How selenium has altered our understanding of the genetic code

Molecular and Cellular Biology

Volumn 22, Issue 11, 2002, Pages 3565-3576

  Hatfield, Dolph L ^a   Gladyshev, Vadim N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; SELENIUM; SELENOCYSTEINE; TRANSFER RNA;

3' UNTRANSLATED REGION; AMINO ACID SYNTHESIS; GENE INSERTION; GENETIC CODE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE; SHORT SURVEY; STOP CODON; TRANSGENE;

ANIMALS; BASE SEQUENCE; CODON; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENETIC CODE; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEINS; RNA, TRANSFER, AMINO ACYL; SELENIUM; SELENOCYSTEINE; SELENOPROTEINS;

INSERTION SEQUENCES; MAMMALIA;

EID: 0036094506     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.11.3565-3576.2002     Document Type: Short Survey

References (103)

1. Selenocysteine synthesis in mammalia: An identity switch from tRNA(Ser) to tRNA(Sec)
2. Editing does not exist for mammalian selenocysteine tRNAs
3. Role of selenium in HIV/AIDS
4. Selenium as an antiviral agent
5. Evidence for specific selenium target tissues and new biologically important selenoproteins
6. Selenocysteine insertion or termination factors affecting UGA codon fate and complementary anticodon: Codon mutations
7. Selenium metabolism in bacteria
8. Selenoprotein synthesis: An expansion of the genetic code
9. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)
10. Mammalian selenocysteine tRNA
11. In silico identification of novel selenoproteins in the Drosophila melanogaster genome
12. Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm
13. The structure of the mouse glutathione peroxidase gene: The selenocysteine in the active site is encoded by the 'termination' codon, TGA
14. [Ser]Sec gene
15. Replenishment of selenium deficient rats with selenium results in redistribution of the selenocysteine tRNA population in a tissue specific manner
16. Rabbit β-globin is extended beyond its UGA stop codon by multiple suppressions and translation reading gaps
17. Reconstitution of the biosynthetic pathway of selenocysteine tRNAs in Xenopus oocytes
18. Dietary selenium stabilized glutathione peroxidase mRNA in rat liver
19. Selenium as a cancer preventive agent
20. Purification, redox sensitivity, and RNA binding properties of SECIS-binding protein 2, a protein involved in selenoprotein biosynthesis
21. Insight into mammalian selenocysteine insertion: Domain structure and ribosome binding properties of Sec insertion sequence binding protein 2
22. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs
23. Selenium deficiency and human disease
24. Structure and properties of a bovine liver UGA suppressor serine tRNA with a tryptophan anticodon
25. Selenocysteine inserting tRNAs are likely generated by tRNA editing
26. [Ser]Sec
27. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation
28. Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: Evidence for a block in elongation at the UGA/selenocysteine codon
29. The selenocysteine incorporation machinery: Interactions between the SECIS RNA and the SECIS-binding protein SBP2
30. Selenium and male reproduction
31. Selenium in biology and human health: Controversies and perspectives
32. Nicotinic acid hydroxylase from Clostridium barkeri: Electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme
33. Evolution of selenocysteine-containing proteins: Significance of identification and functional characterization of selenoproteins
34. Monoselenophosphate: Synthesis, characterization, and identity with the prokaryotic biological selenium donor, compound SePX
35. Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes
36. Interplay between termination and translation machinery in eukaryotic selenoprotein synthesis
37. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: Is there an autoregulatory mechanism in selenocysteine metabolism?
38. Seryl-tRNA in mammalian tissues. Chromatographic differences in brain and liver and a specific response to the codon, UGA
39. Opal suppressor serine tRNAs from bovine liver form phosphoseryl-tRNA
40. [Ser]Sec population in mammal cells
41. Selenocysteine tRNA(Ser)sec isoacceptors as central components in selenoprotein biosynthesis in eukaryotes
42. Biosynthesis of selenocysteine and its incorporation into protein as the 21st amino acid
43. Coding from a distance: Dissection of the mRNA determinants required for the incorporation of selenocysteine into protein
44. Differential regulation of rat liver selenoprotein mRNAs in selenium deficiency
45. Effect of selenium on selenoprotein P expression in cultured liver cells
46. The 9/4 secondary structure of eukaryotic selenocysteine tRNA: More pieces of evidence
47. Modeling the tertiary interactions in the eukaryotic selenocysteine tRNA
48. Polynucleotide synthesis and the genetic code
49. Selenophosphate synthetase: Detection in extracts of rat tissues by immunoblot assay and partial purification of the enzyme from the archaean Methanococcus vannielii
50. [Ser]Sec is governed by both primary and tertiary structure
51. The deiodinase family: Selenoenzymes regulating thyroid hormone availability and action
52. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element
53. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements
54. Selenoprotein R is a zinc-containing stereospecific methionine sulfoxide reductase
55. Ser in mammalian cells which recognizes the nonsense codon, UGA
56. Unique pathway of expression of an opal suppressor phosphoserine tRNA
57. Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity
58. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium
59. Occurrence in vivo of selenocysteyl-tRNA(SERUGA) in Escherichia coli. Effect of sel mutations
60. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif
61. UGA can be decoded as tryptophan at low efficiency in Bacillus subtilis
62. Knowing when not to stop: Selenocysteine incorporation in eukaryotes
63. Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis
64. SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy
65. Mass spectrometric characterization of full-length rat selenoprotein P and 3 isoforms shortened at the C terminus. Evidence that 3 UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination
66. Selenocysteine codons decrease polysome association on endogenous selenoprotein mRNAs
67. Selenium metabolism in Drosophila: Selenoproteins, selenoprotein mRNA expression, fertility, and mortality
68. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
69. Translational termination efficiency in mammals is influenced by the base following the stop codon
70. Effects of selenium on immunity and aging
71. UGA is translated as cysteine in pheromone 3 of Euplotes octocarinatus
72. Selenium and iodine deficiencies: Effects on brain and brown adipose tissue selenoenzyme activity and expression
73. Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA
74. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
75. [Ser]Sec gene
76. Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA
77. Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases
78. Eukaryotic selenocysteine incorporation follows a non-processive mechanism that competes with translational termination
79. The RNA code in protein synthesis
80. Selenocysteine tRNA and serine tRNA are aminoacylated by the same synthetase, but may manifest different identities with respect to the long extra arm
81. Recent evidence for evolution of the genetic code
82. Heterologous expression of archaeal selenoprotein genes directed by the SECIS element located in the 3′ non-translated region
83. Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver
84. Selenocysteine
85. cDNA sequence coding for human glutathione peroxidase
86. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases
87. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems
88. Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position
89. Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues
90. Serine incorporation into the selenocysteine moiety of glutathione peroxidase
91. Role of low molecular weight, selenium-containing compounds in human health
92. Decoding apparatus for eukaryotic selenocysteine insertion
93. Domain-specific recruitment of amide amino acids for protein synthesis
94. A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs
95. tRNA sequences and variations in the genetic code
96. A single UGA codon functions as a natural termination signal in the coliphage beta coat protein cistron
97. cis-Acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels
98. Peptide methionine sulfoxide reductase: Structure, mechanism of action, and biological function
99. [Ser]Sec and tRNA(Ser) function as major identity elements for serylation in an orientation-dependent, but not sequence-specific manner
100. [Ser]Sec genes
101. [Ser]Sec gene in Chinese hamsters
102. Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
103. Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogen-lyase-linked) from Escherichia coli