Brainstem axonal degeneration in mice with deletion of selenoprotein P

Toxicologic Pathology

Volumn 33, Issue 5, 2005, Pages 570-576

  Valentine, William M ^a,c   Hill, Kristina E ^a   Austin, Lori M ^a   Valentine, Holly L ^a   Goloowitz, Daniel ^b   Burk, Raymond F ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Axonal degeneration; Axonal dystrophy; Axonal transport; Selenium deficiency; Selenoprotein P; Spasticity

Indexed keywords

SELENIUM; SELENOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CERVICAL SPINAL CORD; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON MICROSCOPY; GENE DELETION; HISTOCHEMISTRY; HISTOLOGY; LIPID PEROXIDATION; MALE; MICROSCOPY; MOTOR DYSFUNCTION; MOUSE; NERVE FIBER DEGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SELENIUM DEFICIENCY;

ANIMALS; AXONS; BRAIN STEM; GENE DELETION; INBREEDING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SELENIUM;

ANIMALIA;

EID: 26944499813     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230500243045     Document Type: Article

References (16)

1. Behne, D., Hilmert, H., Scheid, S., Gessner, H., and Elger, W. (1988). Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta 966, 12-21.
2. Burk, R. F., and Hill, K. E. (2005). Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr 25, 215-235.
3. Burk, R. F., Hill, K. E., Read, R., and Bellew, T. (1991). Response of rat selenoprotein P to selenium administration and fate of its selenium. Am J Physiol 261, E26-E30.
4. Chan, S. Y., Worth, R., and Ochs, S. (1980). Block of axoplasmic transport in vitro by vinca alkaloids. J Neurobiol 11(3), 251-64.
5. Cho, E. S., Lowndes, H. E., and Goldstein, B. D. (1983). Neurotoxicology of vincristine in the cat. Morphological study. Arch Toxicol 52(2), 83-90.
6. Hill, K. E., Zhou, J., McMahan, W. J., Motley, A. K., Atkins, J. F., Gesteland, R. F., and Burk, R. F. (2003). Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem 278, 13640-6.
7. Hill, K. E., Zhou, J., McMahan, W. J., Motley, A. K., and Burk, R. F. (2004). Neurological dysfunction occurs in mice with targeted deletion of selenoprotein P gene. J Nutr 134, 157-61.
8. Johnson, D. J., Graham, D. G., Amarnath, V., Amarnath, K., and Valentine, W. M. (1998). Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N,N-diethyldithiocarbamate. Toxicol Appl Pharmacol 148(2), 288-96.
9. Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigo, R., and Gladyshev, V. N. (2003). Characterization of mammalian selenoproteomes. Science 300(5624), 1439-43.
10. 2-isoprostanes) in carbon tetrachloride hepatotoxicity, an animal model of lipid peroxidation. J Clin Invest 90, 2502-7.
11. Nukada, H., and Dyck, P. J. (1987). Acute ischemia causes axonal stasis, swelling, attenuation, and secondary demyelination. Ann Neurol 22(3), 311-8.
12. Patton, G. M., and Robins, S. J. (1990). Extraction and analysis of phospholipid molecular species. Meth Enzymol 187, 195-215.
13. Saijoh, K., Saito, N., Lee, M. J., Fujii, M., Kobayashi, T., and Sumino, K. (1995). Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression. Mol Brain Res 30, 301-11.
14. Schomburg, L., Schweizer, U., Holtmann, B., Flohé, L., Sendtner, M., and Kohrle, J. (2003). Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J 370(Pt 2), 397-402.
15. Southam, E., Thomas, P. K., King, R. H. M., Goss-Sampson, M. A., and Muller, D. P. R. (1991). Experimental vitamin E deficiency in rats. Morphological and functional evidence of abnormal axonal transport secondary to free radical damage. Brain 114, 915-36.
16. Yang, X., Hill, K. E., Maguire, M. J., and Burk, R. F. (2000). Synthesis and secretion of selenoprotein P by cultured rat astrocytes. Biochim Biophys Acta 1474, 390-6.