S-alkylated homocysteine derivatives: New inhibitors of human betaine-homocysteine S-methyltransferase

Journal of Medicinal Chemistry

Volumn 49, Issue 13, 2006, Pages 3982-3989

  Jiracek, Jiri ^a   Collinsova, Michaela ^a   Rosenberg, Ivan ^a   Budesinsky, Milos ^a   Protivinska, Eva ^a   Netusilova, Hana ^a   Garrow, Timothy A ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (3 CARBOXYMETHYLSULFANYLETHYLSULFANYL)BUTYRIC ACID; 5 (3 AMINO 3 CARBOXYPROPYLSULFANYL)PENTANOIC ACID; 6 (3 AMINO 3 CARBOXYPROPYLSULFANYL)HEXANOIC ACID; AMINO ACID DERIVATIVE; BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; HOMOCYSTEINE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION;

BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; BUTYRIC ACIDS; HEXANOIC ACIDS; HOMOCYSTEINE; HUMANS; PENTANOIC ACIDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 33745662826     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050885v     Document Type: Article

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