ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain

Current Biology

Volumn 16, Issue 24, 2006, Pages 2446-2452

  Beffert, Uwe ^a   Nematollah Farsian, Farnas ^b   Masiulis, Irene ^a   Hammer, Robert E ^a   Yoon, Sung Ok ^c   Giehl, Klaus M ^b   Herz, Joachim ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

MOLNEURO

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E RECEPTOR 2; LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 10;

AGING; ALTERNATIVE RNA SPLICING; ANIMAL; ARTICLE; BRAIN; CELL DEATH; CELL SURVIVAL; CYTOLOGY; EXON; GENETICS; MOUSE; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AGING; ALTERNATIVE SPLICING; ANIMALS; APOLIPOPROTEINS E; BRAIN; CELL DEATH; CELL SURVIVAL; EXONS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 10; NEURONS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LIPOPROTEIN;

EID: 33845384160     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.10.029     Document Type: Article

References (26)

1. Raber J., Huang Y., and Ashford J.W. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol. Aging 25 (2004) 641-650
2. Bonatz H., Rohrig S., Mestres P., Meyer M., and Giehl K.M. An axotomy model for the induction of death of rat and mouse corticospinal neurons in vivo. J. Neurosci. Methods 100 (2000) 105-115
3. O'Leary D.D., and Koester S.E. Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex. Neuron 10 (1993) 991-1006
4. Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J., Stockinger W., Nimpf J., Hammer R.E., Richardson J.A., and Herz J. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97 (1999) 689-701
5. Oudega M., Varon S., and Hagg T. Distribution of corticospinal motor neurons in the postnatal rat: Quantitative evidence for massive collateral elimination and modest cell death. J. Comp. Neurol. 347 (1994) 115-126
6. Beffert U., Durudas A., Weeber E.J., Stolt P.C., Giehl K.M., Sweatt J.D., Hammer R.E., and Herz J. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: Distinct roles in development and synaptic plasticity. J. Neurosci. 26 (2006) 2041-2052
7. Beffert U., Weeber E.J., Durudas A., Qiu S., Masiulis I., Sweatt J.D., Li W.P., Adelmann G., Frotscher M., Hammer R.E., et al. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 47 (2005) 567-579
8. Herz J., and Bock H.H. Lipoprotein receptors in the nervous system. Annu. Rev. Biochem. 71 (2002) 405-434
9. Arnaud L., Ballif B.A., Forster E., and Cooper J.A. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr. Biol. 13 (2003) 9-17
10. Ballif B.A., Arnaud L., and Cooper J.A. Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Res. Mol. Brain Res. 117 (2003) 152-159
11. Beffert U., Morfini G., Bock H.H., Reyna H., Brady S.T., and Herz J. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J. Biol. Chem. 277 (2002) 49958-49964
12. Bock H.H., and Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr. Biol. 13 (2003) 18-26
13. Chen Y., Beffert U., Ertunc M., Tang T.S., Kavalali E.T., Bezprozvanny I., and Herz J. Reelin modulates NMDA receptor activity in cortical neurons. J. Neurosci. 25 (2005) 8209-8216
14. Brandes C., Kahr L., Stockinger W., Hiesberger T., Schneider W.J., and Nimpf J. Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J. Biol. Chem. 276 (2001) 22160-22169
15. Gotthardt M., Trommsdorff M., Nevitt M.F., Shelton J., Richardson J.A., Stockinger W., Nimpf J., and Herz J. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem. 275 (2000) 25616-25624
16. Stockinger W., Brandes C., Fasching D., Hermann M., Gotthardt M., Herz J., Schneider W.J., and Nimpf J. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J. Biol. Chem. 275 (2000) 25625-25632
17. Yang D.D., Kuan C.Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., and Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 (1997) 865-870
18. Namgung U., and Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20 (2000) 6442-6451
19. Kuan C.Y., Whitmarsh A.J., Yang D.D., Liao G., Schloemer A.J., Dong C., Bao J., Banasiak K.J., Haddad G.G., Flavell R.A., et al. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl. Acad. Sci. USA 100 (2003) 15184-15189
20. Hoe H.S., Pocivavsek A., Chakraborty G., Fu Z., Vicini S., Ehlers M.D., and Rebeck G.W. Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J. Biol. Chem. 281 (2006) 3425-3431
21. Chao M.V. Neurotrophins and their receptors: A convergence point for many signalling pathways. Nat. Rev. Neurosci. 4 (2003) 299-309
22. Lutz C., Nimpf J., Jenny M., Boecklinger K., Enzinger C., Utermann G., Baier-Bitterlich G., and Baier G. Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). J. Biol. Chem. 277 (2002) 43143-43151
23. May P., Bock H.H., Nimpf J., and Herz J. Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J. Biol. Chem. 278 (2003) 37386-37392
24. Lo E.H., Wang X., and Cuzner M.L. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J. Neurosci. Res. 69 (2002) 1-9
25. Giehl K., and Mestres P. Somatostatin-mRNA expression in brainstem projections into the medial preoptic nucleus. Exp. Brain Res. 103 (1995) 344-354
26. Harrington A.W., Leiner B., Blechschmitt C., Arevalo J.C., Lee R., Morl K., Meyer M., Hempstead B.L., Yoon S.O., and Giehl K.M. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc. Natl. Acad. Sci. USA 101 (2004) 6226-6230