, P. J., Stoedter, M., Hollenbach, B., Behrends, T., Köhrle, J., Schweizer, U. and Schomburg, L. (2009) Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. FASEB J. 23, 1758-1765
    • (2009) FASEB J. , vol.23 , pp. 1758-1765
    • Renko, K.1    Hofmann, P.J.2    Stoedter, M.3    Hollenbach, B.4    Behrends, T.5    Köhrle, J.6    Schweizer, U.7    Schomburg, L.8
  • 37
    • 0344541909 scopus 로고    scopus 로고
    • Analysis of the mouse selenoprotein P gene
    • Steinert, P., Bachner, D. and Flohé, L. (1998) Analysis of the mouse selenoprotein P gene. Biol. Chem. 379, 683-691
    • (1998) Biol. Chem. , vol.379 , pp. 683-691
    • Steinert, P.1    Bachner, D.2    Flohé, L.3
  • 40
    • 1542374665 scopus 로고    scopus 로고
    • Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency
    • Schweizer, U., Michaelis, M., Köhrle, J. and Schomburg, L. (2004) Efficient selenium transfer from mother to offspring in selenoprotein-P- deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency. Biochem. J. 378, 21-26
    • (2004) Biochem. J. , vol.378 , pp. 21-26
    • Schweizer, U.1    Michaelis, M.2    Köhrle, J.3    Schomburg, L.4
  • 41
    • 0347986900 scopus 로고    scopus 로고
    • Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene
    • Hill, K. E., Zhou, J., McMahan, W. J., Motley, A. K. and Burk, R. F. (2004) Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J. Nutr. 134, 157-161
    • (2004) J. Nutr. , vol.134 , pp. 157-161
    • Hill, K.E.1    Zhou, J.2    McMahan, W.J.3    Motley, A.K.4    Burk, R.F.5
  • 43
    • 58249107850 scopus 로고    scopus 로고
    • Differential functions of the ApoER2 intracellular domain in selenium uptake and cell signaling
    • Masiulis, I., Quill, T. A., Burk, R. F. and Herz, J. (2009) Differential functions of the ApoER2 intracellular domain in selenium uptake and cell signaling. Biol. Chem. 390, 67-73
    • (2009) Biol. Chem. , vol.390 , pp. 67-73
    • Masiulis, I.1    Quill, T.A.2    Burk, R.F.3    Herz, J.4
  • 45
    • 70149107883 scopus 로고    scopus 로고
    • Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: A putative model for Kashin-Beck disease
    • Downey, C. M., Horton, C. R., Carlson, B. A., Parsons, T. E., Hatfield, D. L., Hallgrimsson, B. and Jirik, F. R. (2009) Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. PLoS Genet. 5, e1000616
    • (2009) PLoS Genet. , vol.5
    • Downey, C.M.1    Horton, C.R.2    Carlson, B.A.3    Parsons, T.E.4    Hatfield, D.L.5    Hallgrimsson, B.6    Jirik, F.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.