Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis

FEBS Journal

Volumn 273, Issue 20, 2006, Pages 4790-4804

  Morgunova, Ekaterina ^a   Illarionov, Boris ^b   Sambaiah, Thota ^c   Haase, Ilka ^b   Bacher, Adelbert ^b   Cushman, Mark ^c   Fischer, Markus ^b   Ladenstein, Rudolf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Crystal structure; Inhibition; Lumazine synthase; Mycobacterium tuberculosis

Indexed keywords

1,3,7 TRIHYDRO 9 DEXTRO RIBITYL 2,4,8 PURINETRIONE; 4 (6 CHLORO 2,4 DIOXO 1,2,3,4 TETRAHYDROPRIMIDIN 5 YL) BUTYLPHOSPHATE; 5 (1,3,7 TRIHYDRO 9 DEXTRO RIBITYL 2,4,8 PURINETRION 7 YL) 1,1 DIFLUORO PENTANE PHOSPHATE; 5 (1,3,7 TRIHYDRO 9 DEXTRO RIBITYL 2,4,8 PURINETRION 7 YL)HEXANE PHOSPHATE; 5 (1,3,7 TRIHYDRO 9 DEXTRO RIBITYL 2,4,8 PURINETRION 7 YL)PENTANEL PHOSPHATE; LUMAZINE; PHOSPHATE; PURINE DERIVATIVE; RIBITYLPURINETRIONE; RIBOFLAVIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; GENOMICS; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; THERMODYNAMICS;

BINDING SITES; BINDING, COMPETITIVE; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; RIBITOL; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; URACIL;

MYCOBACTERIUM TUBERCULOSIS;

EID: 33749389011     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05481.x     Document Type: Article

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