Rapid, mild method for phosphonate diester hydrolysis: Development of a one-pot synthesis of tenofovir disoproxil fumarate from tenofovir diethyl ester

Tetrahedron

Volumn 66, Issue 41, 2010, Pages 8137-8144

  Houghton, Stephen R ^a   Melton, Jack ^b   Fortunak, Joseph ^c   Brown Ripin, David H ^d   Boddy, Christopher N ^a,e  

^a SYRACUSE UNIVERSITY   (United States)

^b ProcesScience Inc   (United States)

^c HOWARD UNIVERSITY   (United States)

^d CLINTON HEALTH ACCESS INITIATIVE   (United States)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Phosphoate ester hydrolysis; Tenofovir; TMSBr

Indexed keywords

ALENDRONIC ACID; FUMARIC ACID DERIVATIVE; LEWIS ACID; PHOSPHONIC ACID DERIVATIVE; RISEDRONIC ACID; SODIUM BROMIDE; TENOFOVIR DISOPROXIL;

ALKYLATION; ARTICLE; DRUG HYDROLYSIS; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROLYSIS; LOW TEMPERATURE; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 77956613658     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.08.037     Document Type: Article

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