Free radicals, antioxidants and eye diseases: Evidence from epidemiological studies on cataract and age-related macular degeneration

Ophthalmic Research

Volumn 44, Issue 3, 2010, Pages 191-198

  Fletcher, A E ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Age related cataract; Age related macular degeneration; Free radicals

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAROTENOID; FREE RADICAL; XANTHOPHYLL; ZINC;

BIOMASS; CATARACT; CIGARETTE SMOKING; HUMAN; LENS; LIGHT EXPOSURE; MITOCHONDRION; PRIORITY JOURNAL; RETINA; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RISK FACTOR; SMOKING; SUNLIGHT;

ANTIOXIDANTS; CATARACT; EYE DISEASES; FREE RADICALS; HUMANS; MACULAR DEGENERATION; REACTIVE OXYGEN SPECIES;

EID: 77956597841     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000316476     Document Type: Review

References (71)

1. Resnikoff S, et al.: Global data on visual impairment in the year 2002. Bull World Health Organ 2004; 82: 844-851.
2. Congdon N, et al.: Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 2004; 122: 487-494.
3. Murthy GV, et al.: Prevalence of lens opacities in North India: the INDEYE feasibility study. Invest Ophthalmol Vis Sci 2007; 48: 88-95.
4. Augood CA, et al.: Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthal-mol 2006; 124: 529-535.
5. Klein R, Klein BE, Linton KL: Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 1992; 99: 933-943.
6. Vingerling JR, et al.: The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology 1995; 102:205-210.
7. Congdon N, et al.: Causes and prevalence of visual impairment among adults in the United States. Arch Opthalmol 2004; 122:477-485.
8. Fletcher AE, et al.: Sunlight exposure, anti-oxidants, and age-related macular degeneration. Arch Ophtha lmol 2008; 126: 1396-1403.
9. Winkler BS, et al.: Oxidative damage and age-related macular degeneration. Mol Vis 1999; 5:32.
10. Berthoud VM, Beyer EC: Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal 2009; 11:339-353.
11. Stitt AW: Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br J Ophthalmol 2001; 85: 74 6-753.
12. Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11:298-300.
13. Harman D: The biologic clock: the mitochondria? J Am Geriatr Soc 1972; 20:14 5-147.
14. Muller FL, et al.: Trends in oxidative aging theories. Free Radic Biol Med 2007; 43:477-503.
15. Balaban RS, Nemoto S, Finkel T: Mitochondria, oxidants, and aging. Cell 2005; 120: 483-495.
16. Kujoth GC, et al.: The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet 2007; 3:e24.
17. 10 as a potential treatment. J Bioenerg Biomembr 2004; 36:381-386.
18. Brennan LA, Kantorow M: Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res 2009; 88: 19 5-2 0 3.
19. Jarrett SG, et al.: Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retinal Eye Res 2008; 27: 596-607.
20. Canter JA, et al.: Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS One 2008; 3:e2091.
21. San Giovanni JP, et al.: Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration. PLoS One 2009; 4:e5508.
22. Udar N, et al.: Mitochondrial DNA hap-logroups associated with age-related macu-lar degeneration. Invest Ophthalmol Vis Sci 2009; 50:2966-2974.
23. Redman LM, et al.: Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One 2009; 4:e4377.
24. Nirmalan PK, et al.: Risk factors for age related cataract in a rural population of southern India: the Aravind Comprehensive Eye Study. Br J Ophthalmol 2004; 88:989-994.
25. Dherani M, et al.: Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. Invest Ophthalmol Vis Sci 2008; 49: 3328-3335.
26. Weintraub JM, et al.: A prospective study of the relationship between body mass index and cataract extraction among US women and men. Int J Obes Relat Metab Disord 2002; 26: 1588-1595.
27. Klein R, et al.: Cardiovascular disease, its risk factors and treatment, and age-related mac-ular degeneration: Women's Health Initiative Sight Exam ancillary study. Am J Oph-thalmol 2007; 143:473-483.
28. Oliva MS, Taylor H: Ultraviolet radiation and the eye. Int Ophthalmol Clin 2005; 45: 1-17.
29. Varma SD: Ascorbic acid and the eye with special reference to the lens. Ann NY Acad Sci 1987; 498: 280-306.
30. 2. Free Radic Biol Med 2003; 34: 521-530.
31. Taylor A, Hobbs M: 2001 assessment of nutritional influences on risk for cataract. Nutrition 2001; 17:845-857.
32. Beatty S, et al.: Macular pigment and age related macular degeneration. Br J Ophthal-mol 1999; 83:867-877.
33. McCarty CA, Taylor HR: A review of the ep-idemiologic evidence linking ultraviolet radiation and cataracts. Dev Ophthalmol 2002; 35: 21-31.
34. Neale RE, et al.: Sun exposure as a risk factor for nuclear cataract. Epidemiology 2003; 14: 707-712.
35. Pastor-Valero M, et al.: Years of sunlight exposure and cataract: a case-control study in a Mediterranean population. BMC Ophthal-mol 20 07; 7: 18.
36. Taylor HR, et al.: The long-term effects of visible light on the eye. Arch Ophthalmol 1992; 110: 99-104.
37. Cruickshanks KJ, Klein R, Klein BE: Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthal-mol 1993; 111:514-518.
38. Delcourt C, et al.: Light exposure and the risk of age-related macular degeneration: the Pathologies Oculaires Liéés à l'Age (POLA) study. Arch Ophthalmol 2001; 119: 1463-14 68.
39. Darzins P, Mitchell P, Heller RF: Sun exposure and age-related macular degeneration: an Australian case-control study. Ophthalmology 1997; 104:770-776.
40. The Eye Disease Case-Control Study Group: Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 1992; 110:1701-1708.
41. Khan JC, et al.: Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight. Br J Ophthalmol 2006; 90:29-32.
42. Cruickshanks KJ, et al.: Sunlight and the 5-year incidence of early age-related macu-lopathy: the Beaver Dam Eye Study. Arch Ophthalmol 2001; 11 9: 246-250.
43. Bruce N, Perez-Padilla R, Albalak R: Indoor air pollution in developing countries: a major environmental and public health challenge. Bull World Health Organ 2000; 78: 1078-1092.
44. Mohan M, et al.: India-US case-control study of age-related cataracts. India-US Case-Control Study Group. Arch Ophthalmol 1989; 107:670-676.
45. Ughade SN, Zodpey SP, Khanolkar VA: Risk factors for cataract: a case control study. Indian J Ophthalmol 1998; 46:221-227.
46. Sreenivas V, et al.: A rural population based case-control study of senile cataract in India. J Epidemiol 1999; 9: 327-336.
47. Pokhrel AK, et al.: Case-control study of indoor cooking smoke exposure and cataract in Nepal and India. Int J Epidemiol 2005; 34: 702-708.
48. Shalini VK, et al.: Oxidative damage to the eye lens caused by cigarette smoke and fuel smoke condensates. Indian J Biochem Bio-phys 1994; 31:261-266.
49. Rao CM, et al.: Effect of smoke condensate on the physiological integrity and morphology of organ cultured rat lenses. Curr Eye Res 19 95; 14: 295-301.
50. Cong R, et al.: Smoking and the risk of age-related macular degeneration: a meta-analy-sis. Ann Epidemiol 20 08; 18: 647-656.
51. Kelly SP, et al.: Smoking and cataract: review of causal association. J Cataract Refract Surg 2005; 31: 2395-2404.
52. Krishnaiah S, et al.: Smoking and its association with cataract: results of the Andhra Pradesh eye disease study from India. Invest Ophthalmol Vis Sci 2005; 46: 58-65.
53. Raju P, et al.: Influence of tobacco use on cataract development. Br J Ophthalmol 2006; 90:1374-1377.
54. Dietrich M, et al.: Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase 7-tocopherol in vivo after adjustment for dietary antioxidant intakes. Am J Clin Nutr 2003; 77:160-166.
55. Ramakrishnan S, et al.: Smoking of beedies and cataract: cadmium and vitamin C in the lens and blood. Br J Ophthalmol 1995; 79: 202-206.
56. Chiu CJ, Taylor A: Nutritional antioxidants and age-related cataract and maculopathy. Exp Eye Res 2007; 84:229-245.
57. Van Leeuwen R, et al.: Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 2005; 294:3101-3107.
58. Seddon JM, et al.: Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 1994; 272:1413-1420.
59. Cho E, et al.: Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol 2004; 122:883-892.
60. Moeller SM, et al.: Overall adherence to the dietary guidelines for Americans is associated with reduced prevalence of early age-related nuclear lens opacities in women. J Nutr 2004; 134: 181 2-1819.
61. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report No 9. Arch Ophthalmol 2001; 119: 1439-1452.
62. McNeil JJ, et al.: Vitamin E supplementation and cataract: randomized controlled trial. Ophtha lmology 2004; 111: 75-84.
63. Gritz DC, et al.: The Antioxidants in Prevention of Cataracts Study: effects of antioxi-dant supplements on cataract progression in South India. Br J Ophthalmol 2006; 90:847-851.
64. Maraini G, et al.: A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities. Clinical trial of nutritional supplements and age-related cataract report No 3. Ophthalmology 2008; 115:599-607 e1.
65. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8. Arch Ophthalmol 2001; 119: 1417-1436.
66. Bjelakovic G, et al.: Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008;CD007176.
67. Lawlor DA, et al.: Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence? Lancet 2004; 363:1724-1727.
68. Fletcher AE: Controversy over 'contradict ion': shou ld r a ndomi z ed t ria l s a lways tr ump observational studies? Am J Ophthalmol 2009; 147:384-386.
69. Loktionov A: Common gene polymorphisms and nutrition: emerging links with patho-genesis of multifactorial chronic diseases (review). J Nutr Biochem 2003; 14:426-451.
70. Skibola CF, et al.: Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. PLoS One 2008; 3:e2 816.
71. Zerbib J, et al.: rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One 2009; 4:e7341.