A new series of N-[2,4-dioxo-6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin- 5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications

Journal of Organic Chemistry

Volumn 73, Issue 7, 2008, Pages 2715-2724

  Zhang, Yanlei ^a   Illarionov, Boris ^b   Morgunova, Ekaterina ^d   Jin, Guangyi ^a   Bacher, Adelbert ^b   Fischer, Markus ^c   Ladenstein, Rudolf ^d   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CONFORMATIONS; CRYSTALLOGRAPHY; ENZYMES; METABOLISM; SYNTHESIS (CHEMICAL);

BIOCHEMICAL EVALUATION; HYPOTHETICAL INTERMEDIATES; RIBOFLAVIN SYNTHASE;

ORGANIC ACIDS;

ENZYME INHIBITOR; LUMAZINE; PYRIMIDINE DERIVATIVE; RIBOFLAVIN SYNTHASE; SCHIFF BASE; SYNTHETASE;

ARTICLE; BACILLUS SUBTILIS; CATALYSIS; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELIMINATION REACTION; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; SCHIZOSACCHAROMYCES POMBE; X RAY CRYSTALLOGRAPHY;

BACILLUS SUBTILIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; OXAMIC ACID; RIBOFLAVIN SYNTHASE; SCHIZOSACCHAROMYCES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41649106515     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo702631a     Document Type: Article

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