Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7- dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

Journal of Organic Chemistry

Volumn 70, Issue 20, 2005, Pages 8162-8170

  Cushman, Mark ^a   Jin, Guangyi ^a   Illarionov, Boris ^b   Fischer, Markus ^b   Ladenstein, Rudolf ^c   Bacher, Adelbert ^b  

^a PURDUE UNIVERSITY   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; COMPLEXATION; ENZYME KINETICS; ESCHERICHIA COLI; KETONES; MOLECULAR DYNAMICS; PHOSPHATES;

ELECTRON TRANSPORT; MOLECULAR MODELING; PHOSPHATE SIDE CHAINS; RIBITYLLUMAZINEDIONES;

AMINES;

4 (1,5,6,7 TETRAHYDRO 6,7 DIOXO 9 DEXTRO RIBITYLLUMAZIN 5 YL)PENTANE 1 PHOSPHATE; ALKYL GROUP; AMINE; BUFFER; CARBONYL DERIVATIVE; ENZYME INHIBITOR; LUMAZINE SYNTHASE; PHOSPHATE; PURINE DERIVATIVE; RIBOFLAVIN; RIBOFLAVIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME MECHANISM; ESCHERICHIA COLI; METABOLITE; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BACILLUS SUBTILIS; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; PTERIDINES; RIBOFLAVIN SYNTHASE;

EID: 25444530697     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo051332v     Document Type: Article

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