Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis

Acta Crystallographica Section D: Biological Crystallography

Volumn 66, Issue 9, 2010, Pages 1001-1011

  Morgunova, Ekaterina ^a   Illarionov, Boris ^b   Saller, Sabine ^b   Popov, Aleksander ^c   Sambaiah, Thota ^d   Bacher, Adelbert ^e   Cushman, Mark ^d   Fischer, Markus ^b   Ladenstein, Rudolf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HAMBURG   (Germany)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d PURDUE UNIVERSITY   (United States)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

anthrax; Bacillus anthracis; drug design; inhibition; lumazine synthase; riboflavin biosynthesis

Indexed keywords

6,7 DIMETHYL 8 RIBITYLLUMAZINE SYNTHASE; 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE; ENZYME INHIBITOR; MULTIENZYME COMPLEX;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS ANTHRACIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; THERMODYNAMICS; ANTAGONISTS AND INHIBITORS;

AMINO ACID SEQUENCE; BACILLUS ANTHRACIS; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BACILLUS ANTHRACIS;

EID: 77956554267     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444910029690     Document Type: Article

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