Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  SanGiovanni, John Paul ^a   Arking, Dan E ^b   Iyengar, Sudha K ^c   Elashoff, Michael ^h   Clemons, Traci E ^d   Reed, George F ^a   Henning, Alice K ^d   Sivakumaran, Theru A ^c   Xu, Xuming ^e   DeWan, Andrew ^e   Agrón, Elvira ^a   Rochtchina, Elena ^f   Sue, Carolyn M ⁱ   Wang, Jie Jin ^f   Mitchell, Paul ^f   Hoh, Josephine ^e   Francis, Peter J ^g   Klein, Michael L ^g   Chew, Emily Y ^a   Chakravarti, Aravinda ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d EMMES CORPORATION   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF SYDNEY   (Australia)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^h CardioDx   (United States)

ⁱ UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; MALE; RETINA MACULA AGE RELATED DEGENERATION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; AGE DISTRIBUTION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MUTATION; RETINA MACULA DEGENERATION; SEX RATIO;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; MUTATION; SEX DISTRIBUTION;

EID: 65749108269     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005508     Document Type: Article

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