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Volumn 66, Issue 41, 2010, Pages 8175-8180

Regioselective addition reactions at C-2 of 3,4-dihydropyrimidinones. Synthesis and evaluation of multifunctionalized tetrahydropyrimidines

(3) Singh, Kamaljit a Arora, Divya a Balzarini, Jan b

a GURU NANAK DEV UNIVERSITY (India)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

Biginelli compounds; Carbon nucleophiles; Desulfurization; Pyrimidines; Regioselectivity

Indexed keywords

3,4 DIHYDROPYRIMIDINONE DERIVATIVE; CHLOROFORMIC ACID ETHYL ESTER; NUCLEOPHILE; PYRIMIDINONE DERIVATIVE; TETRAHYDROPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIGINELLI REACTION; BREAST CARCINOMA; CHEMICAL REACTION; CONTROLLED STUDY; DESULFURIZATION; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN; HUMAN TISSUE; LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; UTERINE CERVIX CARCINOMA;

EID: 77956611044 PISSN: 00404020 EISSN: None Source Type: Journal
DOI: 10.1016/j.tet.2010.08.034 Document Type: Article

Times cited : (17)

References (34)

1
- 33847381100
- P.J. Hajduk, and J. Greer Nat. Rev. Drug Discovery 6 2007 211 219
- (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 211-219
- Hajduk, P.J.¹ Greer, J.²

2
- 0026065919
- K.S. Atwal, B.N. Swanson, S.E. Unger, D.M. Floyd, S. Moreland, A. Hedberg, and B.C. O'Reilly J. Med. Chem. 34 1991 806 811
- (1991) J. Med. Chem. , vol.34 , pp. 806-811
- Atwal, K.S.¹ Swanson, B.N.² Unger, S.E.³ Floyd, D.M.⁴ Moreland, S.⁵ Hedberg, A.⁶ O'Reilly, B.C.⁷

3
- 0033615357
- T.U. Mayer, T.M. Kapoor, S.J. Haggarty, R.W. King, S.L. Schreiber, and T.J. Mitchison Science 286 1999 971 974
- (1999) Science , vol.286 , pp. 971-974
- Mayer, T.U.¹ Kapoor, T.M.² Haggarty, S.J.³ King, R.W.⁴ Schreiber, S.L.⁵ Mitchison, T.J.⁶

4
- 0034177962
- S.J. Haggarty, T.U. Mayer, D.T. Miyamoto, R. Fathi, R.W. King, T.J. Mitchison, and S.L. Schreiber Chem. Biol. 7 2000 275 286
- (2000) Chem. Biol. , vol.7 , pp. 275-286
- Haggarty, S.J.¹ Mayer, T.U.² Miyamoto, D.T.³ Fathi, R.⁴ King, R.W.⁵ Mitchison, T.J.⁶ Schreiber, S.L.⁷

5
- 0036752261
- Z. Maliga, T.M. Kapoor, and T.J. Mitchison Chem. Biol. 9 2002 989 996
- (2002) Chem. Biol. , vol.9 , pp. 989-996
- Maliga, Z.¹ Kapoor, T.M.² Mitchison, T.J.³

6
- 0037457808
- S. DeBonis, J.P. Simorre, I. Crevel, L. Lebeau, D.A. Skoufias, A. Blangy, C. Ebel, P. Gans, R. Cross, D.D. Hackney, R.H. Wade, and F. Kozielski Biochemistry 42 2003 338 349
- (2003) Biochemistry , vol.42 , pp. 338-349
- Debonis, S.¹ Simorre, J.P.² Crevel, I.³ Lebeau, L.⁴ Skoufias, D.A.⁵ Blangy, A.⁶ Ebel, C.⁷ Gans, P.⁸ Cross, R.⁹ Hackney, D.D.¹⁰ Wade, R.H.¹¹ Kozielski, F.¹²

7
- 18544397955
- J.C. Barrow, P.G. Nantermet, H.G. Selnick, K.L. Glass, K.E. Rittle, K.F. Gilbert, T.G. Steele, C.F. Homnick, R.M. Freidinger, R.W. Ransom, P. Kling, D. Reiss, T.P. Broten, T.W. Schorn, R.S.L. Chang, S. O'Malley, T.V. Olah, J.D. Ellis, A. Barrish, K. Kassahun, P. Leppert, D. Nagarathnam, and C. Forray J. Med. Chem. 43 2000 2703 2718
- (2000) J. Med. Chem. , vol.43 , pp. 2703-2718
- Barrow, J.C.¹ Nantermet, P.G.² Selnick, H.G.³ Glass, K.L.⁴ Rittle, K.E.⁵ Gilbert, K.F.⁶ Steele, T.G.⁷ Homnick, C.F.⁸ Freidinger, R.M.⁹ Ransom, R.W.¹⁰ Kling, P.¹¹ Reiss, D.¹² Broten, T.P.¹³ Schorn, T.W.¹⁴ Chang, R.S.L.¹⁵ O'Malley, S.¹⁶ Olah, T.V.¹⁷ Ellis, J.D.¹⁸ Barrish, A.¹⁹ Kassahun, K.²⁰ more..

8
- 0347928672
- K. Deres, C.H. Schroeder, A. Paessens, S. Goldmann, H.J. Hacker, O. Weber, T. Kramer, U. Niewoehner, U. Pleiss, J. Stoltefuss, E. Graef, D. Koletzki, R.N.A. Masantschek, A. Reimann, R. Jaeger, R. Grob, B. Beckermann, K.-H. Schlemmer, D. Haebich, and H. Ruebsamen-Waigmann Science 299 2003 893 896
- (2003) Science , vol.299 , pp. 893-896
- Deres, K.¹ Schroeder, C.H.² Paessens, A.³ Goldmann, S.⁴ Hacker, H.J.⁵ Weber, O.⁶ Kramer, T.⁷ Niewoehner, U.⁸ Pleiss, U.⁹ Stoltefuss, J.¹⁰ Graef, E.¹¹ Koletzki, D.¹² Masantschek, R.N.A.¹³ Reimann, A.¹⁴ Jaeger, R.¹⁵ Grob, R.¹⁶ Beckermann, B.¹⁷ Schlemmer, K.-H.¹⁸ Haebich, D.¹⁹ Ruebsamen-Waigmann, H.²⁰ more..

9
- 0034519777
- C.O. Kappe Eur. J. Med. Chem. 35 2000 1043 1052
- (2000) Eur. J. Med. Chem. , vol.35 , pp. 1043-1052
- Kappe, C.O.¹

10
- 77956612970
- K. Singh, D. Arora, K. Singh, and S. Singh Mini-Rev. Med. Chem. 99 2009 5 106
- (2009) Mini-Rev. Med. Chem. , vol.99 , pp. 5-106
- Singh, K.¹ Arora, D.² Singh, K.³ Singh, S.⁴

11
- 14644388180
- D. Dallinger, and C.O. Kappe Pure Appl. Chem. 77 2005 155 161
- (2005) Pure Appl. Chem. , vol.77 , pp. 155-161
- Dallinger, D.¹ Kappe, C.O.²

12
- 22244435902
- K. Singh, S. Singh, and A. Mahajan J. Org. Chem. 70 2005 6114 6117
- (2005) J. Org. Chem. , vol.70 , pp. 6114-6117
- Singh, K.¹ Singh, S.² Mahajan, A.³

13
- 33749506704
- K. Singh, and S. Singh Tetrahedron Lett. 47 2006 8143 8146
- (2006) Tetrahedron Lett. , vol.47 , pp. 8143-8146
- Singh, K.¹ Singh, S.²

14
- 70350714960
- K. Singh, and K. Singh Tetrahedron 65 2009 10395 10399
- (2009) Tetrahedron , vol.65 , pp. 10395-10399
- Singh, K.¹ Singh, K.²

15
- 67650895373
- K. Singh, D. Arora, D. Falkowaski, Q. Liu, and R.S. Moreland Eur. J. Org. Chem. 2009 3258 3264
- (2009) Eur. J. Org. Chem. , pp. 3258-3264
- Singh, K.¹ Arora, D.² Falkowaski, D.³ Liu, Q.⁴ Moreland, R.S.⁵

16
- 33846339316
- K. Singh, D. Arora, and S. Singh Tetrahedron Lett. 48 2007 1349 1352
- (2007) Tetrahedron Lett. , vol.48 , pp. 1349-1352
- Singh, K.¹ Arora, D.² Singh, S.³

17
- 64649085011
- K. Singh, and S. Singh Tetrahedron 65 2009 4106 4112
- (2009) Tetrahedron , vol.65 , pp. 4106-4112
- Singh, K.¹ Singh, S.²

18
- 20444421508
- S.J. Stray, C.R. Bourne, S. Punna, W.G. Lewis, M.G. Finn, and A.Z. Zlotnick PNAS 10 2005 8138 8143
- (2005) PNAS , vol.10 , pp. 8138-8143
- Stray, S.J.¹ Bourne, C.R.² Punna, S.³ Lewis, W.G.⁴ Finn, M.G.⁵ Zlotnick, A.Z.⁶

19
- 0022178434
- A. Kreutzberger, and M. Sellheim J. Heterocycl. Chem. 22 1985 721 723
- (1985) J. Heterocycl. Chem. , vol.22 , pp. 721-723
- Kreutzberger, A.¹ Sellheim, M.²

20
- 0031081522
- M. Watanabe, H. Koike, T. Ishiba, T. Okada, S. Seo, and K. Hirai Bioorg. Med. Chem. 5 1997 437 444
- (1997) Bioorg. Med. Chem. , vol.5 , pp. 437-444
- Watanabe, M.¹ Koike, H.² Ishiba, T.³ Okada, T.⁴ Seo, S.⁵ Hirai, K.⁶

21
- 0036635291
- R. Capdeville, E. Buchdunger, J. Zimmermann, and A. Matter Nat. Rev. Drug Discovery 1 2002 493 502
- (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 493-502
- Capdeville, R.¹ Buchdunger, E.² Zimmermann, J.³ Matter, A.⁴

22
- 77956613162
- note
- 50: 0.9 μg/mL and 1.2 μg/mL, respectively). Compound 7 was more cytotoxic (MCC: 4-10 μg/mL) to confluent cell cultures (i.e., human embryonic lung cells, feline Crandell kidney cells) than 8 (MCC: ≥100 μg/mL) in these cell cultures. Singh, K, Arora, D, Balzarini, J. unpublished results.

23
- 34047211881
- M. Matloobi, and C.O. Kappe J. Comb. Chem. 9 2007 275 284
- (2007) J. Comb. Chem. , vol.9 , pp. 275-284
- Matloobi, M.¹ Kappe, C.O.²

24
- 1642360667
- A. Lenger, and C.O. Kappe Org. Lett. 6 2004 771 774
- (2004) Org. Lett. , vol.6 , pp. 771-774
- Lenger, A.¹ Kappe, C.O.²

25
- 14544306016
- F.-A. Kang, J. Kodah, Q. Guan, X. Li, and W.V. Murray J. Org. Chem. 70 2005 1957 1960
- (2005) J. Org. Chem. , vol.70 , pp. 1957-1960
- Kang, F.-A.¹ Kodah, J.² Guan, Q.³ Li, X.⁴ Murray, W.V.⁵

26
- 51349108165
- A.R. Gholap, K.S. Toti, F. Shirazi, M.V. Deshpande, and K.V. Srinivasan Tetrahedron 64 2008 10214 10223
- (2008) Tetrahedron , vol.64 , pp. 10214-10223
- Gholap, A.R.¹ Toti, K.S.² Shirazi, F.³ Deshpande, M.V.⁴ Srinivasan, K.V.⁵

27
- 61349100776
- S. Singh, A. Schober, M. Gebinoga, and A.G. Gross Tetrahedron Lett. 50 2009 1838 1843
- (2009) Tetrahedron Lett. , vol.50 , pp. 1838-1843
- Singh, S.¹ Schober, A.² Gebinoga, M.³ Gross, A.G.⁴

28
- 37049105821
- C. Kashima, M. Shimizu, A. Katoh, and Y. Omote J. Chem. Soc., Perkin Trans. 1 1983 1799 1802
- (1983) J. Chem. Soc., Perkin Trans. 1 , pp. 1799-1802
- Kashima, C.¹ Shimizu, M.² Katoh, A.³ Omote, Y.⁴

29
- 0000176059
- P. Biginelli Gazz. Chim. Ital. 23 1893 360 416
- (1893) Gazz. Chim. Ital. , vol.23 , pp. 360-416
- Biginelli, P.¹

30
- 0032473839
- K. Singh, J. Singh, and H. Singh Tetrahedron 54 1998 3567 3574
- (1998) Tetrahedron , vol.54 , pp. 3567-3574
- Singh, K.¹ Singh, J.² Singh, H.³

31
- 0342868424
- E. Jones, and I.M. Moodie Org. Synth. Coll. Vol. 6 1988 979 980
- (1988) Org. Synth. , vol.6 , pp. 979-980
- Jones, E.¹ Moodie, I.M.²

32
- 0043266797
- G.S. Hiers Org. Synth. Coll. Vol. 1 1941 550 552
- (1941) Org. Synth. , vol.1 , pp. 550-552
- Hiers, G.S.¹

33
- 0028059761
- D.L. Comins, S.P. Joseph, and R.R. Goehring J. Am. Chem. Soc. 116 1994 4719 4728
- (1994) J. Am. Chem. Soc. , vol.116 , pp. 4719-4728
- Comins, D.L.¹ Joseph, S.P.² Goehring, R.R.³

34
- 4644229467
- U. Jacquemard, V. Beneteau, M. Lefoix, S. Routeir, J.-Y. Merour, and G. Coudert Tetrahedron 60 2004 10039 10047
- (2004) Tetrahedron , vol.60 , pp. 10039-10047
- Jacquemard, U.¹ Beneteau, V.² Lefoix, M.³ Routeir, S.⁴ Merour, J.-Y.⁵ Coudert, G.⁶

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